IndraLab

Statements

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"Hydroxychloroquine inhibits Toll like receptor pathways and minimizes flare, treats skin disease, and decreases the rate of autoantibody production [XREF_BIBR, XREF_BIBR,]."
27747587
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"Recently, HCQ was shown to inhibit activity of pDCs and B-cells by preventing Toll like receptor (TLR) 7- and TLR9 mediated signaling [79]."
24450381
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"By influencing several cellular pathways through different mechanisms, CQ and HCQ inhibit multiple endolysosomal functions, including autophagy, as well as endosomal Toll like receptor activation and calcium signalling."
32715647
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"Hydroxychloroquine, which inhibits Toll like receptor activation, has anecdotally been helpful as an adjunctive agent and has been shown to improve cutaneous and renal disease activity and prevent disease damage in lupus 107."
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"HCQ treats skin disease, minimizes flare-ups, and decreases auto-antibody production by inhibiting Toll-like receptor pathways [30]."
38291762
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"Chloroquine and hydroxychloroquine also reduce Toll-like receptor signaling, leading to both the direct and indirect inhibition of the immune system [10]."
35453248
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"In addition to its suppressive effects on viral replication, hydroxychloroquine inhibits Toll-like receptor 7/9–dependent inflammatory responses."
32624257
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"Thirdly, HCQ can block Toll-like receptor (TLR) signalling."
39286239
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"In the context of PE, HCQ is suggested to inhibit Toll-like receptor (TLR) activation through different mechanisms, reducing inflammation, improving endothelial function, and affecting placentation in preeclamptic patients."
38855757
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"Additionally, chloroquine and hydroxychloroquine inhibit the Toll like receptor (TLR) pathway; the TLR pathway is involved in pro inflammatory cytokine signaling [XREF_BIBR]."
| PMC