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"This evidence may suggest that DNA hypomethylation of the p53 gene contributes to the enhanced p53 expression and causes abnormal apoptosis in lupus patients, a notion that needs further investigation.Several studies have demonstrated that methyl-CpG-binding domain 4 (MBD4) can be recruited by methylated DNA and thereby leading to the recruitment of histone modifying and chromatin-remodeling complexes to methylated sites [38,39]."