"FHIT methylation is associated with poor prognosis in ESCC."
"FHIT methylation was also observed in 13% cases in the adjacent control region."
"FHIT, mutated in four out of five liver metastases, is believed to be a tumor suppressor involved in purine metabolism and lower FHIT expression/promoter methylation is associated with poor outcome in non-small cell lung and breast cancer and metastasis in colon cancer xref , xref , xref ."
"The level of aberrant methylation of FHIT , obtained in our study on cfDNA (55.6%), was close to the results obtained in the study of Kvasha et al. in samples of RCC tumors (54.6%)."
"Moreover, patients with a higher FHIT methylation (>10%, n=22/40) showed a lower locoregional control rate than that of patients with lower methylation ( P = 0.038; Fig. xref )."
"Also, the frequency of promoter methylation of p16INK4a , MGMT , RASSF1A , MTHFR , and FHIT is higher in the NSCLC tumors of smokers relative to non-smokers [ xref , xref , xref – xref ]."
"Previous data related to cervical cancer showed that DAPK1, FHIT, MGMT, CDKN2A, CADM1 and MAL were frequently methylated genes in cervical carcinogenesis ( xref , xref )."
"In NSE, there was no promoter methylation of FHIT gene, while in LSCC the rate of it was 24.4% (10/41), and it was related to the tumor pathological grade and lymph node metastasis (P < 0.01)."
"Nicotine administration in human bronchial epithelial cells significantly upregulates several genes particularly associated with activation of mitogen activated protein kinase (MAPK).[ xref ] Nicotine increases methylation of the fragile histidine triad (FHIT) gene resulting in decreased FHIT and increased deoxyribonucleic acid (DNA) methyltransferase (DNMT) 3a expression.[ xref ] Notably, removal of nicotine restores normal methylation patterns and expression suggesting the effect of nicotine is reversible."
"Inverse correlation was found between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation."