IndraLab

Statements

Hydroxychloroquine inhibits IL17A. 11 / 12
| 3 8
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"9 Previous reports revealed that HCQ inhibits the differentiation of Th-17 cells and decreased the release of IL-17 from the experience of treating systemic lupus erythematosus."
| PMC
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"Furthermore, Yang et al. found that HCQ reduced the differentiation of Th17 cells and the production of IL-17A in vitro using PBMCs from SLE patients (13)."
35401507
eidos
"Contrarily , CQ and HCQ inhibited IL-1 , IL-2 , IL-6 , IL-17 , and IL-22 as well as PGs ( Table 1 ) [ 61 , 98 , 99 ] ."
33062720
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"The exact mechanism via which HCQ decreased IL-6 and IL-17 as well as IL-22 concentrations is still a matter of debate ."
33062720
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"CONCLUSIONS Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication."
23778483
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"Hydroxychloroquine, a drug often used in the treatment of SLE with ability to reduce sensitivity of the skin to UV exposure, can inhibit Th17 cell expansion and IL-17 production [XREF_BIBR]."
27597882
eidos
"Contrarily , CQ and HCQ inhibited IL-1 , IL-2 , IL-6 , IL-17 , and IL-22 as well as PGs ( Table 1 ) Tumor necrosis factor ( TNF ) is a pleiotropic cytokine that partakes in crucial regulatory roles in immune and inflammatory responses via cell surface receptors [ 59 , 101 ] ."
33062720
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"Furthermore, considering that the levels of systemic inflammation biomarkers significantly decreased among good responders in our study, it is notable that methotrexate alone or in combination with sulfasalazine reduces circulating levels of IL-6 [XREF_BIBR], and hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production from PBMC [XREF_BIBR]."
26353115
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"Hydroxychloroquine also has immunomodulatory effects, and has been reported to decrease IL-1, IL-2, IL-6, IL-17, IL-22, IFN-alpha, and tumor necrosis factor [XREF_BIBR, XREF_BIBR]."
| PMC
reach
"Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication."
23778483
reach
"In vitro, HCQ inhibited Th17 cell proliferation and differentiation, as well as IL-17 production."
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