IndraLab

Statements

Hydroxychloroquine decreases the amount of IL6. 22 / 22
| 22
reach
"Hydroxychloroquine, a drug that has been investigated in COVID-19, is also known to modulate the cytokine response and reduce IL-6 levels [89], though recent observational studies have not identified a clear benefit in COVID-19 [90]."
| PMC
reach
"Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction : The randomized, double-blind, placebo controlled OXI pilot trial."
33961943
reach
"Similar remarks can apply to HCQ, which has been shown to improve skeletal muscle insulin sensitivity, enhance systemic glucose clearance, and concomitantly reduce circulating IL-6 levels in insulin-resistant adults [93]."
35629988
reach
"HCQ was reported to inhibit the release of IL-6, IL-1β and TNF-α (108–110)."
34664677
reach
"HCQ was reported to inhibit the release of IL-6, IL-1β and TNF-α (108) (109) (110) ."
34664677
reach
"In contrast to lopinavir and ritonavir, chloroquine and hydroxychloroquine + azithromycin downregulated the expression of TNF and IL6."
32920000
reach
"HCQ decreased IL-6 levels (p = 0.02) but not placebo (p = ns)."
33694220
reach
"5 Chloroquine/HCQ reduces the secretion of the proinflammatory cytokines, in particular the Th1 cytokines, namely interleukin (IL)-1, IL-6 tumor necrosis factor-α (TNFα), and interferon-gamma (IFNγ), 27 by the alveolar macrophages, and thus may have a role in reducing the peak inflammatory response in COVID-19."
32373183
reach
"By deacidifying endolysosomes and Golgi, CQ and HCQ could reduce the secretion of, for example, the proinflammatory cytokine TNF-α, IL-1β and IL-6."
32629149
reach
"In another single-arm study, administration of hydroxychloroquine to HIV infected persons who experienced suboptimal CD4 T-cell gains after highly active antiretroviral therapy (HAART) resulted in decreased levels of T-cell activation and decreased levels of inflammatory cytokines IL-6 and TNF in plasma."
22951442
reach
"Additionally, in a monocytic cell line, hydroxychloroquine attenuated TNF-alpha and IL6 expression in response to IL-1beta and TNF-alpha stimulation, respectively 46."
30002366
reach
"Interestingly, HCQ treatment has been shown to control the overproduction of IL-1β and GM-CSF in acute rheumatic fever (Kim et al. 2018) and to reduce the level of IL-6 in patients with rheumatoid arthritis (Batun-Garrido et al. 2018 )."
32415419
reach
"Yu and colleagues reported that HCQ treatment could reduce serum interleukin-6 (IL-6) levels in COVID-19 patients [8]."
34384388
reach
"Hydroxychloroquine can also reduce salivary and serum levels of IL-6, a key component of the senescence associated secretory phenotype (SASP) in chronic inflammatory diseases, such as Sjogren 's syndrome (49)."
32849658
reach
"HCQ treatment significantly decreased the levels of IL-6 in about 5 (4-8) days, *P<0.05 (A)."
32418114
reach
"This notion, in fact, was partially endorsed by the new results from a multicenter, randomized, double-blind, placebo-controlled OXI pilot trial among 125 patients with MI in Finland, which indicated that early administration of HCQ within 48 h after MI (300 mg once daily for 6 months) significantly reduced serum levels of interleukin-6 (IL-6), a key pro-inflammatory marker and did not cause any significant adverse events [133]."
36036333
reach
"For patients with IL-6 levels lower than 60 pg mL -1 before treated with HCQ, HCQ decreased IL-6 levels from 12.8 (8.2-23.5) pg mL -1 to 3.5(2.7-5.6) pg mL -1 after 5 days, and reached 3.0 (2."
32418114
reach
"Among the 51 patients enrolled in the study, HCQ treatment led to significantly reduced serum levels of TNF-α, IL-6, IL-8, VEGF-A, IL-1ra, and IL-2 (p < 0.0001; p = 0.0006; p = 0.0460, p = 0.0177; p < 0.0001; p = 0.0282, respectively) and to decreased (but not significantly) levels of MIP-1α (p = 0.0746)."
35715525
reach
"Tang et al. [25] found that HCQ inhibited the expression levels of IL-1β, IL-6, and TNF-α to protect against ischemia/reperfusion (I/R)-induced renal injury, which is consistent with our observations."
35346242
reach
"For patients with IL-6 levels higher than 60 pg mL -1 , HCQ treatment decreased IL-6 level from 100.0 (62.6-189.4) pg mL -1 to 28.4 (10.9-59.3) pg mL -1 after 5 days' treatment, and reached 9.8 (5.5-24.6) pg mL -1 after 10 days' treatment."
32418114
reach
"Hydroxychloroquine can also reduce salivary and serum levels of IL-6, a key component of the senescence associated secretory phenotype (SASP) in chronic inflammatory diseases, such as Sjogren 's syndrome."
32849658
reach
"10, 11 Treatment with HCQ also lowered IL-6 level in HIV patients, suggesting the agent may have immunosuppressive properties helpful in the prevention or treatment of cytokine storm associated with severe COVID-19 disease."
| DOI