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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MDM2 bound to LATS2 activates TP53. 3 / 3

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"For example, LATS1 was found to regulate cytokinesis by inhibiting LIMK1; and LATS2 bound to Mdm2 to activate p53, serving as a novel checkpoint for the maintenance of proper chromosome number."

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"Lats2 binds Mdm2, inhibits its E3 ligase activity, and activates p53."

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"Lats2 binds to Mdm2 and upregulates p53, which in turn upregulates Lats2, thereby constituting a positive feedback loop for p53 activation in HEK293 cells XREF_BIBR."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

MDM2 bound to LATS2 activates TP53. 3 / 3

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