IndraLab

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"We found that MG132 caused an 80% inhibition of Cathepsin B, whereas lactacystin only slightly (< 10%) inhibited Cathepsin B. Therefore, the strong inhibitory effect of MG132 on degradation of EGF can be explained by the inhibitory effect of MG132 on Cathepsin B."

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"Surprisingly, MG132 also blocked cathepsin B, and at concentrations that were even lower than those required for blocking cathepsin C (XREF_FIG), indicating that MG132 blocks a wide range of proteases."

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