IndraLab

Statements


TNS2 decreases the amount of IRS1. 2 / 2
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"C1-Ten reduces IRS-1 protein levels via its PTPase activity 3."

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"Silencing of TNS2 markedly increased the activated forms of IRS1 (human pS616, pY612, or mouse pS612, pY608), Akt (pS473), Mek (pS217/221), and Erk (pT202 and pY204), as well as IRS1 protein levels, suggesting that TNS2 negatively regulated these pathways."