IndraLab

Statements

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": Psychiatric medications vulnerable mild CYP2D6 metabolism inhibition by chloroquine or hydroxychloroquine."
| PMC
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"HCQ may also inhibit CYP2D6 , interacting with a variety of different COVID-19 and non-COVID-19 medications ."
| PMC
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"In fact , chloroquine and hydroxychloroquine inhibit CYP2D6 , which metabolizes several antipsychotics , antidepressants , and antihistamines , while ritonavir inhibits CYP3A4 , actively involved in the metabolism of some macrolides , azole antifungals , antidepressants , and antihistamines ."
| PMC
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"The ability of CQ and HCQ to inhibit CYP2D6 might reduce the analgesic efficacy of opioids which are metabolised by CYP2D6 [123, 124]."
34306523
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"25 Last , both HCQ and chloroquine inhibit CYP2D6 , which may increase beta-blocker exposure and risk of bradycardia , PR interval prolongation , and AVN blockade ."
32706293
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"Moreover, chloroquine and hydroxychloroquine are mild inhibitors of CYP2D6, and have potential interactions with numerous psychotropic medications.Tocilizumab’s neuropsychiatric effects have not been widely studied in the context of COVID-19 treatment."
| PMC
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"22, 43 Hydroxychloroquine A moderate inhibitor of CYP2D6 and P-gp and caution may be required when co-administering comedications metabolized or transported by these pathways with a narrow therapeutic index."
32750131
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"Furthermore, our findings show that HCQ and its metabolites are inhibitors of CYP2D6, which likely explains the previously observed interaction between HCQ and metoprolol."
36446607
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"Both CQ and HCQ inhibit CYP2D6 activity through competitive mechanisms."
34028468
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"HCQ appears to inhibit CYP2D6 and can affect the levels of psychotropic medications dependent on CYP2D6 for their metabolism ."
32874009
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"HCQ appears to inhibit CYP2D6 and can affect the levels of psychotropic medications dependent on CYP2D6 for their metabolism."
32874009
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"Both CQ and HCQ inhibit CYP2D6 activity through competitive mechanisms."
34028468
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"Hydroxychloroquine and chloroquine inhibit CYP2D6 and may increase plasma concentration of metoprolol 48; a similar effect may be observed in carvedilol but has never been studied.Carvedilol is a nonselective beta blocker."
32515253
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"18 Chloroquine and hydroxychloroquine also inhibit CYP2D6 , which may increase beta-blocker exposure and risk of bradycardia , PR interval prolongation , and atrioventricular block ."
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"Hydroxychloroquine, by inhibiting the CYP2D6, leads to an increase in the serum concentration of beta-blockers."
32921718
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"Combined with the fact that HCQ and ritonavir directly inhibit CYP2D6 and CYP3A4 , respectively , there is a potential for QT prolongation culminating in torsades de pointes ( 102 ) ."
| PMC
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"[XREF_BIBR XREF_BIBR] Chloroquine and hydroxychloroquine are inhibitors of CYP2D6."
33912505
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"With increased use of these medications, physicians need to become knowledgeable of these drugs' neuropsychiatric side effects and interactions with psychiatric medications.Methods: Literature review was performed in PubMed from 1950-2020 regarding psychiatric topics and targeted pharmacological properties of chloroquine and hydroxychloroquine.Review: First, chloroquine and hydroxychloroquine may mildly inhibit CYP2D6 metabolism of psychiatric medications, and psychiatric medications that interfere with CYP2D6 or CYP3A4 activity could alter chloroquine and hydroxychloroquine levels."
| PMC
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"Hydroxychloroquine and chloroquine inhibit CYP2D6 and may increase plasma concentration of metoprolol 48; a similar effect may be observed in carvedilol but has never been studied."
32515253
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"Antirheumatic chloroquine , and hydroxychloroquine , inhibit CYP2D6 , thus requiring adjusting galantamine and donepezil [ 165 ] ."
32925078
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"Antirheumatic chloroquine, and hydroxychloroquine, inhibit CYP2D6, thus requiring adjusting galantamine and donepezil [165]."
32925078
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"REVIEW: First, chloroquine and hydroxychloroquine may mildly inhibit CYP2D6 metabolism of psychiatric medications, and psychiatric medications that interfere with CYP2D6 or CYP3A4 activity could alter chloroquine and hydroxychloroquine levels."
| PMC
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"18 Chloroquine and hydroxychloroquine also inhibit CYP2D6, which may increase beta-blocker exposure and risk of bradycardia, PR interval prolongation, and atrioventricular block."
32282502
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"Hydroxychloroquine is metabolized by CYP2D6, CYP3A4, and CYP2C8, and inhibits CYP2D6, while its metabolites also inhibit CYP3A in vitro."
36446607
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"Both CQ and HCQ were reported to inhibit CYP2D6 activity [ 58 ] ."
33542445
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"[XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR] Ritonavir as well as hydroxychloroquine increases the effects of tetrabenazine by inhibiting hepatic enzyme CYP2D6 metabolism."
33912505
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"Hydroxychloroquine is metabolized by CYP2D6 , CYP3A4 , and CYP2C8 , and inhibits CYP2D6 , while its metabolites also inhibit CYP3A in vitro ."
36446607
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"Hydroxychloroquine is a weak inhibitor of CYP2D6 and of the P-gp efflux protein, requiring intensified monitoring when used concomitantly with narrow-window drugs having this metabolic pathway: gefitinib, tamoxifen (Table 2C) ."
| PMC
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"Furthermore, CQ and HCQ can inhibit CYP2D6 activity thus suppressing the metabolism of their own and other drugs metabolised by the enzyme."
34104100
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No evidence text available
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