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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Phosphatidylinositol trisphosphate binds AKT1 and PH domain. 2 / 2

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"Whereas PIP3 engagement of PH domain reportedly promotes Akt activation [79], other studies indicate that PIP3 binding to the Akt1 PH domain per se does not induce Akt1 activation [80, 81]."

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"AKT1 binds PIP3 through its PH domain, resulting in translocation of AKT1 to the membrane."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...