IndraLab

Statements

USP6 affects JAK1
| 1 4
USP6 deubiquitinates JAK1. 4 / 4
| 1 3
reach
"We previously showed that ubiquitin specific protease 6 (USP6) directly deubiquitinates and stabilizes Jak1, thereby inducing an IFN signature in ES cells."
33558334
reach
"To test whether USP6 can induce de-ubiquitination of Jak1 in vivo, HeLa cells were co-transfected with FLAG-Jak1, Myc-Ub, and HA-USP6 alleles."
27440725
reach
"We found that USP6 directly deubiquitinated Jak1, leading to its stabilization and activation of STAT3."
27440725
trips
"We found that USP6 directly deubiquitinated Jak1, leading to its stabilization and activation of STAT3."
27440725
Modified USP6 leads to the deubiquitination of JAK1. 1 / 1
| 1
reach
"Co-expression of USP6, but not USP6 (short), completely abolished ubiquitination of Jak1 in vivo (XREF_FIG)."
27440725
USP6 affects MMP9
1 |
USP6 deubiquitinates MMP9. 1 / 1
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USP6 affects JUN
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USP6 deubiquitinates JUN. 1 / 1
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ubibrowser
"Based on our data, USP6 is an enzyme that deubiquitinates c-Jun and regulates its downstream cellular functions."
29061731
USP6 affects GRIN1
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USP6 deubiquitinates GRIN1. 1 / 1
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ubibrowser
"We also found that USP6 binds to and deubiquitinates NMDARs, thereby enhancing NMDAR stability."
31841517