IndraLab

Statements

AR is modified
| 1 29
AR is palmitoylated. 10 / 30
| 1 29
sparser
"These data indicate that the mutation on β 2 AR palmitoylation site at C341 selectively reduces receptor association with PDE4 without globally disrupting association with AKAP and adenylate cyclase."
22912718
sparser
"We used two complimentary strategies to examine the functional implication of palmitoylation of β 2 AR in cardiomyocytes."
22912718
sparser
"Here we describe S -palmitoylation of the β 3 AR."
30541923
sparser
"Here, we demonstrate that in cardiomyocytes, palmitoylation of β 2 AR, the covalent acylation of cysteine residue 341, plays a critical role in shaping subcellular cAMP-PKA activities in cardiomyocytes via regulating β 2 AR association with arrestin/PDE4D. Replacing cysteine 341 on β 2 AR with alanine (C341A) leads to an impaired binding to β arrestin 2."
22912718
sparser
"A(1)AR palmitoylation is abolished by treatment with neutral hydroxylamine or by mutation of Cys-309 to Ala (C(309)-->A)."
10455026
sparser
"However, site-directed mutagenesis of this residue has not been performed for any AR subtype, and no role for putative AR palmitoylation has been described."
10722120
sparser
"Early studies suggest that the palmitoylation of β 2 AR reduces the receptor coupling to Gs proteins for activation of adenylate cyclase and PKA phosphorylation of receptor in Chinese hamster fibroblasts xref , the functional implication remains unclear."
22912718
sparser
"Disruption of Palmitoylation of β 2 AR Reduces Recruitment of Arrestin to the Phosphorylated Receptor Under Agonist Stimulation."
22912718
trips
"A(1)AR palmitoylation is abolished by treatment with neutral hydroxylamine or by mutation of Cys-309 to Ala (C(309)-->A)."
10455026
sparser
"Specifically, we like to examine whether palmitoylation of β 2 AR affects agonist-induced receptor trafficking and receptor association with other effectors like PDE4D isoforms in signaling complex."
22912718
PatS affects AR
| 1
PatS palmitoylates AR. 1 / 1
| 1
sparser
"Similarly, expression of the individual plasmids in C4-2 prostate cancer cells resulted in enhanced palmitoylation of endogenous AR only by the same PATs for palmitoylating ER and PR ( xref )."
22031296
ZDHHC21 affects AR
| 1
ZDHHC21 palmitoylates AR. 1 / 1
| 1
sparser
"These data suggest that ZDHHC21 does in fact increase steady state palmitoylation of α1D AR, as well as total expression of α1D AR."
26715683