IndraLab

Statements

CTNNB1 decreases the amount of LEF1. 5 / 5
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"Tcf3 directly represses transcription of Lef1, which is stimulated by Wnt and beta-catenin activity."
22573616
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"Such N-terminally deleted beta-Catenin, lacking the first 86 and 89 amino acids (incrementN86 and incrementN89 beta-Catenin) was shown to cause increased LEF1 mediated transcription in vitro and increased proliferation, apoptosis and decreased migration in mouse intestinal epithelial cells XREF_BIBR, XREF_BIBR."
29872083
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"Knockdown of endogenous beta-catenin, however, decreased proliferation of oligodendrocytes by affecting expression of downstream lef1 and c-jun."
25178821
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"Knockdown of AK045490 Promoted beta-Catenin Nuclear Translocation and Up-Regulates the Expression of TCF1, LEF1 and Runx2."
31835596
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"Although WT beta-catenin did not show an apparent effect compared with an empty vector, the mutant beta catenin induced Axin2 and repressed the expression of both Id2 and Lef1 in DN3 thymocytes (XREF_FIG), highlighting a specific effect mediated by beta-catenin activation."
23103132