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Phosphorylated AKT increases the amount of MDM2. 1 / 1
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"Inhibition of AKT phosphorylation with phosphatidylinositol-3-kinase (LY294002) decreased MDM2 levels concomitantly with upregulation of p53, providing evidence that H. pylori inhibits p53 through the AKT-MDM2 signaling."