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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to HTT increases the amount of TP53. 3 / 3

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"Mutant huntingtin (mHtt) with expanded polyglutamine (polyQ) binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity in neuronal cultures."

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"Mutant huntingtin interacts with p53, a transcription factor induced in response to DNA damage, and increases the levels and activity of p53 in mouse striatal cells, and in striatum and cerebral cortex from HD patients and R6/2 transgenic mice [XREF_BIBR, XREF_BIBR]."

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"Mutant huntingtin binds to p53 and upregulates the levels of nuclear p53 as well as p53 transcriptional activity in neuronal cultures."

19622387

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

TP53 bound to HTT increases the amount of TP53. 3 / 3

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