IndraLab

Statements

Hydroxychloroquine activates doxycycline. 8 / 8
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"Hydroxychloroquine enhances the activity of doxycycline in vitro by increasing the pH of the phagolysosomes within the macrophages."
18291339
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"It is worth noting that the activity of carbenicillin, vancomycin, ofloxacin, clarithromycin, tigecycline, nisin, and hydroxychloroquine when combined with doxycycline only marginally enhanced doxycycline activity and their anti-persister activities were not as effective as when they were combined with daptomycin (XREF_TABLE)."
25806811
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"In fact, HCQ was shown to increase the phagolysosomal compartment 's pH by improving the bactericidal activity of doxycycline [125,126]."
33202656
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"Alkalinizing agent (hydroxychloroquine) combined with quinolones and prolonged administration can restore the efficacy of doxycycline against C. burnetii and effectively reduce the recurrence rate of chronic Q fever."
39040390
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"Hydroxychloroquine potentiates the bactericidal activity of doxycycline by alkalinizing the vacuolar pH [XREF_BIBR]."
29416805
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"On the other hand, HCQ was then added at a concentration of 6 μg/mL to each increased levels of AZI i.e. 0.2, 2, 10, 100, and 400 μg/mL to produce HCQ 6 μg/mL + AZI.Fig 8: The cytotoxicities of Hydroxychloroquine (HCQ) and Doxycycline (DOXY) as a single drug (left) and dual drug combination in constant and non-constant ratios (right) analysed by using CompuSyn Software (n = 3)."
34143818
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"The hydroxychloroquine promotes the alkalinization of the phagolysosome and enhances the efficacy of the doxycycline."
22285690
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"The preferred treatment is doxycycline, and hydroxychloroquine is often added to potentiate the therapeutic effect of doxycycline in chronic or disseminated infections."
40208119