The INDRA Database: Results
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phosphosite
cbn
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bel_lc
signor
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geneways
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sparser
reach
reading
FHIT is modified
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308
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"FHIT methylation was also observed in 13% cases in the adjacent control region."
sparser
"FHIT, mutated in four out of five liver metastases, is believed to be a tumor suppressor involved in purine metabolism and lower FHIT expression/promoter methylation is associated with poor outcome in non-small cell lung and breast cancer and metastasis in colon cancer xref , xref , xref ."
sparser
"The level of aberrant methylation of FHIT , obtained in our study on cfDNA (55.6%), was close to the results obtained in the study of Kvasha et al. in samples of RCC tumors (54.6%)."
sparser
"Moreover, patients with a higher FHIT methylation (>10%, n=22/40) showed a lower locoregional control rate than that of patients with lower methylation ( P = 0.038; Fig. xref )."
sparser
"Also, the frequency of promoter methylation of p16INK4a , MGMT , RASSF1A , MTHFR , and FHIT is higher in the NSCLC tumors of smokers relative to non-smokers [ xref , xref , xref – xref ]."
sparser
"Previous data related to cervical cancer showed that DAPK1, FHIT, MGMT, CDKN2A, CADM1 and MAL were frequently methylated genes in cervical carcinogenesis ( xref , xref )."
sparser
"In NSE, there was no promoter methylation of FHIT gene, while in LSCC the rate of it was 24.4% (10/41), and it was related to the tumor pathological grade and lymph node metastasis (P < 0.01)."
sparser
"Nicotine administration in human bronchial epithelial cells significantly upregulates several genes particularly associated with activation of mitogen activated protein kinase (MAPK).[ xref ] Nicotine increases methylation of the fragile histidine triad (FHIT) gene resulting in decreased FHIT and increased deoxyribonucleic acid (DNA) methyltransferase (DNMT) 3a expression.[ xref ] Notably, removal of nicotine restores normal methylation patterns and expression suggesting the effect of nicotine is reversible."
CXXC1 affects FHIT
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13
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"CpG island methylation of the FHIT and E-cadherin genes was detected in 30.46% and 39.74% of plasma samples, respectively, and in 53.33% and 60.0% of tissue samples, respectively."
sparser
"CpG island methylation of the FHIT and E-cadherin genes is present in plasma of cervical cancer patients."
sparser
"5 CpG island methylation of FHIT was investigated by methylation-specific polymerase chain reaction (PCR) assays."
sparser
"There were significant differences in HPV16 status (χ2=36.64, P<0.001), CpG island methylation of FHIT (χ2=71.31, P<0.001) and serum folate level (F=4.57, P=0.011) across the cervical histologic groups."
sparser
"5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas."
sparser
"The results analyzed by GMDR model showed that there were interactions among high MeCP2 protein expression, the CpG island methylation of FHIT and mRNA and protein expression in CINⅡ/Ⅲ group, and among high MeCP2 mRNA and protein expression, the CpG island methylation of FHIT and low mRNA and protein expression in SCC group."
sparser
"We investigated 5' CpG island methylation of the FHIT gene in 107 primary non-small cell lung cancer (NSCLC) samples and corresponding nonmalignant lung tissues, 39 primary breast carcinomas, as well as in 49 lung and 22 breast cancer cell lines by a methylation-specific PCR assay."
sparser
"Aberrant transcription of the FHIT gene has been observed in many solid tumors, suggesting that 5'-CpG island methylation of the FHIT gene is involved in tumor development."
sparser
"Of the 16 cervical carcinomas with 5'-CpG island methylation of the FHIT gene by PCR, 15 showed reduced FHIT protein expression."
RASSF1A genes affects FHIT
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3
reach
"This is the first study indicating a correlation between the promoter methylation of FHIT and RASSF1A genes and the clinical stage and histological grading of cervical carcinoma in Indian women."
reach
"As current evidence suggests the involvement of epigenetic modification of tumour suppressor genes in human cancer, we investigated the aberrant promoter methylation of FHIT and RASSF1A genes in human papillomavirus (HPV)-mediated cervical cancer in Indian women."
KRAS affects FHIT
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3
sparser
"Overall, advanced tumor stage (97%), metastatic disease (100%), moderately to poorly differentiated tumors (84%) and presence of lymphatic invasion (92%) were more frequently observed in tumors with mutated Kras (codon 12) and methylated RASSF1A, FHIT and MGMT genes."
sparser
"Overall, tumor stage 3, moderately differentiated tumors, presence of lymphatic invasion and absence of metastasis was more frequently observed in tumors with mutated Kras and/or methylated RASSF1A, FHIT and MGMT genes."
FHIT affects FHIT
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1
2
nicotine affects FHIT
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1
DNMT1 affects FHIT
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1