IndraLab

Statements

ZUP1 affects DDX58
| 2
ZUP1 deubiquitinates DDX58. 2 / 2
| 2
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"USP3 is also a DUB that deubiquitinates K63-polyUb chain of both RIG-I and MDA5 and suppresses IFN-β activation [25]."
31208841
reach
"However, nairoviruses, like arterviruses, encode DUB enzymes that deubiquitinate RIG-I to prevent innate immune signaling activation (van Kasteren et al., 2012), suggesting that during nairovirus infection/replication a PAMP, likely a viral transcription product, is produced that can activate RIG-I."
25749629
ZUP1 affects proIL‐1β
| 1
ZUP1 deubiquitinates proIL‐1β. 1 / 1
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"In line with this work, Zhang et al.81 have shown that POH1, a DUB that forms part of the 19S subunit of the proteasome, interacts with and deubiquitinates proIL‐1β by decreasing the K63‐linked polyubiquitin chains, as well as decreasing the efficacy of proIL‐1β cleavage."
31679183
ZUP1 affects diphosphate(4-)
| 1
ZUP1 deubiquitinates diphosphate(4-). 1 / 1
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"DUB, deubiquitylating enzyme; NAE, NEDD8-activating enzyme; PPi, inorganic pyrophosphate; SAE, SUMO-activating enzyme.Figure 2: a | In the first step of UBL activation, E1s bind ATP and a cognate UBL and catalyse the formation of a UBL carboxy- terminal acyl adenylate."
21151032
ZUP1 affects TP53
| 1
ZUP1 deubiquitinates TP53. 1 / 1
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"We also developed a UbV targeting USP10, a second DUB that deubiquitinates p53, and showed that the UbV promoted export of p53 from the nucleus to the cytoplasm (Zhang, Sartori, et al., 2017)."
30851297
ZUP1 affects SUMO-activating enzyme.Figure 2
| 1
ZUP1 deubiquitinates SUMO-activating enzyme.Figure 2. 1 / 1
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"DUB, deubiquitylating enzyme; NAE, NEDD8-activating enzyme; PPi, inorganic pyrophosphate; SAE, SUMO-activating enzyme.Figure 2: a | In the first step of UBL activation, E1s bind ATP and a cognate UBL and catalyse the formation of a UBL carboxy- terminal acyl adenylate."
21151032
ZUP1 affects SUDS3
| 1
ZUP1 deubiquitinates SUDS3. 1 / 1
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"DUB-3 (also known as USP17) is a cytokine-inducible human DUB that was found to deubiquitinate SDS3 and block proliferation in HeLa cells [93]."
31208841
ZUP1 affects SAE
| 1
ZUP1 deubiquitinates SAE. 1 / 1
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"DUB, deubiquitylating enzyme; NAE, NEDD8-activating enzyme; PPi, inorganic pyrophosphate; SAE, SUMO-activating enzyme.Figure 2: a | In the first step of UBL activation, E1s bind ATP and a cognate UBL and catalyse the formation of a UBL carboxy- terminal acyl adenylate."
21151032
ZUP1 affects NLRP7
| 1
ZUP1 deubiquitinates NLRP7. 1 / 1
| 1
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"Bednash et al.75 showed that the DUB STAMPBP (or AMSH) deubiquitinates NLRP7 rescuing this receptor from progressing to lysosome degradation and making it available for the formation of an active inflammasome.NLRC4 inflammasome activation can also be controlled by ubiquitination, although very little is known about how this occurs."
31679183
ZUP1 affects NFKBIA
| 1
ZUP1 leads to the deubiquitination of NFKBIA. 1 / 1
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"The DUB-like SseL factor produced by S. Typhimurium inhibits IkBa ubiquitination in response to the TNF-a cytokine, suggesting that SseL acts directly by removing the K48-linked chains of IkBa (Le Negrate et al., 2008) ."
21111231
ZUP1 affects NEDD8
| 1
ZUP1 deubiquitinates NEDD8. 1 / 1
| 1
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"DUB, deubiquitylating enzyme; NAE, NEDD8-activating enzyme; PPi, inorganic pyrophosphate; SAE, SUMO-activating enzyme.Figure 2: a | In the first step of UBL activation, E1s bind ATP and a cognate UBL and catalyse the formation of a UBL carboxy- terminal acyl adenylate."
21151032
ZUP1 affects NAE
| 1
ZUP1 deubiquitinates NAE. 1 / 1
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"DUB, deubiquitylating enzyme; NAE, NEDD8-activating enzyme; PPi, inorganic pyrophosphate; SAE, SUMO-activating enzyme.Figure 2: a | In the first step of UBL activation, E1s bind ATP and a cognate UBL and catalyse the formation of a UBL carboxy- terminal acyl adenylate."
21151032
ZUP1 affects IKB
| 1
ZUP1 leads to the deubiquitination of IKB. 1 / 1
| 1
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"The DUB-like SseL factor produced by S. Typhimurium inhibits IkBα ubiquitination in response to the TNF-α cytokine, suggesting that SseL acts directly by removing the K48-linked chains of IkBα (Le Negrate et al., 2008)."
21111231
ZUP1 affects IFIH1
| 1
ZUP1 deubiquitinates IFIH1. 1 / 1
| 1
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"USP3 is also a DUB that deubiquitinates K63-polyUb chain of both RIG-I and MDA5 and suppresses IFN-β activation [25]."
31208841
ZUP1 affects FOXO4
| 1
ZUP1 deubiquitinates FOXO4. 1 / 1
| 1
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"Notably, USP7 has been identified as the DUB that deubiquitylates FOXO4 and modulates its transcriptional activity in response to oxidative stress [98], making USP7 a prime controller of oxidative stress responses that are frequent hallmarks of tumours and are often associated with the DDR defects [99]."
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