IndraLab
Statements
Phosphorylated TP53 activates apoptotic process. 6 / 6
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6
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"Western blot showed that the protein levels of CDCA2 treated with CDCA2 Si-1/2 were significantly downregulated compared with those of the NC group, and the levels of p53, phosphorylated p53 (p-p53), and the downstream target proteins, PUMA and NOXA, controlling apoptosis, and apoptosis-related protein cleaved-caspase3 were significantly upregulated (
Figure 8B
), suggesting that silencing CDCA2 promoted apoptosis through activation of the p53-PUMA/NOXA signaling pathway."
reach
"Acute hyperglycemia on healthy platelets induces phosphorylated p53 mediated mild mitochondrial dysfunction and damage, mild ROS increases, and minimal apoptosis, in part due to the protective effects of increased levels of Bcl-X L in normal platelets as compared to DM (Tang etal, 2011, 2014)."