IndraLab

Statements


Phosphorylated TP53 activates apoptotic process. 6 / 6
| 6

reach
"During infection, the phosphorylated p53 is functionally active to induce apoptosis along with the expression of p21 and mdm2 [XREF_BIBR]."

reach
"As SOCS1 links cytokine signaling to p53, we detected the level of the phosphorylated p53 in the IFN-gamma induced HT-29 cell apoptosis model in vitro and found that the expression pattern of phosphor[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Because the phosphorylated p53 accumulated induce chondrocytes apoptosis or senescence under the stimulation of nitric oxide (NO), IL-1β, and mechanical stress in OA, we believe TP53 may involve in the above cell compositions and molecular functions [46, 47]."

reach
"Western blot showed that the protein levels of CDCA2 treated with CDCA2 Si-1/2 were significantly downregulated compared with those of the NC group, and the levels of p53, phosphorylated p53 (p-p53), and the downstream target proteins, PUMA and NOXA, controlling apoptosis, and apoptosis-related protein cleaved-caspase3 were significantly upregulated ( Figure 8B ), suggesting that silencing CDCA2 promoted apoptosis through activation of the p53-PUMA/NOXA signaling pathway."

reach
"Acute hyperglycemia on healthy platelets induces phosphorylated p53 mediated mild mitochondrial dysfunction and damage, mild ROS increases, and minimal apoptosis, in part due to the protective effects of increased levels of Bcl-X L in normal platelets as compared to DM (Tang etal, 2011, 2014)."

reach
"Subsequent phosphorylation of p53 and translocation to the nucleus induces expression of caspase-3 and consequent apoptosis (XREF_FIG)."