IndraLab

Statements

USP31 inhibits NFkappaB. 5 / 5

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"USP31 and USP7 also inhibit NF-kappaB signaling by deubiquitinating K63 linked polyubiquitin chains [XREF_BIBR, XREF_BIBR]."

33498196

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"USP31 overexpression inhibited NF-kappaB activation mediated by TNFalpha and two members of the TNFR family, CD40 and LMP1, whereas it had no effect on the basal NF-kappaB activity."

16214042

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"USP31 also inhibited NF-kappaB activation mediated by two TRAF proteins (TRAF2 and TRAF6), as well as by the IKKbeta kinase."

16214042

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"YAP1 Mediated Suppression of USP31 Enhances NFkappaB Activity to Promote Sarcomagenesis."

29490948

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eidos

"USP31 and USP7 also inhibit NF-kappaB signaling by deubiquitinating K63-linked polyubiquitin chains [ 38,39 ] ."

33498196

USP31 activates NFkappaB. 2 / 2

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"The inhibition of NF-kappaB activation by USP31 was not due to a reduction of effector protein expression, since Western blot analysis revealed that the levels of all effector proteins were unaffected[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16214042

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"These results reinforce the notion that USP31 has a specific role in NF-kappaB activation induced by TRAFs and members of the TNFR family.The nuclear localization of USP31 and its implication in NF-ka[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16214042

USP31 is modified

5 | 1

USP31 is phosphorylated.

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USP31 is phosphorylated on T1056. 1 / 1

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hprd

No evidence text available

17287340

USP31 is phosphorylated on S1241. 1 / 1

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hprd

No evidence text available

19413330

USP31 is phosphorylated on S1052. 1 / 1

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hprd

No evidence text available

17287340

USP31 is phosphorylated on T5. 1 / 1

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hprd

No evidence text available

19413330

USP31 is acetylated.

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USP31 is acetylated on K1264. 1 / 1

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trips

"USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth."

34184746

USP31 is acetylated on K1236. 1 / 1

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hprd

No evidence text available

19413330

RELA affects USP31

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RELA binds USP31.

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USP31 binds RELA. 2 / 3

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"A candidate target of USP31 could be p65 and RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."

16214042

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biogrid

No evidence text available

16214042

RELA activates USP31.

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RELA activates USP31. 2 / 2

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"p65 and RelA is a possible target of USP31, since it is a major component of NF-kappaB and it is ubiquitinated and degraded by the proteasome in the nucleus [12]."

16214042

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"P65 and RelA is a possible target of USP31, since it is a major component of NF-kappaB and it is ubiquitinated and degraded by the proteasome in the nucleus [12]."

16214042

USP31 affects TRAF2

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USP31 inhibits TRAF2.

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USP31 inhibits TRAF2. 1 / 2

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eidos

"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."

24260525

USP31 binds TRAF2.

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TRAF2 binds USP31. 2 / 2

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biogrid

No evidence text available

16214042

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"To confirm that the interaction between TRAF2 and USP31 in mammalian cells occurs via the RING finger domain of TRAF2, as indicated by our two-hybrid results, a mutated form of TRAF2 with a RING finge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16214042

USP31 affects RELA

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USP31 binds RELA. 2 / 3

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"A candidate target of USP31 could be p65 and RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."

16214042

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biogrid

No evidence text available

16214042

Silver(0) affects USP31

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Silver(0) decreases the amount of USP31. 2 / 2

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ctd

No evidence text available

26014281

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ctd

No evidence text available

27131904

Paracetamol affects USP31

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Paracetamol increases the amount of USP31. 2 / 2

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ctd

No evidence text available

29067470

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ctd

No evidence text available

18700144

Aflatoxin B1 affects USP31

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Aflatoxin B1 increases the amount of USP31. 2 / 2

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ctd

No evidence text available

27153756

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ctd

No evidence text available

19770486

YAP1 affects USP31

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YAP1 inhibits USP31. 2 / 2

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"YAP1 promoted sarcomagenesis by inhibiting expression of ubiquitin specific peptidase 31 (USP31), a newly identified upstream negative regulator of NFkappaB signaling."

29490948

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"It is worth noting that YAP1 was shown to inhibit the negative regulatory factor of NF-κB USP31 and induce excessive tumor cell proliferation."

34659495

USP31 affects TRAF6

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USP31 inhibits TRAF6. 1 / 2

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eidos

24260525

USP31 affects CD40

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USP31 inhibits CD40. 1 / 2

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eidos

24260525

TRAF2 affects USP31

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TRAF2 binds USP31. 2 / 2

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biogrid

No evidence text available

16214042

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reach

16214042

SREBF1 affects USP31

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SREBF1 decreases the amount of USP31. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

Vinclozolin affects USP31

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Vinclozolin decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

23034163

Valproic acid affects USP31

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Valproic acid increases the amount of USP31. 1 / 1

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ctd

No evidence text available

23179753

Tris(1,3-dichloro-2-propyl)phosphate affects USP31

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Tris(1,3-dichloro-2-propyl)phosphate increases the amount of USP31. 1 / 1

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ctd

No evidence text available

26179874

Thioacetamide affects USP31

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Thioacetamide increases the amount of USP31. 1 / 1

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ctd

No evidence text available

23411599

Tetrachloromethane affects USP31

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Tetrachloromethane increases the amount of USP31. 1 / 1

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ctd

No evidence text available

31150632

Sunitinib affects USP31

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Sunitinib increases the amount of USP31. 1 / 1

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ctd

No evidence text available

31533062

Sodium arsenite affects USP31

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Sodium arsenite increases the amount of USP31. 1 / 1

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ctd

No evidence text available

21297353

Schizandrin B affects USP31

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Schizandrin B increases the amount of USP31. 1 / 1

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ctd

No evidence text available

31150632

Leflunomide affects USP31

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Leflunomide increases the amount of USP31. 1 / 1

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ctd

No evidence text available

28988120

Lead diacetate affects USP31

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Lead diacetate methylates USP31. 1 / 1

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ctd

No evidence text available

29571894

Lead atom affects USP31

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Lead atom decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

19921347

Hsa-miR-92a-3p affects USP31

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Hsa-miR-92a-3p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-7-5p affects USP31

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Hsa-miR-7-5p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

19073608

Hsa-miR-574-3p affects USP31

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Hsa-miR-574-3p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-375 affects USP31

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Hsa-miR-375 decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

20215506

Hsa-miR-374a-5p affects USP31

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Hsa-miR-374a-5p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-23b-3p affects USP31

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Hsa-miR-23b-3p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-195-5p affects USP31

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Hsa-miR-195-5p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-16-5p affects USP31

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Hsa-miR-16-5p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-15b-5p affects USP31

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Hsa-miR-15b-5p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-15a-5p affects USP31

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Hsa-miR-15a-5p decreases the amount of USP31. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Formaldehyde affects USP31

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Formaldehyde increases the amount of USP31. 1 / 1

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ctd

No evidence text available

23649840

Ethyl methanesulfonate affects USP31

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Ethyl methanesulfonate increases the amount of USP31. 1 / 1

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ctd

No evidence text available

23649840

Endosulfan affects USP31

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Endosulfan increases the amount of USP31. 1 / 1

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ctd

No evidence text available

29391264

Doxorubicin affects USP31

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Doxorubicin decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

29803840

Cyclosporin A affects USP31

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Cyclosporin A increases the amount of USP31. 1 / 1

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ctd

No evidence text available

20106945

Crotonaldehyde affects USP31

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Crotonaldehyde decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

20471460

Copper(II) sulfate affects USP31

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Copper(II) sulfate increases the amount of USP31. 1 / 1

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ctd

No evidence text available

19549813

Cobalt dichloride affects USP31

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Cobalt dichloride decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

19320972

Butanal affects USP31

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Butanal decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

26079696

Bisphenol A affects USP31

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Bisphenol A decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

25181051

Benzo[a]pyrene affects USP31

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Benzo[a]pyrene decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

19770486

Benzo[a]pyrene diol epoxide I affects USP31

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Benzo[a]pyrene diol epoxide I decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

20018196

Acetamide affects USP31

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Acetamide decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

31881176

Abrine affects USP31

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Abrine increases the amount of USP31. 1 / 1

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ctd

No evidence text available

31054353

Zoledronic Acid affects USP31

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Zoledronic Acid increases the amount of USP31. 1 / 1

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ctd

No evidence text available

20977926

USP31 affects positive regulation of NF-kappaB transcription factor activity

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USP31 inhibits positive regulation of NF-kappaB transcription factor activity. 1 / 1

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eidos

24260525

USP31 affects cell cycle

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USP31 activates cell cycle. 1 / 1

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"We also observed that mutated USP31 could promote apoptosis but not cell cycle by flow cytometer analysis."

34184746

USP31 affects apoptotic process

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USP31 activates apoptotic process. 1 / 1

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"We also observed that mutated USP31 could promote apoptosis but not cell cycle by flow cytometer analysis."

34184746

USP31 affects USP31

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USP31 inhibits USP31. 1 / 1

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"Overexpression of mutated USP31 could reverse the effect in USP31 knockdown cell line."

34184746

USP31 affects TNF

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USP31 inhibits TNF. 1 / 1

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24260525

USP31 affects GPX4

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USP31 binds GPX4. 1 / 1

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"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."

37011699

USP31 affects EGFR

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USP31 binds EGFR. 1 / 1

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biogrid

No evidence text available

28065597

USP31 affects CTDSPL

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CTDSPL binds USP31. 1 / 1

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biogrid

No evidence text available

27880917

Tobacco Smoke Pollution affects USP31

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Tobacco Smoke Pollution increases the amount of USP31. 1 / 1

1 |

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ctd

No evidence text available

28065790

T-2 Toxin affects USP31

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T-2 Toxin decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

31299295

Smoke affects USP31

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Smoke decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

21095227

PCB 180 affects USP31

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PCB 180 decreases the amount of USP31. 1 / 1

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ctd

No evidence text available

25510870

PAX4 affects USP31

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PAX4 decreases the amount of USP31. 1 / 1

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biopax:msigdb

No evidence text available

MYC affects USP31

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MYC decreases the amount of USP31. 1 / 1

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biopax:msigdb

No evidence text available

LEF1 affects USP31

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LEF1 decreases the amount of USP31. 1 / 1

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biopax:msigdb

No evidence text available

K 7174 affects USP31

1 |

K 7174 increases the amount of USP31. 1 / 1

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ctd

No evidence text available

24086573

HDAC_III affects USP31

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HDAC_III leads to the acetylation of USP31. 1 / 1

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"To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31."

34184746

GPX4 affects USP31

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USP31 binds GPX4. 1 / 1

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"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."

37011699