IndraLab

Statements

Phosphatidylinositol trisphosphate binds AKT1. 1 / 4
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"Interestingly, recent findings show that phosphatidylinositol-3,4-bisphophate (PI34P2), also produced by PI3K, selectively recruits Akt2 at both the PM and early endosomes, whereas PIP3 specifically binds to Akt1 and Akt3 at the PM."
33659252
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"Whereas PIP3 engagement of PH domain reportedly promotes Akt activation [79], other studies indicate that PIP3 binding to the Akt1 PH domain per se does not induce Akt1 activation [80, 81]."
34419139
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"AKT1 binds PIP3 through its PH domain, resulting in translocation of AKT1 to the membrane."
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"This 5-mer peptide was expanded into a larger ligand that selectively blocks the E17K Akt1 interaction with its PIP3 (phosphatidylinositol (3,4,5)-trisphosphate) substrate."
25901825