IndraLab

Statements

BCL6 inhibits BCL6. 10 / 16
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"Recently, it was reported that the acetylation of the proto-oncogene BCL6, which is a zinc finger transcription repressor, inactivates BCL6 [35]."
12878208
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"Together, these observations identified that loss of BCL6 directly relieves repression and potentiates PPARdelta mediated transactivation to restore fasting liver gene expression in Ppara -/-; Bcl6 LKO mice."
30983568
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"These data suggest that an interaction between Bcl6 and Prkd2 leads to Bcl6 phosphorylation, either directly by Prkd2 or via a Prkd2 kinase dependent event, thereby limiting Bcl6 access to the nucleus."
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"Moreover, ABC DLBCLs downmodulate BCL6 expression, likely as a result of their partial plasmacytic differentiation, thereby limiting the action of BCL6."
22224767
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"Third, overexpression of BCL6 in immortalized mouse mammary EpH4 cells blocked cellular differentiation and promoted proliferation, supporting a differentiation-suppressive role of BCL6 in mammary epithelial cells."
20124477
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"Together, these data support the hypothesis that T-bet is required to inhibit the modest amounts of Bcl-6 expressed in effector T H 1 cells to prevent Bcl-6 from dominantly repressing the expression of glycolysis pathway genes and that this activity is functionally important for promoting glycolysis in effector T H 1 cells."
25194422
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"Stat5 suppressed BCL6 expression in B-cell lymphomas, adipocytes and hepatocytes, but stimulated BCL6 in B lymphocytes and in insulin producing beta-cells during pregnancy."
20124477
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"Bcl-6 protein inhibition of the Bcl6 gene instead depends on CtBP xref ( xref )."
20084069
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"Acetylation of BCL6 inhibits the ability of BCL6 to recruit HDAC containing SMRT co-repressor complexes [XREF_BIBR]."
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"Accordingly, the expression of Bcl6 and T-bet, lineage defining transcription factors for Tfh and Th1 cells, respectively, revealed a mild but significant trend toward increased Tbet and decreased Bcl6 in response to strong stimulation (XREF_FIG)."
33684030
BCL6 bound to CDKN2A inhibits BCL6. 1 / 1
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"Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression.ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression."
15567177
BCL6 bound to Blimp-1 protein can inhibits BCL6. 1 / 1
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"Conversely, Blimp-1 protein can bind to Bcl6 and directly repress Bcl-6 production XREF_BIBR (XREF_FIG) and thereby induce plasma cell differentiation while inhibiting germinal center B cell differentiation XREF_BIBR, XREF_BIBR."
20084069