IndraLab

Statements

"The results showed that MP470 increased the ubiquitination level of RUNX1, leading to a decrease in RUNX1 protein level, which may be due to its inhibition of the interaction between RUNX1 and USP31."

38886545

➶

reach

"MP470 was chosen as an inhibitor of the interaction between USP31 and RUNX1, results suggested that the USP31 protein acts through deubiquitination to affect the RUNX1 protein."

38886545

➶

biogrid

No evidence text available

38886545

➶

biogrid

No evidence text available

38886545

➶

reach

"To verify whether the two proteins interact with each other, through co-IP, and the results show that RUNX1 can bind to USP31 (Fig. 5D)."

38886545

➶

reach

"Therefore, we selected MP470 for interfering with the interaction between RUNX1 and USP31."

38886545

➶

reach

"Taken together, these data further supported that the binding of USP31 to RUNX1, and showed that USP31 could mediate the deubiquitination of RUNX1 and regulate its transcriptional function."

38886545

➶

reach

"In addition, there may be an interaction between the two proteins, RUNX1 and USP31, with modification of deubiquitination leading to upregulation of RUNX1 level expression (Fig. 7)."

38886545

USP31 deubiquitinates RUNX1.

| 2

USP31 leads to the deubiquitination of RUNX1. 2 / 2

| 2

➶

reach

"Taken together, these data further supported that the binding of USP31 to RUNX1, and showed that USP31 could mediate the deubiquitination of RUNX1 and regulate its transcriptional function."

38886545

➶

reach

"USP31 mediates the deubiquitination of RUNX1 and regulates its transcriptional function."

38886545

USP31 activates RUNX1.

| 1

USP31 activates RUNX1. 1 / 1

| 1

➶

reach

"Furthermore, we demonstrate that CDC20 and MCM2 may be target genes of RUNX1, and that RUNX1 may be physically linked to the deubiquitinating enzyme USP31, which mediates the upregulation of RUNX1 protein to promote transcriptional function."

38886545

USP31 affects NFkappaB

| 1 7

USP31 inhibits NFkappaB.

| 1 5

USP31 inhibits NFkappaB. 6 / 6

| 1 5

➶

reach

"USP31 and USP7 also inhibit NF-kappaB signaling by deubiquitinating K63 linked polyubiquitin chains [XREF_BIBR, XREF_BIBR]."

33498196

➶

reach

"In this study, repression of USP31 induced more NF-kB activity, promoting proliferation and reducing the differentiation capacity."

36551696

➶

reach

"USP31 overexpression inhibited NF-kappaB activation mediated by TNFalpha and two members of the TNFR family, CD40 and LMP1, whereas it had no effect on the basal NF-kappaB activity."

16214042

➶

reach

"USP31 also inhibited NF-kappaB activation mediated by two TRAF proteins (TRAF2 and TRAF6), as well as by the IKKbeta kinase."

16214042

➶

reach

"YAP1 Mediated Suppression of USP31 Enhances NFkappaB Activity to Promote Sarcomagenesis."

29490948

➶

eidos

"USP31 and USP7 also inhibit NF-kappaB signaling by deubiquitinating K63-linked polyubiquitin chains [ 38,39 ] ."

33498196

USP31 activates NFkappaB.

| 2

USP31 activates NFkappaB. 2 / 2

| 2

➶

reach

"These results reinforce the notion that USP31 has a specific role in NF-kappaB activation induced by TRAFs and members of the TNFR family.The nuclear localization of USP31 and its implication in NF-ka[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16214042

➶

reach

"The inhibition of NF-kappaB activation by USP31 was not due to a reduction of effector protein expression, since Western blot analysis revealed that the levels of all effector proteins were unaffected[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16214042

RUNX1 affects USP31

2 | 6

RUNX1 binds USP31. 8 / 8

2 | 6

➶

reach

38886545

➶

reach

"MP470 was chosen as an inhibitor of the interaction between USP31 and RUNX1, results suggested that the USP31 protein acts through deubiquitination to affect the RUNX1 protein."

38886545

➶

biogrid

No evidence text available

38886545

➶

biogrid

No evidence text available

38886545

➶

reach

"To verify whether the two proteins interact with each other, through co-IP, and the results show that RUNX1 can bind to USP31 (Fig. 5D)."

38886545

➶

reach

"Therefore, we selected MP470 for interfering with the interaction between RUNX1 and USP31."

38886545

➶

reach

"Taken together, these data further supported that the binding of USP31 to RUNX1, and showed that USP31 could mediate the deubiquitination of RUNX1 and regulate its transcriptional function."

38886545

➶

reach

"In addition, there may be an interaction between the two proteins, RUNX1 and USP31, with modification of deubiquitination leading to upregulation of RUNX1 level expression (Fig. 7)."

38886545

USP31 is modified

5 | 1

USP31 is phosphorylated.

4 |

USP31 is phosphorylated on T1056. 1 / 1

1 |

➶

hprd

No evidence text available

17287340

USP31 is phosphorylated on S1241. 1 / 1

1 |

➶

hprd

No evidence text available

19413330

USP31 is phosphorylated on S1052. 1 / 1

1 |

➶

hprd

No evidence text available

17287340

USP31 is phosphorylated on T5. 1 / 1

1 |

➶

hprd

No evidence text available

19413330

USP31 is acetylated.

1 | 1

USP31 is acetylated on K1264. 1 / 1

| 1

➶

trips

"USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth."

34184746

USP31 is acetylated on K1236. 1 / 1

1 |

➶

hprd

No evidence text available

19413330

USP31 affects TRAF2

1 1 | 1 1

USP31 inhibits TRAF2.

| 1

USP31 inhibits TRAF2. 1 / 2

| 1

➶

eidos

"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."

24260525

USP31 binds TRAF2.

1 | 1

USP31 binds TRAF2. 2 / 2

1 | 1

➶

biogrid

No evidence text available

16214042

➶

reach

"To confirm that the interaction between TRAF2 and USP31 in mammalian cells occurs via the RING finger domain of TRAF2, as indicated by our two-hybrid results, a mutated form of TRAF2 with a RING finge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16214042

USP31 decreases the amount of TRAF2.

1 |

USP31 decreases the amount of TRAF2. 1 / 1

1 |

➶

bel

"Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta-mediated NF-kappaB activation, but did not inhibit Smad-mediated transcription activation. In addition, both USP31 isoforms interact with p65/RelA."

16214042

RELA affects USP31

1 | 3

RELA binds USP31.

1 | 1

USP31 binds RELA. 2 / 3

1 | 1

➶

biogrid

No evidence text available

16214042

➶

reach

"A candidate target of USP31 could be p65 and RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."

16214042

RELA activates USP31.

| 2

RELA activates USP31. 2 / 2

| 2

➶

reach

"P65 and RelA is a possible target of USP31, since it is a major component of NF-kappaB and it is ubiquitinated and degraded by the proteasome in the nucleus [12]."

16214042

➶

reach

"p65 and RelA is a possible target of USP31, since it is a major component of NF-kappaB and it is ubiquitinated and degraded by the proteasome in the nucleus [12]."

16214042

USP31 affects autophagy

| 4

USP31 activates autophagy. 4 / 4

| 4

➶

reach

"Immunofluorescence analysis illustrated that USP31 knockdown blocked the occurrence of LUSC autophagy."

38204265

➶

reach

"In summary, this investigation proved that USP31 promoted LUSC cell growth and autophagy, at least in part by stabilizing E2F1 expression, which provided a potential therapeutic gene for the treatment of LUSC."

38204265

➶

reach

"Deubiquitylase USP31 Induces Autophagy and Promotes the Progression in Lung Squamous Cell Carcinoma Cells by Stabilizing E2F1 Expression."

38204265

➶

reach

"However, whether USP31 modulates autophagy in LUSC remains unclear."

38204265

USP31 affects apoptotic process

| 4

USP31 activates apoptotic process.

| 3

USP31 activates apoptotic process. 3 / 3

| 3

➶

reach

"We also observed that mutated USP31 could promote apoptosis but not cell cycle by flow cytometer analysis."

34184746

➶

reach

"Notably, acetylation of USP31 at Lys1264 fosters cervical cancer cell survival and resistance to cisplatin-induced apoptosis."

38702734

➶

reach

"The results showed that mutation in USP31 could promote apoptosis but inhibits cell cycle progression [114] ."

34606852

USP31 inhibits apoptotic process.

| 1

USP31 inhibits apoptotic process. 1 / 1

| 1

➶

reach

"However, the apoptosis induced by DDP could be resisted by USP31 acetylation in CC [44]."

35983979

USP31 affects RELA

1 | 2

USP31 binds RELA.

1 | 1

USP31 binds RELA. 2 / 3

1 | 1

➶

biogrid

No evidence text available

16214042

➶

reach

"A candidate target of USP31 could be p65 and RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."

16214042

USP31 increases the amount of RELA.

| 1

USP31 acetylated on K1264 increases the amount of RELA. 1 / 1

| 1

➶

reach

"Similarly, Hou et al. unrevealed the potential link between acetylation and cell cycle through the involvement of ubiquitin-specific protease 31 (USP31), where acetylation of USP31 at K1264 decreases [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

34606852

ELAVL1 affects USP31

2 | 2

ELAVL1 binds USP31.

2 |

USP31 binds ELAVL1. 2 / 2

2 |

➶

biogrid

No evidence text available

39028686

➶

biogrid

No evidence text available

39028686

ELAVL1 activates USP31.

| 2

ELAVL1 activates USP31. 2 / 2

| 2

➶

reach

"CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages."

39028686

➶

reach

"Our findings provide solid evidence macrophagic-expressed circARCN1 plays a role in atherosclerosis development by regulating HuR-mediated USP31 mRNA stability and NF-κB activation, suggesting that circARCN1 may serve as a factor for atherosclerotic lesion formation."

39028686

Sodium arsenite affects USP31

3 |

Sodium arsenite decreases the amount of USP31.

2 |

Sodium arsenite decreases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

37682722

➶

ctd

No evidence text available

38568856

Sodium arsenite increases the amount of USP31.

1 |

Sodium arsenite increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

21297353

Bisphenol A affects USP31

3 |

Bisphenol A decreases the amount of USP31.

2 |

Bisphenol A decreases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

25181051

➶

ctd

No evidence text available

33243503

Bisphenol A increases the amount of USP31.

1 |

Bisphenol A increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

33296240

Aflatoxin B1 affects USP31

3 |

Aflatoxin B1 increases the amount of USP31.

2 |

Aflatoxin B1 increases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

19770486

➶

ctd

No evidence text available

27153756

Aflatoxin B1 decreases the amount of USP31.

1 |

Aflatoxin B1 decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

33354967

YAP1 affects USP31

| 3

YAP1 inhibits USP31.

| 2

YAP1 inhibits USP31. 2 / 2

| 2

➶

reach

"It is worth noting that YAP1 was shown to inhibit the negative regulatory factor of NF-κB USP31 and induce excessive tumor cell proliferation."

34659495

➶

reach

"YAP1 promoted sarcomagenesis by inhibiting expression of ubiquitin specific peptidase 31 (USP31), a newly identified upstream negative regulator of NFkappaB signaling."

29490948

YAP1 decreases the amount of USP31.

| 1

YAP1 decreases the amount of USP31. 1 / 1

| 1

➶

reach

"In soft tissue sarcomas, YAP was found to suppress the expression of ubiquitin-specific peptidase 31 (USP31), a negative regulator of NF-κB signaling, leading to the promotion of sarcomagenesis (41)."

35210364

USP31 affects PKD1L3

| 3

PKD1L3 binds USP31. 3 / 3

| 3

➶

reach

"Therefore, we hypothesized that Hsp90 would be involved in CSFV-IRES and FMDV-IRES activities in association with eIF3c, and that both these proteins would interact with common host factors PKD1L3 and USP31.We first fixed anti-PKD1L3 or USP31 antibodies (Fig. 5A) and anti-Myc or anti-HA antibodies (Fig. 5B) to Magnosphere™ gel to examine the interaction between PKD1L3 and USP31."

40188851

➶

reach

"*Characterization of interaction of PKD1L3 and USP31 with eIF3c and Hsp90beta."

40188851

➶

reach

"It also provides the first report on PKD1L3 and USP31 interactions with eIF3c and Hsp90β, which may also play a role in such viral IRES-mediated translation."

40188851

USP31 affects GPX4

2 | 1

GPX4 binds USP31. 3 / 3

2 | 1

➶

biogrid

No evidence text available

37011699

➶

biogrid

No evidence text available

40382845

➶

reach

"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."

37011699

USP31 affects CD40

1 | 1

USP31 inhibits CD40.

| 1

USP31 inhibits CD40. 1 / 2

| 1

➶

eidos

24260525

USP31 decreases the amount of CD40.

1 |

USP31 decreases the amount of CD40. 1 / 1

1 |

➶

bel

16214042

PKD1L3 affects USP31

| 3

PKD1L3 binds USP31. 3 / 3

| 3

➶

reach

40188851

➶

reach

"*Characterization of interaction of PKD1L3 and USP31 with eIF3c and Hsp90beta."

40188851

➶

reach

"It also provides the first report on PKD1L3 and USP31 interactions with eIF3c and Hsp90β, which may also play a role in such viral IRES-mediated translation."

40188851

GPX4 affects USP31

2 | 1

GPX4 binds USP31. 3 / 3

2 | 1

➶

biogrid

No evidence text available

37011699

➶

biogrid

No evidence text available

40382845

➶

reach

"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."

37011699

Thioacetamide affects USP31

2 |

Thioacetamide increases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

34492290

➶

ctd

No evidence text available

23411599

Silver(0) affects USP31

2 |

Silver(0) decreases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

27131904

➶

ctd

No evidence text available

26014281

Paracetamol affects USP31

2 |

Paracetamol increases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

29067470

➶

ctd

No evidence text available

33387578

Manganese(II) chloride affects USP31

2 |

Manganese(II) chloride increases the amount of USP31.

1 |

Manganese(II) chloride increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Manganese(II) chloride decreases the amount of USP31.

1 |

Manganese(II) chloride decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Manganese atom affects USP31

2 |

Manganese atom increases the amount of USP31.

1 |

Manganese atom increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Manganese atom decreases the amount of USP31.

1 |

Manganese atom decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Folic acid affects USP31

2 |

Folic acid decreases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

25629700

➶

ctd

No evidence text available

21867686

Benzo[a]pyrene affects USP31

2 |

Benzo[a]pyrene increases the amount of USP31.

1 |

Benzo[a]pyrene increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

34015484

Benzo[a]pyrene decreases the amount of USP31.

1 |

Benzo[a]pyrene decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

19770486

USP31 affects inflammatory response

| 2

USP31 activates inflammatory response. 2 / 2

| 2

➶

reach

"USP31 promotes the inflammatory response of human lung organoids to lipopolysaccharide treatment."

39194225

➶

reach

"Notably, USP31 emerged as the most significantly upregulated USP, and the knockdown of USP31 markedly attenuated the inflammatory response of HLOs to LPS treatment."

39194225

USP31 affects Wnt/β-catenin

| 2

USP31 deubiquitinates Wnt/β-catenin.

| 1

USP31 leads to the deubiquitination of Wnt/β-catenin. 1 / 1

| 1

➶

reach

"Therefore, USP31 reduces the level of ubiquitination of the Wnt/β-catenin pathway by binding to β-catenin, thereby activating glycolysis, which ultimately promotes GC proliferation and aggressive metastasis."

38715330

USP31 activates Wnt/β-catenin.

| 1

USP31 activates Wnt/β-catenin. 1 / 1

| 1

➶

reach

"USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration."

38715330

USP31 affects TRAF6

| 1

USP31 inhibits TRAF6. 1 / 2

| 1

➶

eidos

24260525

USP31 affects TNF

1 | 1

USP31 inhibits TNF.

| 1

USP31 inhibits TNF. 1 / 1

| 1

➶

eidos

24260525

USP31 decreases the amount of TNF.

1 |

USP31 decreases the amount of TNF. 1 / 1

1 |

➶

bel

16214042

USP31 affects HSP90

| 2

USP31 leads to the deubiquitination of HSP90. 2 / 2

| 2

➶

reach

"Interestingly, a recent study indicated that USP31 reduces Hsp90β ubiquitination, resulting in increased Hsp90β levels in a nonalcoholic steatohepatitis (NASH) mouse model (Zhang et al., 2024)."

40188851

➶

reach

"A recent study indicated that USP31 reduces Hsp90β ubiquitination, resulting in increased Hsp90β levels in a nonalcoholic steatohepatitis (NASH) mouse model (Zhang et al., 2024)."

40188851

USP31 affects ELAVL1

2 |

USP31 binds ELAVL1. 2 / 2

2 |

➶

biogrid

No evidence text available

39028686

➶

biogrid

No evidence text available

39028686

TRAF2 affects USP31

1 | 1

USP31 binds TRAF2. 2 / 2

1 | 1

➶

biogrid

No evidence text available

16214042

➶

reach

16214042

SREBF1 affects USP31

2 |

SREBF1 decreases the amount of USP31. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

SHH affects USP31

| 2

SHH increases the amount of USP31. 2 / 2

| 2

➶

reach

"In hepatocytes, Shh increased Usp31 gene expression in a time- and dose-dependent manner, which was suppressed by Shh inhibition (Fig. 4h, and Supplementary Fig. 8c)."

38342927

➶

reach

"The activation of the SHH pathway promoted Hsp90β stability by increasing the expression of Usp31 via Bmal1 (Figs."

38342927

E2F1 affects USP31

| 2

E2F1 activates USP31. 2 / 2

| 2

➶

reach

"Furthermore, overexpressed E2F1 effectively eliminated the effect of USP31 knockdown on LUSC cell proliferation and autophagy."

38204265

➶

reach

38204265

2,3,7,8-tetrachlorodibenzodioxine affects USP31

2 |

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

33387578

➶

ctd

No evidence text available

32109520

17alpha-ethynylestradiol affects USP31

2 |

17alpha-ethynylestradiol increases the amount of USP31. 2 / 2

2 |

➶

ctd

No evidence text available

29097150

➶

ctd

No evidence text available

34015484

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone affects USP31

2 |

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone increases the amount of USP31.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone decreases the amount of USP31.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine affects USP31

2 |

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine increases the amount of USP31.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine decreases the amount of USP31.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

Zoledronic acid affects USP31

1 |

Zoledronic acid increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

20977926

Vinclozolin affects USP31

1 |

Vinclozolin decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

23034163

Valproic acid affects USP31

1 |

Valproic acid increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

23179753

Tris(1,3-dichloro-2-propyl)phosphate affects USP31

1 |

Tris(1,3-dichloro-2-propyl)phosphate increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

26179874

Tetrachloromethane affects USP31

1 |

Tetrachloromethane increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Sunitinib affects USP31

1 |

Sunitinib increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Schizandrin B affects USP31

1 |

Schizandrin B decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Rotenone affects USP31

1 |

Rotenone decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

39786591

Mono(2-ethylhexyl) phthalate affects USP31

1 |

Mono(2-ethylhexyl) phthalate increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

38685446

Leflunomide affects USP31

1 |

Leflunomide increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

28988120

Lead diacetate affects USP31

1 |

Lead diacetate methylates USP31. 1 / 1

1 |

➶

ctd

No evidence text available

29571894

Lead atom affects USP31

1 |

Lead atom decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

19921347

Hsa-miR-92a-3p affects USP31

1 |

Hsa-miR-92a-3p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-7-5p affects USP31

1 |

Hsa-miR-7-5p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

19073608

Hsa-miR-574-3p affects USP31

1 |

Hsa-miR-574-3p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-374a-5p affects USP31

1 |

Hsa-miR-374a-5p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-23b-3p affects USP31

1 |

Hsa-miR-23b-3p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-195-5p affects USP31

1 |

Hsa-miR-195-5p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-16-5p affects USP31

1 |

Hsa-miR-16-5p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-15b-5p affects USP31

1 |

Hsa-miR-15b-5p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-15a-5p affects USP31

1 |

Hsa-miR-15a-5p decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Fulvestrant affects USP31

1 |

Fulvestrant methylates USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31601247

Formaldehyde affects USP31

1 |

Formaldehyde increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Fenvalerate affects USP31

1 |

Fenvalerate increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

30307764

Ethyl methanesulfonate affects USP31

1 |

Ethyl methanesulfonate increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Endosulfan affects USP31

1 |

Endosulfan increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

29391264

Doxorubicin affects USP31

1 |

Doxorubicin decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

29803840

Deltamethrin affects USP31

1 |

Deltamethrin decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

34520793

Cyclosporin A affects USP31

1 |

Cyclosporin A increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

20106945

Crotonaldehyde affects USP31

1 |

Crotonaldehyde decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

20471460

Copper(II) sulfate affects USP31

1 |

Copper(II) sulfate increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

19549813

Cobalt dichloride affects USP31

1 |

Cobalt dichloride decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

19320972

Chlorpyrifos affects USP31

1 |

Chlorpyrifos increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

37019170

Butanal affects USP31

1 |

Butanal decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

26079696

Beta-lapachone affects USP31

1 |

Beta-lapachone increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

38218311

Benzo[a]pyrene diol epoxide I affects USP31

1 |

Benzo[a]pyrene diol epoxide I decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

20018196

Antirheumatic drug affects USP31

1 |

Antirheumatic drug increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

24449571

Acetamide affects USP31

1 |

Acetamide decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31881176

Abrine affects USP31

1 |

Abrine increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31054353

ZRANB1 affects USP31

1 |

ZRANB1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

35944360

YWHAZ affects USP31

1 |

YWHAZ binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

YWHAQ affects USP31

1 |

YWHAQ binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

YWHAH affects USP31

1 |

YWHAH binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

YWHAG affects USP31

1 |

YWHAG binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

YWHAE affects USP31

1 |

YWHAE binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

YWHAB affects USP31

1 |

YWHAB binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

VIRMA affects USP31

1 |

VIRMA binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

29507755

USP31 affects signal transduction

| 1

USP31 activates signal transduction. 1 / 1

| 1

➶

reach

"USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration."

38715330

USP31 affects positive regulation of NF-kappaB transcription factor activity

| 1

USP31 inhibits positive regulation of NF-kappaB transcription factor activity. 1 / 1

| 1

➶

eidos

24260525

USP31 affects immune response

| 1

USP31 activates immune response. 1 / 1

| 1

➶

reach

"By stabilizing key components of this pathway, USP31 may enhance immune evasion and contribute to the tumor’s ability to escape immune surveillance [71]."

39596229

USP31 affects evasion of host immune response

| 1

USP31 activates evasion of host immune response. 1 / 1

| 1

➶

reach

"By stabilizing key components of this pathway, USP31 may enhance immune evasion and contribute to the tumor’s ability to escape immune surveillance [71]."

39596229

USP31 affects cell population proliferation

| 1

USP31 activates cell population proliferation. 1 / 1

| 1

➶

reach

"USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration."

38715330

USP31 affects cell growth

| 1

USP31 activates cell growth. 1 / 1

| 1

➶

reach

38204265

USP31 affects cell cycle

| 1

USP31 activates cell cycle. 1 / 1

| 1

➶

reach

"We also observed that mutated USP31 could promote apoptosis but not cell cycle by flow cytometer analysis."

34184746

USP31 affects ZRANB1

1 |

ZRANB1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

35944360

USP31 affects YWHAZ

1 |

YWHAZ binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects YWHAQ

1 |

YWHAQ binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects YWHAH

1 |

YWHAH binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects YWHAG

1 |

YWHAG binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects YWHAE

1 |

YWHAE binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects YWHAB

1 |

YWHAB binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects VIRMA

1 |

VIRMA binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

29507755

USP31 affects Ubiquitin

| 1

USP31 activates Ubiquitin. 1 / 1

| 1

➶

reach

"The further characterization of the role of USP31 in TRAF-mediated signalling will require the inactivation of the usp31 gene in mice.The Ub–proteasome system is responsible for much of the regulated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16982211

USP31 affects USP31

| 1

USP31 inhibits USP31. 1 / 1

| 1

➶

reach

"Overexpression of mutated USP31 could reverse the effect in USP31 knockdown cell line."

34184746

USP31 affects UBC

1 |

UBC binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

29576527

USP31 affects TRIM36

1 |

TRIM36 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects SIRT1

1 |

USP31 binds SIRT1. 1 / 1

1 |

➶

biogrid

No evidence text available

34184746

USP31 affects SFN

1 |

SFN binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

USP31 affects RHOB

1 |

RHOB binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects OCLN

1 |

OCLN binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects Neoplasm Invasiveness

| 1

USP31 activates Neoplasm Invasiveness. 1 / 1

| 1

➶

reach

"USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration."

38715330

USP31 affects M

1 |

M binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

35337019

USP31 affects LYN

1 |

LYN binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects LUSC

| 1

USP31 activates LUSC. 1 / 1

| 1

➶

reach

"Immunofluorescence analysis illustrated that USP31 knockdown blocked the occurrence of LUSC autophagy."

38204265

USP31 affects KRAS

1 |

KRAS binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects IKBKB

1 |

USP31 decreases the amount of IKBKB. 1 / 1

1 |

➶

bel

16214042

USP31 affects HSP90beta

| 1

USP31 binds HSP90beta. 1 / 1

| 1

➶

reach

"We found that silencing of USP31, and silencing of both PKD1L3 and USP31, decreased EMCV RNA level at 3 days post-infection (Fig. 4B).3.3 PKD1L3 and USP31 interaction with eIF3c and HSP90beta."

40188851

USP31 affects HSP90AA1

1 |

HSP90AA1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34349018

USP31 affects GAPDH

1 |

GAPDH binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34349018

USP31 affects FMDV-IRES

| 1

USP31 inhibits FMDV-IRES. 1 / 1

| 1

➶

reach

"Silencing PKD1L3 and USP31 significantly suppressed FMDV-IRES activity (Fig. 2A) without inducing cytotoxicity (Fig. 2B)."

35468926

USP31 affects FMDV-

| 1

USP31 activates FMDV-. 1 / 1

| 1

➶

reach

"Silencing of PKD1L3 and USP31 significantly suppressed FMDV- and CSFV- activities in these assays, demonstrating these factors are required for the viruses to invade host cells."

40188851

USP31 affects EPHA2

1 |

EPHA2 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36976175

USP31 affects EIF3C

| 1

USP31 binds EIF3C. 1 / 1

| 1

➶

reach

"We found that silencing of USP31, and silencing of both PKD1L3 and USP31, decreased EMCV RNA level at 3 days post-infection (Fig. 4B).3.3 PKD1L3 and USP31 interaction with eIF3c and HSP90beta."

40188851

USP31 affects EGFR

1 |

EGFR binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

28065597

USP31 affects DNAJC5

1 |

DNAJC5 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

33957083

USP31 affects Carcinoma, Squamous Cell

| 1

USP31 activates Carcinoma, Squamous Cell. 1 / 1

| 1

➶

reach

"Deubiquitylase USP31 Induces Autophagy and Promotes the Progression in Lung Squamous Cell Carcinoma Cells by Stabilizing E2F1 Expression."

38204265

USP31 affects CTNNB1

| 1

USP31 leads to the deubiquitination of CTNNB1. 1 / 1

| 1

➶

reach

"USP31 inhibits ubiquitination of β-catenin by binding to it, stimulates the Wnt/β-- catenin pathway, activates glycolysis, and accelerates the biology of GCs, which are all demonstrated in this work."

38715330

USP31 affects CTDSPL

1 |

CTDSPL binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

27880917

USP31 affects CSFV-IRES

| 1

USP31 inhibits CSFV-IRES. 1 / 1

| 1

➶

reach

"Silencing PKD1L3 and USP31 significantly suppressed CSFV-IRES activity in both cell lines (Fig. 6A) without inducing cytotoxicity (Fig. 6B)."

35468926

USP31 affects CSFV-

| 1

USP31 activates CSFV-. 1 / 1

| 1

➶

reach

"Silencing of PKD1L3 and USP31 significantly suppressed FMDV- and CSFV- activities in these assays, demonstrating these factors are required for the viruses to invade host cells."

40188851

USP31 affects CDH1

1 |

CDH1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

37756605

USP31 affects CAV1

1 |

CAV1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects C11orf52

1 |

C11orf52 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

USP31 affects AGO2

1 |

AGO2 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

18461144

UBC affects USP31

1 |

UBC binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

29576527

Tobacco Smoke Pollution affects USP31

1 |

Tobacco Smoke Pollution increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

28065790

TRIM36 affects USP31

1 |

TRIM36 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

T-2 toxin affects USP31

1 |

T-2 toxin decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

31299295

Smoke affects USP31

1 |

Smoke decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

21095227

SIRT1 affects USP31

1 |

USP31 binds SIRT1. 1 / 1

1 |

➶

biogrid

No evidence text available

34184746

SFN affects USP31

1 |

SFN binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36931259

RHOB affects USP31

1 |

RHOB binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

PCB138 affects USP31

1 |

PCB138 decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

25510870

PCB 180 affects USP31

1 |

PCB 180 decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

25510870

PAX4 affects USP31

1 |

PAX4 decreases the amount of USP31. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

OCLN affects USP31

1 |

OCLN binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

MYC affects USP31

1 |

MYC decreases the amount of USP31. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MIR375 affects USP31

1 |

MIR375 decreases the amount of USP31. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20215506

M affects USP31

1 |

M binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

35337019

LYN affects USP31

1 |

LYN binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

LEF1 affects USP31

1 |

LEF1 decreases the amount of USP31. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

KRAS affects USP31

1 |

KRAS binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

K 7174 affects USP31

1 |

K 7174 increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

24086573

HSP90beta affects USP31

| 1

USP31 binds HSP90beta. 1 / 1

| 1

➶

reach

"We found that silencing of USP31, and silencing of both PKD1L3 and USP31, decreased EMCV RNA level at 3 days post-infection (Fig. 4B).3.3 PKD1L3 and USP31 interaction with eIF3c and HSP90beta."

40188851

HSP90AA1 affects USP31

1 |

HSP90AA1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34349018

HDAC_III affects USP31

| 1

HDAC_III leads to the acetylation of USP31. 1 / 1

| 1

➶

reach

"To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31."

34184746

GAPDH affects USP31

1 |

GAPDH binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34349018

FR900359 affects USP31

1 |

FR900359 phosphorylates USP31. 1 / 1

1 |

➶

ctd

No evidence text available

37730182

ESRRA affects USP31

1 |

ESRRA decreases the amount of USP31. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

EPHA2 affects USP31

1 |

EPHA2 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

36976175

EIF3C affects USP31

| 1

USP31 binds EIF3C. 1 / 1

| 1

➶

reach

"We found that silencing of USP31, and silencing of both PKD1L3 and USP31, decreased EMCV RNA level at 3 days post-infection (Fig. 4B).3.3 PKD1L3 and USP31 interaction with eIF3c and HSP90beta."

40188851

EGFR affects USP31

1 |

EGFR binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

28065597

Dietary Sucrose affects USP31

1 |

Dietary Sucrose increases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

26033743

Dietary Fats affects USP31

1 |

Dietary Fats decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

25016146

DNAJC5 affects USP31

1 |

DNAJC5 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

33957083

Cuprizon affects USP31

1 |

Cuprizon decreases the amount of USP31. 1 / 1

1 |

➶

ctd

No evidence text available

26577399

CTDSPL affects USP31

1 |

CTDSPL binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

27880917

CDH1 affects USP31

1 |

CDH1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

37756605

CAV1 affects USP31

1 |

CAV1 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

C11orf52 affects USP31

1 |

C11orf52 binds USP31. 1 / 1

1 |

➶

biogrid

No evidence text available

34079125

BMAL1 affects USP31

| 1

BMAL1 decreases the amount of USP31. 1 / 1

| 1

➶

reach

"We then transiently knocked down each of these transcriptional factors using siRNAs (Supplementary Fig. 9a) and observed that Bmal1 reduced the expression of Usp31 (Fig. 5b)."

38342927