IndraLab

Statements

COPS6 affects MDM2
| 3
COPS6 leads to the deubiquitination of MDM2 on K364. 2 / 2
| 2
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"Mechanism studies indicated that CSN6 prevented MDM2 autoubiquitination at lysine 364, resulting in stabilization of MDM2 and degradation of p53."
24286178
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"Previous studies have demonstrated that CSN6 prevents MDM2 autoubiquitination at lysine 364, which results in the stabilization of MDM2 and the degradation of p53."
27748879
Modified COPS6 leads to the deubiquitination of MDM2 on K364. 1 / 1
| 1
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"Expression of CSN6 appeared to prevent MDM2 autoubiquitination at lysine 364, resulting in stabilization of MDM2 and degradation of p53."
21317535
COPS6 affects TRIM21
| 2
COPS6 leads to the deubiquitination of TRIM21. 2 / 2
| 2
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"Moreover, MLN4924 treatment abrogated TRIM21 ubiquitination promoted by CSN6."
32225170
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"45 Interestingly, CSN6 is able to decrease the steady-state expression of TRIM21 by enhancing TRIM21 ubiquitination, thereby promoting cancer stemness."
32225170
COPS6 affects Snail1
| 2
COPS6 leads to the deubiquitination of Snail1. 2 / 2
| 2
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"CSN6 probably functions to inhibit Snail1 ubiquitination and then switches the E3 ligase target from Snail1 itself to other proteins."
33162808
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"CSN6 induces EMT and enhances metastasis of breast cancer cells by reducing Snail1 ubiquitination."
33162808
COPS6 affects POU2F1
| 2
COPS6 leads to the deubiquitination of POU2F1. 2 / 2
| 2
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"Moreover, overexpression of CSN6 reduced OCT1 ubiquitination, while ectopic expression of TRIM21 reversed this effect."
32225170
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"Simultaneously, knockdown of CSN6 increased OCT1 ubiquitination, while knockdown of TRIM21 reversed this impact."
32225170
COPS6 affects CDK9
| 2
COPS6 leads to the deubiquitination of CDK9. 2 / 2
| 2
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"In addition, to investigate whether CSN6 controls the ubiquitination and degradation of the E3 ligase UBR5 to stabilize CDK9, in vivo ubiquitination assays were performed and found that CSN6 increased UBR5 ubiquitination levels and decreased CDK9 ubiquitination levels in melanoma cells and 293FT cells."
33483464
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"CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5 mediated ubiquitination and degradation of CDK9."
33483464
COPS6 affects MYC
| 1
Modified COPS6 leads to the deubiquitination of MYC. 1 / 1
| 1
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"Because Myc is degraded through the ubiquitin pathway 38, we examined whether ubiquitination is involved and found that CSN6 overexpression inhibited Myc ubiquitination while shRNA-CSN6 increased Myc ubiquitination (XREF_FIG)."
25395170
COPS6 affects JUN
| 1
Modified COPS6 leads to the deubiquitination of JUN. 1 / 1
| 1
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"In addition, overexpression of CSN6 could also reduce the ubiquitination of the proto-oncoprotein c-Jun mediated by the E3 ubiquitin ligase MEKK1 and promote cell proliferation in the human embryonic kidney cell lines XREF_BIBR."
33162808
COPS6 affects EGFR
| 1
COPS6 leads to the deubiquitination of mutated EGFR. 1 / 1
| 1
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"Reduction of mutant EGFR ubiquitination by CSN6 causes steadily elevated levels of EGFR, leading to proliferation, migration, invasion, and tumorigenesis 35."
32943616
COPS6 affects E6
| 1
COPS6 leads to the deubiquitination of E6. 1 / 1
| 1
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"Meanwhile, CSN6 could bind to the E6 oncoprotein of human papillomavirus (HPV) and inhibit the polyubiquitination of E6 to reduce its degradation, thereby regulating the activity of p53 in cell proliferation and apoptosis to affect the development of cervical cancer XREF_BIBR."
33162808
COPS6 affects DDX5
| 1
COPS6 leads to the deubiquitination of DDX5. 1 / 1
| 1
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"CSN6 inhibited β-Trcp-mediated DDX5 polyubiquitination and degradation, which in turn promoted DDX5-mediated PHGDH mRNA stabilization, leading to metabolic reprogramming and CRC progression."
36512632