IndraLab

Statements

Phosphatidylinositol trisphosphate binds PDPK1. 10 / 35
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"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
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"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
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"Next, PIP3 binds to PDK1 and AKT proteins, leading to phosphorylation of AKT protein by PDK1 and activation of numerous enzymes."
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"To further examine the regulation of Akt1 activation, we studied PDK1, an upstream regulatory kinase, whose PH domain binds to the PI 3-K product PIP3 with high affinity."
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"PIP3 also binds to 3-phosphoinositide-dependent protein kinase 1 (PDPK1, also known as Protein Kinase B)."
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"Accordingly, PIP3 can interact with PDK1 to directly activate a variety of PKC isoforms."
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"Because PDK1 binding to PIP3 is required for Akt activation [43], these data suggest that Akt is not involved in PDK1 mediated tumorigenesis."
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"PIP3 binds to AKT and PDK1, causing PDK1 to phosphorylate Ser308 and Ser473 of the AKT protein, resulting in activation of AKT."
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"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."
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"PIP3 binds and recruits the kinases PDK1 and Akt, leading to Akt phosphorylation on T308 and S473 by PDK1 and mTORC2, respectively; both of these phosphorylation events are required for full Akt activation."
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"PDK1 and AKT bind the phospholipid PIP3 via their PH domains and are recruited to the plasma membrane."
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"AKT and PDK1, which contain PH domains can bind to PIP3."
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"Because the PH domain of PDK1 binds to PIP3 and activates Akt signaling, we examined the direct binding of the AMIGO2 CD (AMIGO2 CD) and the PDK1 PH domain (PDK1 PH)."
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"We also use this example to demonstrate an interaction between a lipid and a protein : PIP3 binds the pleckstrin homology (PH) domain of PDK1, recruiting PDK1 to the plasma membrane 83."
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