IndraLab

Statements


USP26 affects AR
1 | 1 4
USP26 deubiquitinates AR. 6 / 6
1 | 1 4

reach
"Taken together, the effects of AR deubiquitinated by USP26 could modulate sperm maturation and spermatogenesis through the androgen receptor signaling pathway."

reach
"Elevated cellular ROS levels might then inhibit USP26 activity to increase the ubiquitination of androgen receptor (AR) and AR splice variant 7 (ARv7) and their ubiquitin and proteasome dependent degradation, which contributed to the increase of Enz sensitivity."

trips
"USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway."

"Our data suggest that USP26 assembles with AR and other cofactors in subnuclear foci, and serves to counteract hormone-induced AR ubiquitination, thereby contributing to the regulation of AR transcriptional activity."

reach
"USP26 can deubiquitylate AR in the presence of androgen, while USP10 and 2A-DUB both regulate AR transcriptional activity but do not alter protein stability."

reach
"USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway."
USP26 affects MDM2
1 | 1 2
USP26 deubiquitinates MDM2. 4 / 4
1 | 1 2

reach
"USP26 also deubiquitinates and stabilizes Mdm2 [70] thus underlining the complex regulation of AR transcriptional activity."

trips
"USP26 deubiquitinates Mdm2 and stabilizes it."

reach
"USP26 deubiquitinates Mdm2 and stabilizes it."
USP26 affects SMAD7
1 | 2
USP26 deubiquitinates SMAD7. 3 / 3
1 | 2

"USP26 regulates TGF-b signaling by deubiquitinating and stabilizing SMAD7."

reach
"USP26 deubiquitinates SMAD7."

reach
"Examples include ubiquitin specific protease 10 (USP10), which can act on SMAD4 to make it deubiquitinated and stable, further promoting TGF-beta signaling [XREF_BIBR], and USP26, which promotes SMAD7 deubiquitination, thereby amplifying the inhibitory effect of SMAD7 and strengthening the inhibition of the TGF-beta signaling pathway [XREF_BIBR]."
| PMC
USP26 affects PRC1
1 | 1
USP26 deubiquitinates PRC1. 2 / 2
1 | 1

reach
"In some cancer types, PRC1 can be deubiquitinated by USP7, USP11 and USP26 [XREF_BIBR, XREF_BIBR]."
USP26 affects H2AC17
1 |
USP26 deubiquitinates H2AC17. 1 / 1
1 |