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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNS2 decreases the amount of IRS1. 2 / 2

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"C1-Ten reduces IRS-1 protein levels via its PTPase activity 3."

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"Silencing of TNS2 markedly increased the activated forms of IRS1 (human pS616, pY612, or mouse pS612, pY608), Akt (pS473), Mek (pS217/221), and Erk (pT202 and pY204), as well as IRS1 protein levels, suggesting that TNS2 negatively regulated these pathways."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...