The INDRA Database: Results

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading
phosphatidylinositol trisphosphate affects PDPK1
| 6 26
Phosphatidylinositol trisphosphate binds PDPK1. 10 / 29
| 6 23
reach
"The PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
23431468
reach
"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
28890686
reach
"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
27525138
reach
"Akt and PDK1 bind PIP3 and translocate to the membrane [XREF_BIBR, XREF_BIBR]."
20648549
reach
"In the membrane, the PDK1 and PIP3 complex phosphorylates AKT on thr308 XREF_BIBR."
19242559
reach
"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."
24284392
reach
"To further examine the regulation of Akt1 activation, we studied PDK1, an upstream regulatory kinase, whose PH domain binds to the PI 3-K product PIP3 with high affinity."
20163786
reach
"PDK1 and PKB and Akt bind to PIP3 and are recruited to the membrane XREF_BIBR, XREF_BIBR resulting in the phosphorylation of Akt by PDK1 and activation of Akt which leads to phosphorylation of both S6K and 4EBP1 XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
21203441
reach
"PIP3 is bound by AKT which facilities its activation by PDK1."
20058239
reach
"Second, ceramide blocks insulin stimulated Akt translocation to the PIP3 and PDK1 complex at the plasma membrane [XREF_BIBR, XREF_BIBR]."
23835113
Phosphatidylinositol trisphosphate binds PDPK1 and (PH) domain. 1 / 1
| 1
reach
"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."
21647530
Phosphatidylinositol trisphosphate binds PDPK1 and PH domains. 1 / 1
| 1
reach
"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
20333297
Phosphatidylinositol trisphosphate binds PDPK1 and PH domain. 1 / 1
| 1
reach
"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
26553931
PDPK1 affects phosphatidylinositol trisphosphate
| 6 26
Phosphatidylinositol trisphosphate binds PDPK1. 10 / 29
| 6 23
reach
"The PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
23431468
reach
"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
28890686
reach
"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
27525138
reach
"Akt and PDK1 bind PIP3 and translocate to the membrane [XREF_BIBR, XREF_BIBR]."
20648549
reach
"In the membrane, the PDK1 and PIP3 complex phosphorylates AKT on thr308 XREF_BIBR."
19242559
reach
"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."
24284392
reach
"To further examine the regulation of Akt1 activation, we studied PDK1, an upstream regulatory kinase, whose PH domain binds to the PI 3-K product PIP3 with high affinity."
20163786
reach
"PDK1 and PKB and Akt bind to PIP3 and are recruited to the membrane XREF_BIBR, XREF_BIBR resulting in the phosphorylation of Akt by PDK1 and activation of Akt which leads to phosphorylation of both S6K and 4EBP1 XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
21203441
reach
"PIP3 is bound by AKT which facilities its activation by PDK1."
20058239
reach
"Second, ceramide blocks insulin stimulated Akt translocation to the PIP3 and PDK1 complex at the plasma membrane [XREF_BIBR, XREF_BIBR]."
23835113
Phosphatidylinositol trisphosphate binds PDPK1 and (PH) domain. 1 / 1
| 1
reach
"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."
21647530
Phosphatidylinositol trisphosphate binds PDPK1 and PH domains. 1 / 1
| 1
reach
"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
20333297
Phosphatidylinositol trisphosphate binds PDPK1 and PH domain. 1 / 1
| 1
reach
"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
26553931
PDPK1 affects PH domains, and phosphatidylinositol trisphosphate
| 1
Phosphatidylinositol trisphosphate binds PDPK1 and PH domains. 1 / 1
| 1
reach
"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
20333297
PDPK1 affects PH domain, and phosphatidylinositol trisphosphate
| 1
Phosphatidylinositol trisphosphate binds PDPK1 and PH domain. 1 / 1
| 1
reach
"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
26553931
(PH) domain affects PDPK1, and phosphatidylinositol trisphosphate
| 1
Phosphatidylinositol trisphosphate binds PDPK1 and (PH) domain. 1 / 1
| 1
reach
"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."
21647530