IndraLab

Statements

Sotrastaurin inhibits ACE2. 5 / 5
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"∗P < 0.01 vs. 0, 2, 4, and 7.8 mM; ∗∗P < 0.05 vs. 0 and 2 mM; †P < 0.05 vs. 0 mM; n = 5.FIGURE 2: The pan-PKC inhibitor sotrastaurin reduces ACE2 shedding in mouse proximal tubular cells."
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"On the other hand, sotrastaurin (10-5 M) completely inhibited ACE2 shedding under conditions of high D-glucose (28 mM), to levels observed under basal conditions, with or without TAPI-1 (Figure 2C)."
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"In cells maintained in 7.8 mM D-glucose, ACE2 shedding was significantly inhibited by the pan-protein kinase C (PKC) competitive inhibitor sotrastaurin, but not by an inhibitor of ADAM17."
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"On the other hand, sotrastaurin (10 -5 M) completely inhibited ACE2 shedding under conditions of high D-glucose (28 mM), to levels observed under basal conditions, with or without TAPI-1."
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sparser
"In cells maintained in 7.8 mM D -glucose, ACE2 shedding was significantly inhibited by the pan-protein kinase C (PKC) competitive inhibitor sotrastaurin, but not by an inhibitor of ADAM17."
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