IndraLab

Statements


USP42 affects TP53
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USP42 deubiquitinates TP53. 7 / 7
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"It has been reported that USP42 interacts with and deubiquitinates p53."

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"In the initial phases of a stress response, USP42 deubiquitinates p53 by forming a direct complex with p53."

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"During the early phase of response to a stress signal, USP42 preferentially makes up a complex with and deubiquitinates p53, leading to the rapid activation of p53 for cell cycle arrest and p53-dependent transcription [55]."
| PMC

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"P53 can be directly deubiquitinated by Usp42 which reverses its ubiquitination by MDM2 [XREF_BIBR]."

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"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."

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"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."
USP42 affects Histone_H2B
| 2
USP42 deubiquitinates Histone_H2B. 2 / 2
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"Interestingly, USP42 was also proposed to regulate transcription by deubiquitylating histone H2B [56]."

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"Indeed, in vitro analysis showed that USP42 is able to efficiently deubiquitylate histone H2B (XREF_FIG, E and F)."
USP42 affects histone H2B .
| 1
USP42 deubiquitinates histone H2B .. 1 / 1
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"USP42 was suggested to enhance transcription by deubiquitylating histone H2B ."
USP42 affects MMP9
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USP42 deubiquitinates MMP9. 1 / 1
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USP42 affects H2BC10
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USP42 deubiquitinates H2BC10. 1 / 1
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"Depletion of USP42 increased H2B ubiquitylation at a model promoter and decreased both basal and induced transcription from a number of promoters."