IndraLab

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"Therefore, CQ and HCQ in-vivo might actually promote inflammation and progression of sepsis by interfering with autophagy and clearance of oxidized molecules.It is also important to note that for trea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Also, HCQ was proposed to modulate the inflammatory response through its inhibition of the toll like receptors signal as well as the T and B cell receptors leading to inhibition of their cytokine production, including the interleukin (IL) -1 and IL-6 [XREF_BIBR, XREF_BIBR]."
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"Our findings of the protective effect of HCQ suggest a promising role of autophagy inhibition on HUA-induced renal tubular inflammation and abnormal urate excretion, and could thus inhibit the develop[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Another benefit of hydroxychloroquine is that it inhibits TLR3 activation and therefore also reduces the inflammatory response and development of coagulation disorders [308]."
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"Also , HCQ was proposed to modulate the inflammatory response through its inhibition of the toll-like receptors signal as well as the T and B cell receptors leading to inhibition of their cytokine production , including the interleukin ( IL ) -1 and IL-6 [ 13 , 14 ] ."
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"Combination therapy with MTX, sulfasalazine, and hydroxychloroquine also decreases CV risk by improving inflammation reduction, increasing HDL, lowering LDL, and improving the ratio of total cholesterol to HDL, as against MTX monotherapy or in combination with etanercept."
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"The discovery of significantly altered liver function made the treatment of the infection critical, requiring greater caution with regard to the titration of the antidepressant drugs prescribed.One problem we faced was discriminating between potential liver damage caused by SARS-CoV-2 and iatrogenic damage caused by hydroxychloroquine used experimentally to modulate the inflammatory response to the infection, or both mechanisms."
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"The mechanism of hydroxychloroquine and dexamethasone action may directly regulate the autoimmune-mediated inflammation of the fetal heart by reducing the level of maternal antibodies and translocating through the placenta, thereby preventing the immune damage of the fetal heart."
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"HCQ increases insulin sensitivity and reduces insulin resistance through its indirect effect by reducing inflammation [48]."
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"The autophagy inhibitor hydroxychloroquine can prevent the development of systemic inflammation in preeclampsia and spontaneous abortion by inhibiting lysosomal and extra-lysosomal TLR ( Seo et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In vitro models can support the development of new therapeutics targeting the endothelium and also assess the existing immunomodulatory drugs, such as hydroxychloroquine, in modulating the inflammation-driven endothelial prothrombotic phenotype."
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"Therefore, the aim of our work was to investigate whether HCQ is able to modulate the abnormal inflammatory response driven by RNA:DNA hybrids.Considering the noteworthy difficulties in obtaining primary cells from children affected by this rare disease, we used immortalized lymphoblastoid cell lines (LCLs): one from a patient carrying the RNASEH2A p.R108W + p.F230L mutations, one from a patient carrying the RNASEH2B p.A177T mutation and one from a healthy control."
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"Hydroxychloroquine reverses the prothrombotic state in a mouse model of antiphospholipid syndrome : Role of reduced inflammation and endothelial dysfunction."
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"We note that while some evidence exists for therapeutic efficacy of CQ and HCQ in mitigating morbidities associated with virus-induced inflammation and immuno-hyperactivity, abundant caution is necessary in expecting prophylactic efficacy in the light of therapeutic evidence."
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"The activity of HCQ in the context of virus induced inflammation, innate immune activity, and nascent adaptive responses creates a complex milieu that will require careful study to decipher and discern which patients, dosing, and stage of the disease may benefit from this intervention."
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"6 The immunomodulatory drug HCQ modulates the inflammation-induced prothrombotic phenotype on ECs."
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"The patient was treated with hydroxychloroquine and prednisolone, which led to a gradual improvement in both inflammation and pain.A C-spine MRI was performed, revealing evidence of degenerative spondylosis at the C5-6 level (Figure 1)."
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"Two potential pathways were inferred to be involved in the protective effect of hydroxychloroquine in CAD : (a) hydroxychloroquine may activate ERK5 (encoded by MAPK7) to prevent endothelial inflammation via inhibition of cell adhesion molecule expression 24; and (b) hydroxychloroquine may inhibit endosomal activation of NADPH oxidase in response to pro inflammatory agonists (TNF-alpha and IL-1beta) and may decrease production of pro inflammatory cytokines in stimulated immune cells 25."
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"Hydroxychloroquine prevented the induction of epigenetic modifications needed for trained immunity.81 Preoperative exercise therapy triggered an anti‐inflammatory trained immunity phenotype via metabolic reprogramming and led to attenuation of liver injury and inflammation from ischemia in mouse models.82 Sterile tissue injury trained the innate immune system, providing protection against subsequent infection in adult drosophila."
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"It is uncertain whether the relatively small sample size and short observation period decreased the likelihood of obtaining significant changes.Furthermore, research has demonstrated that HCQ can modulate the development of adipose tissue inflammation and suppress cytokine release [45]."
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"Mice with MC903 and OVA mediated EoE like inflammation were treated with hydroxychloroquine (HCQ), a lysosomotropic agent that prevents autophagic flux by impairing AV-lysosome fusion."
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"Additional risk factors may include longer duration of disease and lower likelihood of treatment with prednisone, cyclophosphamide, or hydroxychloroquine [XREF_BIBR], a combination that may promote persistent inflammation leading to vascular tissue damage and induction of CVD."
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"In RA, hydroxychloroquine is designed to interfere with the interaction between T helper cells and antigen-presenting macrophages that cause joint inflammation and decrease the production of pro-inflammatory cytokines, thus reducing the overall inflammatory response."
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"9 Besides its antiviral activity , HCQ modulates innate and adaptive immune cell activation , cytokine response , and inflammation ."
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"Hydroxychloroquine reverses the prothrombotic state in a mouse model of antiphospholipid syndrome : Role of reduced inflammation and endothelial dysfunction."
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"As expected, hydroxychloroquine was able to modulate the pro-inflammatory response to IL-1β comparable to chloroquine ( Fig. 2 A), which is in line with our previous work in dendritic cells [12] ."
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"Furthermore, hydroxychloroquine has been successfully used during decades for the management of rheumatologic diseases modulating inflammation and organ damage [XREF_BIBR]."
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"9 Besides its antiviral activity, HCQ modulates innate and adaptive immune cell activation, cytokine response, and inflammation."
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