A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

phosphatidylinositol trisphosphate affects PDPK1
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Phosphatidylinositol trisphosphate binds PDPK1. 6 / 29
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"The PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
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"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
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"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
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"Akt and PDK1 bind PIP3 and translocate to the membrane [XREF_BIBR, XREF_BIBR]."
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"In the membrane, the PDK1 and PIP3 complex phosphorylates AKT on thr308 XREF_BIBR."
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"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."
Phosphatidylinositol trisphosphate binds PDPK1 and (PH) domain. 1 / 1
| 1
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"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."
Phosphatidylinositol trisphosphate binds PDPK1 and PH domains. 1 / 1
| 1
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"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
Phosphatidylinositol trisphosphate binds PDPK1 and PH domain. 1 / 1
| 1
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"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
PDPK1 affects phosphatidylinositol trisphosphate
| 26
Phosphatidylinositol trisphosphate binds PDPK1. 6 / 29
| 23
reach
"The PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
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"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
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"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
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"Akt and PDK1 bind PIP3 and translocate to the membrane [XREF_BIBR, XREF_BIBR]."
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"In the membrane, the PDK1 and PIP3 complex phosphorylates AKT on thr308 XREF_BIBR."
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"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."
Phosphatidylinositol trisphosphate binds PDPK1 and (PH) domain. 1 / 1
| 1
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"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."
Phosphatidylinositol trisphosphate binds PDPK1 and PH domains. 1 / 1
| 1
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"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
Phosphatidylinositol trisphosphate binds PDPK1 and PH domain. 1 / 1
| 1
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"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
PDPK1 affects PH domains, and phosphatidylinositol trisphosphate
| 1
Phosphatidylinositol trisphosphate binds PDPK1 and PH domains. 1 / 1
| 1
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"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
PDPK1 affects PH domain, and phosphatidylinositol trisphosphate
| 1
Phosphatidylinositol trisphosphate binds PDPK1 and PH domain. 1 / 1
| 1
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"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
(PH) domain affects PDPK1, and phosphatidylinositol trisphosphate
| 1
Phosphatidylinositol trisphosphate binds PDPK1 and (PH) domain. 1 / 1
| 1
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"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."