IndraLab

Statements

IRF9 binds USP18.
| 1 3
USP18 binds IRF9. 4 / 4
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reach
"Additionally, USP18 cannot bind IRF9 without STAT2 (Supplementary Fig. 6c)."
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sparser
"Nuclear USP18 is associated with ISGF3 transcription factor that bind to ISRE elements [ xref , xref ]."
37002195
sparser
"The coupled ISGF3-USP18 feedback system revealed in this study may function together with all the other mechanisms to maintain homeostasis in the responses to varying IFN signals."
32945770
sparser
"Additionally, USP18 cannot bind IRF9 without STAT2 (Supplementary Fig.  xref )."
36646704
IRF9 inhibits USP18.
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IRF9 inhibits USP18. 1 / 1
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"Low dose IFNα increases baseline STAT2 and IRF9 expression without strongly activating the negative feedback regulators SOCS1, SOCS3, and USP18, thereby hypersensitizing cells to further interferon stimulation (26)."
35471841
IRF9 increases the amount of USP18.
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IRF9 increases the amount of USP18. 1 / 1
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"However, most importantly, an IRF-9 depletion can impair ISG15 and USP18 expression [99,166], two molecules involved in type-I IFN response control.It is known that an overreactive response to interferons can lead to interferonopathies [169]."
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