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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to CDKN2A increases the amount of TP53. 1 / 1

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"It is possible that small changes in p53 levels activated by PIM1 stabilization of the Mdm2 and ARF complex could be driving increases in transcription of p21, or, as our earlier work suggested, that other signaling pathways (i.e., PKC) possibly regulated by PIM1 could be playing a role in modulating p21 mRNA levels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...