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LSM-36909 decreases the amount of IRS1. 3 / 3
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"Treatment of HepG2 and SMMC-7721 cells with 0.32 microM and 0.64 microM of AFB1 did not decrease IRS1 levels."

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"Our current study demonstrates that AFB1 up-regulates IRS2 but down-regulates IRS1 levels in hepatoma cells, leading to a shift in IRS1 and IRS2 expression towards a high IRS2 and IRS1 ratio."

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"AFB1 also induced a decrease in the levels of IRS1, but an increase in the levels of IRS2 (XREF_FIG)."