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Leupeptin inhibits CTSL. 8 / 9
1 | 8
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"Leupeptin and E-64 dose dependently inhibited both cathepsin B and cathepsin L activities, and pepstatin A strongly inhibited cathepsin D activity in rat kidney lysosomes."
10334387
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"Injection of leupeptin or E-64 into rats actually inhibits the activities of cathepsin B and cathepsin L in the lysosomal fraction of liver and results in inhibition of turnover rate of liver aldolase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7051771
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"SARS-CoV infection was blocked by specific inhibitors of the pH-sensitive endosomal protease cathepsin L. S-mediated entry into Vero E6 and 293T/hACE2 cells was blocked by leupeptin, Z-lll-FMK (an inhibitor of both CTSB and CTSL), and E64c (an inhibitor of cysteine proteases) [21]."
34239932
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"These results suggest that leupeptin treatment caused significant inhibition of the intracellular maturation of cathepsin L."
7581248
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"Previously [1] we found that administration of leupeptin or E-64 to rats inhibited the lysosomal cathepsin B and cathepsin L activity in their liver."
7020765
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"On the other hand, leupeptin (2 ~ M), a potent reversible inhibitor of most cysteine proteinases (15,21), completely inhibited the unmasking of sperm cathepsin L."
3348813
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"Leupeptin (LeuP; Thermo Fisher Scientific, 78435) was given to the cells to inhibit cysteine-cathepsins (e.g., CTSB and CTSL) and was used at 5 µM for 72 h. Generation of CTSD-deficient H4 cells."
35287553
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"Injection of leupeptin into rats [1] actually inhibits the activities of cathepsin B and cathepsin L in the lysosomal fraction of the liver cells."
7020765