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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 activates ubiquitinated TP53. 4 / 4

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"In contrast, stress mediated modifications of MDM2 and p53 rapidly increase the non ubiquitinated p53 pool, exposing NLS I for efficient importin-alpha3 recognition and enhanced import."

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"It is inhibited by the RING-domain E3 ligase MDM2, which targets ubiquitinated p53 for degradation."

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"Recent studies suggest that Hdm2 mediated ubiquitination reduces Hdm2 and p53 affinity, which enable the mono-ubiquitinated p53 to be localized to the cytoplasm."

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"As expected, co-expression of MDM2 and p53 produced a ladder of ubiquitinated p53 (Ub-p53) products upon MG132 treatment."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

MDM2 activates ubiquitinated TP53. 4 / 4

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