IndraLab

Statements

Amodiaquine inhibits HNMT. 5 / 11
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"IC50 values for the inhibition of mouse kidney HNMT by amodiaquine and S-adenosyl-L-homocysteine were 1.67 and 11.8 microM, respectively."
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"Amodiaquine, quinacrine and 1,4-(tele)-methyl-HI weakly inhibited HMT activity ex vivo and they failed to alter HI levels in the rat brain."
3832018
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"Both peripheral (intraperitoneal) and central (intraventricular) administration of amodiaquine substantially reduces HNMT activity [47]."
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"In this perspective, the HNMT inhibitor amodiaquine prioritized by SAveRUNNER/GSEA analysis might likely be used to restore a proper histamine balance and ameliorate MS conditions.While the HNMT expression data that we presented would not exclude histamine as a possible mediator implicated in the pathogenesis of MS, the frequencies of HNMT genotypes and allelic variants do not differ significantly between MS patients and controls, and are also unrelated with the age of onset, gender, course, and risk for the disease [61]."
35683024
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"HNMT exhibits high substrate specificity for histamine and is inhibited by its reaction products, as well as by the SH-group reagents p-chloromercuribenzoate and N-ethylmaleimide and by the antimalarial drugs quinacrine and amodiaquine [XREF_BIBR]."
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