"The PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
"Akt and PDK1 bind PIP3 and translocate to the membrane [XREF_BIBR, XREF_BIBR]."
"In the membrane, the PDK1 and PIP3 complex phosphorylates AKT on thr308 XREF_BIBR."
"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."