IndraLab

Statements

Hydroxychloroquine inhibits INS. 23 / 23
| 3 20
reach
"Subsequently, another group of researchers pointed out that oral treatment with HCQ (6.5 mg/kg/day) for 12 weeks lowered FBG, OGTT, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and raised β-cell function in rats fed with high-fat diet containing 46% fat, 20.3% protein, and 24% carbohydrate."
34104100
reach
"HCQ inhibits the degradation of insulin enhancing the metabolic effects of the hormone to improve insulin sensitivity [44]."
32190699
reach
"By increasing the intracellular pH, Hydroxychloroquine inhibits various insulin degrading enzymes [XREF_BIBR] and thus inhibits insulin degradation [XREF_BIBR]."
32594451
reach
"The metabolic effect of HCQ is reducing dissociation of insulin from its receptor (tyrosine kinase) and increase the biologic half-life of insulin receptor complex which prolongs the action of insulin [16]."
32190699
reach
"HCQ seemed to decrease insulin resistance and incidence of CVD, but data were too few for meta-analysis."
28970215
reach
"Hydroxychloroquine was found to significantly reduce insulin metabolism in the cytosolic fraction of livers of both healthy and diabetic animals."
10072192
reach
"When HCQ was combined with insulin for 6 months, the glycated hemoglobin decreased significantly compared to placebo, and the insulin dose had to be reduced by 30% in the HCQ group [41]."
21221847
reach
"Hydroxychloroquine also reduces pro inflammatory cytokines, notably TNF-alpha and IL-6, and decreases insulin resistance."
| PMC
reach
"Hydroxychloroquine in lupus patients, reduces disease activity, cardiovascular risk, insulin resistance, thromboembolic events, infection risk and mortality XREF_BIBR - XREF_BIBR, and this drug should not be discontinued during the perioperative period."
28658439
reach
"HCQ inhibits the degradation of insulin, which enhances the metabolic effects and improves insulin sensitivity [56]."
36036333
reach
"Data from experimental models [XREF_BIBR] and a case report [XREF_BIBR] suggest that chloroquine, but not HCQ, may decrease insulin clearance."
26197707
reach
"Hydroxychloroquine has been reported to reduce insulin requirements in refractory type II diabetes by an average of 30%."
9918262
reach
"Hydroxychloroquine may be able to partially reduce the post-receptor increased insulin clearance, accelerating insulin stimulated glucose transport which leads to better management of the disease."
10072192
reach
"54 HCQ may reduce insulin requirements in patients with insulin‐dependent DM by up to 30%, 53 with concomitant reduction in haemoglobin A1c levels (1–3%)."
35969110
reach
"Furthermore, animal experiments have shown that both chloroquine and HCQ can protect β cells and reduce insulin clearance in vitro [37, 38]."
39748269
reach
"Thus, hydroxychloroquine therapy in COVID-19 may lead to hypoglycemia since this drug reduces insulin degradation and improves insulin storage with augmentation of peripheral glucose metabolism (59)."
34124187
reach
"The use of hydroxychloroquine improved lipid profiles and reduced incident diabetes and CVD as well as insulin resistance in RA [XREF_BIBR]."
32550295
reach
"One possible explanation for the glucose-lowering effect of HCQ may be that HCQ stabilizes intracellular lysosomes and slows the breakdown of the internalized insulin-receptor complex."
27372847
reach
"This would imply that HCQ reduces clearance of insulin, and not that it increases its secretion [XREF_BIBR]."
32612666
eidos
"HCQ improves insulin sensitivity and reduces insulin degradation [ 27 ] ."
32844224
eidos
"Hydroxychloroquine decreases insulin degradation at the cellular level , increases intracellular insulin accumulation , and stimulates insulin-mediated glucose transport [ 27 ] ."
32837091
eidos
"HCQ inhibits the degradation of insulin , which enhances the metabolic effects and improves insulin sensitivity [ 56 ] ."
36036333
reach
"Indeed, in patients with SLE, hydroxychloroquine reduces disease activity, CV risk, insulin resistance and thromboembolic events; therefore, in the perioperative period, it should not be discontinued and could even be protective [XREF_BIBR - XREF_BIBR]."
29556907