IndraLab

Statements

MAP2K1 binds PEBP1 and RAF1. 4 / 4
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"It has been shown that RKIP binds to Raf-1 and MEK1 at overlapping sites [14] ."
27033522
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"A yeast two-hybrid assay screen of a human T cell library was used to identify proteins that bound to Raf-1 kinase binding domains. xref The protein identified was designated RKIP, whose sequence was analogous to the human and monkey 23 kDa protein PEBP. xref Using anti-RKIP antibody, antisense RKIP and sense RKIP expression vectors, Yeung et al. discovered that RKIP could bind Raf-1 and MEK-1, and weakly bind to ERK-2, interfering with MEK phosphorylation and activation by Raf-1."
21984962
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"RKIP binds to Raf1 and MEK1, and prevents Raf1 in activating MEK [ xref ]."
| PMC
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"In the presence of RKIP, RAF1 cannot bind MEK1 ( xref )."
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