IndraLab

Statements

FHIT is modified
| 433
FHIT is methylated. 10 / 433
| 433
sparser
"Overall, our study demonstrated that a very high percentage of ATL patient samples (74%) presented with FHIT methylation."
34092254
sparser
"FHIT methylation was also observed in 13% cases in the adjacent control region."
23573237
sparser
"In NSE, there was no promoter methylation of FHIT gene, while in LSCC the rate of it was 24.4% (10/41), and it was related to the tumor pathological grade and lymph node metastasis (P < 0.01)."
16013507
sparser
"DNA methylation of RARB, PGR, RASSF1, CDH1, FHIT, ESR1, C1QTNF6 , PTGS2, SOCS3 , MGMT , and LINE1 was analyzed by pyrosequencing and compared with results from the cell lines RT4, T24, HeLa, BEAS-2B, and HepG2."
23691160
sparser
"The tumor suppressor Fhit protein is defective or absent in many tumor cells due to methylation, mutation or deletion of the FHIT gene."
23993961
sparser
"To further explore the molecular mechanisms between altered TSGs promoter methylation and overexpression of DNMTs protein, we performed a tissue chromatin-immunoprecipitation polymerase chain reaction assay for lung tumors and showed that the methylated FHIT, p16(INK4a) and RARbeta promoters were bound by both DNMT protein and methyl-CpG-binding protein 2."
17140695
sparser
"While no FHIT gene promoter methylation was observed in the matched non-cancerous epithelium (NCE) specimens, 24.6% of DTC samples demonstrated methylation in the FHIT promoter region."
20606729
sparser
"Thus, Fhit is inactivated at an early stage in the development of ESCC ( xref ); FHIT gene promoter methylation has been linked to cigarette smoking ( xref , xref ), and ESCC may be associated with loss of the Fhit protein expression along with alcohol consumption ( xref , xref )."
28693209
sparser
"While methylation of DAP-Kinase and RAR B was equally distributed between tumors with or without schistosomal association, methylation of FHIT, RASSF1 A, E-cadherin, P16, and MGMT tended to be more common in the parasite-associated tumors."
25685453
sparser
"FHIT gene methylation may be one of the molecular events involved in the development and transformation of FMSCs into F6 tumor cells."
26137124
CXXC1 affects FHIT
| 14
CXXC1 methylates FHIT. 10 / 13
| 13
sparser
"Aberrant transcription of the FHIT gene has been observed in many solid tumors, suggesting that 5'-CpG island methylation of the FHIT gene is involved in tumor development."
14660280
sparser
"5'-CpG island methylation of the FHIT gene was detected in 40% (16/40) of the cervical cancer samples and in none of normal cervical epithelial specimens."
14660280
sparser
"CpG island methylation of FHIT was detected in 31.13% of the plasma samples, and in 53.33% of the tissue samples."
16963412
sparser
"CpG island methylation of the FHIT and E-cadherin genes was detected in 30.46% and 39.74% of plasma samples, respectively, and in 53.33% and 60.0% of tissue samples, respectively."
17009983
sparser
"5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas."
14660280
sparser
"We investigated 5' CpG island methylation of the FHIT gene in 107 primary non-small cell lung cancer (NSCLC) samples and corresponding nonmalignant lung tissues, 39 primary breast carcinomas, as well as in 49 lung and 22 breast cancer cell lines by a methylation-specific PCR assay."
11325823
sparser
"Of the 16 cervical carcinomas with 5'-CpG island methylation of the FHIT gene by PCR, 15 showed reduced FHIT protein expression."
14660280
sparser
"Methylation-specific PCR (MSP) was employed to examine CpG island methylation of the FHIT and E-cadherin genes in 151 pretreatment plasma samples and 30 tumor tissue samples from cervical cancer patients."
17009983
sparser
"CpG island methylation of the FHIT and E-cadherin genes is present in plasma of cervical cancer patients."
17009983
sparser
"5 CpG island methylation of FHIT was investigated by methylation-specific polymerase chain reaction (PCR) assays."
15219888
CXXC1 methylates FHIT. 1 / 1
| 1
sparser
"The proviral load did not correlate with the level of FHIT CpG methylation in these samples, nor age of the patient (Fig. xref c and data not shown)."
34092254
FHIT affects FHIT
| 3 1
FHIT methylates FHIT. 3 / 3
| 2 1
reach
"These results suggest that in ATL families, 1- FHIT methylation is higher in descendants with methylated FHIT (FHIT methylation = 100%) than in normal asymptomatic carriers (FHIT methylation = 5.62%), 2- children of ATL parents have strongly methylated FHIT regardless of whether they are asymptomatic carriers or have ATL, 3- FHIT methylation may be passed down from parents to children through additive or non-additive genetic effects."
34092254
reach
"Concordance analysis was performed between FHIT methylation and expression of Fhit as well as H4."
16863736
sparser
"Concordance analysis was performed between FHIT methylation and expression of Fhit as well as H4."
16863736
Modified FHIT leads to the methylation of FHIT. 1 / 1
| 1
reach
"Concordance rates of 75% and 81.7% were present between promoter methylation of FHIT and expression of Fhit (p = 0.035) and acetylated H4 (p = 0.02)."
16863736
RASSF1A genes affects FHIT
| 3
RASSF1A genes leads to the methylation of FHIT. 3 / 3
| 3
reach
"Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population."
18608185
reach
"This is the first study indicating a correlation between the promoter methylation of FHIT and RASSF1A genes and the clinical stage and histological grading of cervical carcinoma in Indian women."
18608185
reach
"As current evidence suggests the involvement of epigenetic modification of tumour suppressor genes in human cancer, we investigated the aberrant promoter methylation of FHIT and RASSF1A genes in human papillomavirus (HPV)-mediated cervical cancer in Indian women."
18608185
KRAS affects FHIT
| 3
KRAS methylates FHIT. 3 / 3
| 3
sparser
"Overall, advanced tumor stage (97%), metastatic disease (100%), moderately to poorly differentiated tumors (84%) and presence of lymphatic invasion (92%) were more frequently observed in tumors with mutated Kras (codon 12) and methylated RASSF1A, FHIT and MGMT genes."
23573237
sparser
"Overall, tumor stage 3, moderately differentiated tumors, presence of lymphatic invasion and absence of metastasis was more frequently observed in tumors with mutated Kras and/or methylated RASSF1A, FHIT and MGMT genes."
23573237
sparser
"Taken together, the data demonstrated that tumor stage 3, moderately differentiated tumors, presence of lymphatic invasion and absence of metastasis were more frequently observed in tumors with mutated Kras and methylated RASSF1A, FHIT and MGMT genes."
23573237
Nicotine affects FHIT
| 1
Nicotine leads to the methylation of FHIT. 1 / 1
| 1
reach
"In addition, aberrant methylation of FHIT can also be induced by nicotine XREF_BIBR, indicating its role in smoking related ESCC tumorigenesis."
22572016
Ethanol affects FHIT
| 1
Ethanol leads to the methylation of FHIT. 1 / 1
| 1
reach
"Smoking and alcohol ingestion may promote the methylation of FHIT and CDH13."
32474857
Bisphenol A affects FHIT
1 |
Bisphenol A methylates FHIT. 1 / 1
1 |
ctd
No evidence text available
28505145
ctd
No evidence text available
25214829
N-nitrosodiethylamine methylates FHIT. 1 / 1
1 |
ctd
No evidence text available
20970405
N-methyl-N-nitrosourea methylates FHIT. 1 / 1
1 |
ctd
No evidence text available
15937960
DNMT1 affects FHIT
| 1
DNMT1 methylates FHIT. 1 / 1
| 1
reach
"DNMT1 has been shown to be specifically over-expressed in NSCLC lung tumours compared to normal cells where DNMT1 over-expression resulted in increased methylation of the TSGs, FHIT, p16 INK4a and RARbeta 21."
29559689
BSG affects FHIT
| 1
BSG methylates FHIT. 1 / 1
| 1
sparser
"Next, we examined CD25−/+ fractions for FHIT gene methylation by BSG."
34092254
ctd
No evidence text available
15937960
3-methylcholanthrene methylates FHIT. 1 / 1
1 |
ctd
No evidence text available
20970405