IndraLab

Statements

AKT1S1 binds MTOR. 10 / 76
9 1 | 1 31 30
sparser
"When PRAS40 is bound to mTOR, mTOR activity is reduced; in contrast, when mTOR detaches from PRAS40, mTOR is active ( xref )."
29729422
reach
"Increased p-raptor (S792) or PRAS40 binding to mTOR was inhibited by Compound C (XREF_FIG and XREF_FIG; XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), suggesting that AMPK mediates iron chelation increased p-raptor and PRAS40 binding to mTOR."
32541839
reach
"In human cells, PRAS40 binds to mTOR in an insulin dependent manner and may act as a negative regulator of TORC1 in the absence of insulin."
22068330
sparser
"To verify whether AMPK mediates increased p-raptor (S792) or PRAS40 binding to mTOR, IP against mTOR was performed after cells were treated with CPX or Dp44mT, with/without Compound C pretreatment."
32541839
sparser
"In the presence of EtOH, there was an increased interaction between PRAS40 and mTOR."
20127721
reach
"In the presence of EtOH, there was an increased interaction between PRAS40 and mTOR."
20127721
sparser
"Increased p-raptor (S792) or PRAS40 binding to mTOR was inhibited by Compound C (Figs. xref and xref ), suggesting that AMPK mediates iron chelation-increased p-raptor/PRAS40 binding to mTOR."
32541839
hprd
No evidence text available
17277771
sparser
"Genetic investigation of the factors associated with PRAS40 induction during mTOR inhibition identified amplification of EGFR, MDM2, and PDGFRA as more common in the non-responder subgroup, a finding not predicted from preclinical work."
18215108
trips
"PRAS40 binds the mTOR kinase domain and its interaction with mTOR is induced under conditions that inhibit mTOR signalling, such as nutrient or serum deprivation or mitochondrial metabolic inhibition."
17277771