IndraLab

Statements

ELK1 is active.
9 29 | 1
ELK1 phosphorylated on S383 is active. 9 / 9
9 |
signor
"However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity."
8846788
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Elk-1 is a member of the e-twenty-six (ets) domain superfamily of transcription factors and has been traditionally associated with mitogen-induced immediate early gene transcription upon phosphorylation by mitogen activated protein kinases (erk/mapk)."
20727996
signor
"Phosphorylation on ser383 and ser389 of elk-1 by mapk enhances this basal binding but, most importantly, elk-1 exhibits new interactions with p300."
11145955
signor
"We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erk1 phosphorylates five c-terminal sites in elk-1 (s324,t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Transfection studies demonstrated that TAO2 stimulates phosphorylation of the TCF Elk1 on the major activating site, Ser383, and that TAO2 stimulates transactivation of Elk1 and the related TCF, Sap1."
12665513
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Subsequent studies with dominant negative elk-1, wild type, and variant gal4-elk-1 fusion proteins confirmed that phosphorylation of elk-1 at serines 383 and 389 in the c-terminal region of elk-1 is an important downstream target associated with activation of an sre by e2. Both e2 (er?-Dependent) and growth factors (er?-Independent) activated the sre in breast cancer cells via the ras/mapk pathway"
11145955
signor
"We demonstrate here that elk-1 is barely activated by a third subclass of map kinases (p38), most likely because the critical residues ser383 and ser389 are poorly phosphorylated by p38 map kinase."
9130707
ELK1 phosphorylated on S389 is active. 7 / 7
7 |
signor
"We find that the JNKs are the predominant Elk-1 activation domain kinases in extracts of UV-irradiated cells and that immunopurified JNK1/2 phosphorylate Elk-1 on the same major sites recognized by ERK1/2, that potentiate its transcriptional activity."
8846788
signor
"We demonstrate here that elk-1 is barely activated by a third subclass of map kinases (p38), most likely because the critical residues ser383 and ser389 are poorly phosphorylated by p38 map kinase."
9130707
signor
"However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity."
7651411
signor
"We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erki phosphorylates five c-terminal sites in elk-i (s324,t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity."
8846788
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
ELK1 phosphorylated on S389 and S383 is active. 6 / 6
6 |
biopax:pid
No evidence text available
biopax:pid
No evidence text available
9927426
biopax:pid
No evidence text available
biopax:pid
No evidence text available
8386592
biopax:pid
No evidence text available
8262053
biopax:pid
No evidence text available
7889942
Phosphorylated ELK1 is active. 3 / 3
3 |
signor
"The tcf protein elk-1 is phosphorylated by the jnk and erk groups of mitogen-activated protein (map) kinases causing increased dna binding, ternary complex formation, and transcriptional activation"
7618106
signor
"The tcf protein elk-1 is phosphorylated by the jnk and erk groups of mitogen-activated protein (map) kinases causing increased dna binding, ternary complex formation, and transcriptional activation"
7618106
signor
"Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1."
23616010
ELK1 phosphorylated on S324 is active. 3 / 3
3 |
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erk1 phosphorylates five c-terminal sites in elk-1 (s324,t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
ELK1 phosphorylated on S422 is active. 3 / 3
3 |
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erki phosphorylates five c-terminal sites in elk-i (s324,t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
ELK1 phosphorylated on T336 is active. 3 / 3
3 |
signor
"We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erki phosphorylates five c-terminal sites in elk-i (s324,t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
signor
"Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency."
7889942
ELK1 phosphorylated on S324, T336, S383, S389, and S422 is active. 2 / 2
2 |
biopax:pid
No evidence text available
7889942
biopax:pid
No evidence text available
11050086
ELK1 phosphorylated on T417 is active. 1 / 1
1 |
signor
"Activated hprp4 phosphorylates residue thr-417 on elk-1 resulting in elk-1 activation."
10799319
ELK1 bound to EP300 is active. 1 / 1
| 1
trips
"We present a novel mechanism of activating such complexes and show that pre-assembled Elk-1-p300 complexes become activated following Elk-1 phosphorylation by changes in Elk-1-p300 interactions rather than recruitment."
12514134
Tyrosine-phosphorylated ELK1 is active. 1 / 1
1 |
biopax:pid
No evidence text available
12824293
ELK1 is transcriptionally active.
5 9 |
ELK1 phosphorylated on S383 is transcriptionally active. 9 / 9
5 4 |
bel
"Phosphorylation of the C-terminal domain of Elk-1, especially at serine 383, is important for its transactivation activity."
9367995
bel
"Indeed, Ser383 plays a vital role, as mutation of Ser383 virtually eliminated hRev7-mediated enhancement of Elk-1 activity (Fig. 4D)."
17296730
bel
"Phosphorylation of the C-terminal domain of Elk-1, especially at serine 383, is important for its transactivation activity."
9367995
bel
"The NH(2) terminus of MKP-1 was also found to inhibit the activation of the serum response element (SRE) by preventing MAPK-mediated phosphorylation of the regulatory serine 383 residue on Elk-1."
15899879
bel
"Elk-1-dependent transactivation is regulated by phosphorylation at serine-383 and -389, and each of the MAPK has been shown to be competent to phosphorylate this nuclear factor at these residues in vitro (33, 34, 35, 36, 37)."
11441089
bel
"The NH(2) terminus of MKP-1 was also found to inhibit the activation of the serum response element (SRE) by preventing MAPK-mediated phosphorylation of the regulatory serine 383 residue on Elk-1."
15899879
bel
"Subsequent studies with dominant negative Elk-1, wild type, and variant GAL4-Elk-1 fusion proteins confirmed that phosphorylation of Elk-1 at serines 383 and 389 in the C-terminal region of Elk-1 is an important downstream target associated with activation of an SRE by E2."
11145955
bel
"Subsequent studies with dominant negative Elk-1, wild type, and variant GAL4-Elk-1 fusion proteins confirmed that phosphorylation of Elk-1 at serines 383 and 389 in the C-terminal region of Elk-1 is an important downstream target associated with activation of an SRE by E2."
11145955
bel
"Indeed, Ser383 plays a vital role, as mutation of Ser383 virtually eliminated hRev7-mediated enhancement of Elk-1 activity (Fig. 4D)."
17296730
Phosphorylated ELK1 is transcriptionally active. 4 / 4
4 |
bel
"This approach revealed a previously unrecognized transcriptional target of ELK-1, the human tissue plasminogen activator (tPA)."
15590693
bel
"MSK1 induction requires simultaneous activation of both ERK and p38 MAPK. Other downstream targets of p38 MAPK include transcription factors such as Elk1 and myocyte-enhancing factor (MEF) 2, whereby p38 MAPK directly phosphorylates nuclear substrates and augments their activity (Chen et al. 2001)."
15294035
bel
"Elk-1-dependent transactivation is regulated by phosphorylation at serine-383 and -389, and each of the MAPK has been shown to be competent to phosphorylate this nuclear factor at these residues in vitro (33, 34, 35, 36, 37)."
11441089
bel
"RIP2 directly phosphorylates and activates ERK2 in vivo and in vitro."
10559258
Serine-phosphorylated ELK1 is transcriptionally active. 1 / 1
1 |
bel
"GSK PI3K Phase 2, part 1: List of non-position specific phosphorylation effects on parent protein's activity, derived from existing causal assertions of position-specific phosphorylations on the parent protein activity."
ELK1 is transcriptionally inactive.
2 |
ELK1-W379A is transcriptionally inactive. 1 / 1
1 |
bel
"Mutation to alanine of S383, F378 or W379, which virtually abolishes transcriptional activation by Elk-1, does not affect phosphorylation of any sites tested."
10637505
ELK1-S383A is transcriptionally inactive. 1 / 1
1 |
bel
"Mutation to alanine of S383, F378 or W379, which virtually abolishes transcriptional activation by Elk-1, does not affect phosphorylation of any sites tested."
10637505