IndraLab

Statements


TP53 binds MDM2 and PTK2. 11 / 11
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sparser
"The authors demonstrate the regions of FAK that bind Mdm-2 and p53."

sparser
"Another group showed that FAK binds p53 and also that FAK binds Mdm-2 to increase ubiquitination and degradation of p53 [ xref ]."

sparser
"Inhibition of FAKp53 and MDM2p53 interactions were evaluated in five mesothelioma cell lines including MESO924, MESO257, MESO296, MESO428, and JMN1B, at 48 h after treatment with nutlin-3 and/or at 72 h post infection with FAK shRNA ( xref )."

sparser
"The same strategy can be used to target interaction with FAK and p53, FAK and Mdm-2 and combination therapy approaches can be applied."

sparser
"The recent report confirmed direct binding of the N-terminal domain of FAK with p53 and also found interaction of FAK and Mdm-2 providing a novel mechanism of FAK-Mmd-2-mediated ubiquitination of p53 in the nucleus [ xref ]."

sparser
"The recent report confirmed direct binding of the N-terminal domain of FAK with p53 and also found interaction of FAK and Mdm-2 providing a novel mechanism of FAK-Mmd-2-mediated ubiquitination of p53 in the nucleus ( xref )."

sparser
"NF2 regulates the FAKp53 and MDM2p53 interaction."

sparser
"Our results also indicate that NF2 regulates the interaction of FAKp53 and MDM2p53."

sparser
"A Study has found that FAK negatively regulated p53 expression in mesothelioma cell lines and NF2 regulated the interaction of FAKp53 and Mdm2p53 [ xref ]."

sparser
"Combination inhibition of the FAKp53 and MDM2p53 interactions suppressed cell viability in mesothelioma."

sparser
"The same strategy was used to target interaction with Mdm-2 and FAK (M-drugs) and p53 and FAK (P drugs)."