IndraLab

Statements

TNF inhibits CYLD. 4 / 4
| 4
reach
"Inhibiting CASPASE-8 leads to CYLD dependent necroptosis caused by the TNF produced in response to TLR4 ligation."
27264187
reach
"These results strongly suggested that, in the LUBAC- and TNFα-stimulated cells, Subquinocin enhanced the NF-κB signaling by inhibiting CYLD."
31898971
reach
"Another protein, CYLD which deubiqitinates TRAF6, and is negatively regulated by specific TNF receptors, might play a role of a silencer of EDAR signaling, since mutations in CYLD predispose not only to skin tumors (cylidromatosis), but also to the development of tumors of eccrine sweat glands and hair follicles."
26294279
reach
"This model is consistent with the recent discovery that caspase 8 mediated cleavage of CYLD limits TNF induced programmed necrosis [XREF_BIBR], since caspase 8 is present in the necrosome, but not the TNFR-1 complex."
24098568