IndraLab

Statements

Phosphorylated CTNNB1 leads to the ubiquitination of CTNNB1. 2 / 2
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"In the absence of Wnt signals, a dedicated complex of proteins that includes the tumor suppressor gene product APC, axin, and glycogen synthase kinase-3-beta (GSK3-beta) phosphorylates specific serine and threonine residues within the N-terminal region of beta-catenin, which leads to the ubiquitination of beta-catenin and its degradation by proteasomes."
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"The destruction complex regulates the sequential phosphorylation of beta-catenin, which leads to the polyubiquitination of beta-catenin by beta-TrCP and subsequent degradation by the proteasome pathway."
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