IndraLab

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Isotretinoin decreases the amount of IRS1. 2 / 2
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"IRS-1 expression is negatively regulated by all-trans retinoic acid (ATRA), which arrests the growth of ovarian carcinoma cells in G 0 -G 1 [XREF_BIBR]."

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"We found that all-trans retinoic acid (RA) decreases IRS-1 protein levels in MCF-7, T47-D, and ZR75.1 breast cancer cells, which are growth arrested by RA, but not in the RA resistant MDA-MB-231 and MDA-MB-468 cells."