IndraLab

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USP26 deubiquitinates AR. 6 / 6
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"USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway."
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"USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway."
33064378
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"Taken together, the effects of AR deubiquitinated by USP26 could modulate sperm maturation and spermatogenesis through the androgen receptor signaling pathway."
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"USP26 can deubiquitylate AR in the presence of androgen, while USP10 and 2A-DUB both regulate AR transcriptional activity but do not alter protein stability."
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"Elevated cellular ROS levels might then inhibit USP26 activity to increase the ubiquitination of androgen receptor (AR) and AR splice variant 7 (ARv7) and their ubiquitin and proteasome dependent degradation, which contributed to the increase of Enz sensitivity."
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"Our data suggest that <span class="match term0">USP26</span> assembles with <span class="match term1">AR</span> and other cofactors in subnuclear foci, and serves to counteract hormone-induced <span class="match term1">AR</span> ubiquitination, thereby contributing to the regulation of <span class="match term1">AR</span> transcriptional activity."
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