IndraLab

Statements

Dexamethasone decreases the amount of IRS1. 9 / 10
4 | 5
ctd
No evidence text available
22733784
ctd
No evidence text available
19852296
reach
"It is important to note that elevated expression of PIK3R1 is found in patients with insulin resistance.Treating C2C12 myotubes with dexamethasone (Dex), a synthetic GC, reduces the total IRS-1 level,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23523565
ctd
No evidence text available
20032058
reach
"Thus, both insulin and dexamethasone down-regulate IRS-1 expression at the posttranscriptional level; with insulin this is probably due to an effect on protein half-life, whereas with dexamethasone the effect is due to a change in the half-life of IRS-1 mRNA."
8544845
reach
"Dexamethasone has been found to reduce the expression and phosphorylation of the IRS-1, PI3K, and protein kinase B (PKB)/Akt both in L6 skeletal muscle cells and in rat skeletal muscle [87,88]."
29530386
reach
"As reported previously XREF_BIBR, XREF_BIBR, dexamethasone reduced IRS-1 protein levels."
29259227
ctd
No evidence text available
18812026
reach
"Dexamethasone treatment decreased the expression of insulin receptor substrate 1 (by approximately 40%; P < 0.05) and PKB (by approximately 20%; P < 0.05) in omental but not in s.c. adipocytes."
15181089