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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CTNNB1 bound to AXIN activates CTNNB1. 2 / 2

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reach

"Specifically, phosphorylation of Axin by CKI and GSK3 increases Axin binding to beta-catenin, allowing the N-terminal region of beta-catenin to be a more efficient substrate of CK1alpha and GSK3."

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reach

"When the Wnt pathway is not engaged, CK1 and GSK3beta phosphorylate Axin bound beta-catenin to drive beta-catenin to the proteasome for disruption."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...