IndraLab

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Lipopolysaccharide activates JNK. 655 / 677
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"First, LPS activates not only ERK, but also JNK and p38 in Kupffer cells 30."
29317674
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"AMPK activation by AICAR or metformin attenuates either AngII- or lipopolysaccharide induced oxidative endothelium injury, and c-Jun N-terminal kinase (JNK) activation, via mitochondrion stabilization and increased mitochondrial biogenesis by PGC-1alpha [XREF_BIBR]."
22357101
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"Next, we further tested whether super-low-dose LPS mediated JNK activation may be responsible for the disruption of Smad4 and IRAK-M."
27824038
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"CO activated several stress kinase pathways, while LPS induced JNK activation was delayed and NF-kappaB signaling was impaired."
19956541
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"LPS stimulation of monocytes activates JNK with downstream activation of activating protein-1 (AP-1) and subsequent IL-1 b production."
| PMC
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"AP-1 promoter activity and p38 MAPK activation but not PKC, ERK and JNK activation induced by LPS were attenuated by oregonin."
16025135
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"As previously reported [23,24], we observed that LPS could activate the stress activated MAPKs, JNK and p38 as well as Raf-1 and ERK pathway in both 70Z/3 and spleen cells."
10988356
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"LPS caused activation of p38, JNK and ERK MAPKs in WT DCs."
21723158
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"LPS challenge activated SAPK and JNK activity and enhanced phagocytosis of AMs without altering phosphatase activity in these cells."
10638667
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"Moreover, LPS can activate JNK, a member of the MAPK family."
31486847
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"In addition, ghrelin treatment significantly inhibited LPS induced JNK activation and ROS production in BV-2 cells."
25309797
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"Finally, further study is warranted to define the relationship of PI3K and Syk to the Tec kinases in the pathway leading to LPS induced JNK activation in neutrophils, since PI3K and Syk reside upstream of JNK in this pathway [XREF_BIBR] and are upstream of the Tec kinases in other cell systems [XREF_BIBR, XREF_BIBR]."
19393603
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"Conclusion: CaSR is involved in myocardial injury induced by LPS in neonatal rats perhaps through the JNK pathway."
34816669
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"In contrast to Ngo epithelial cell contact, infection of macrophages by Yersinia enterocolitica suppresses the LPS mediated activation of JNK as well as p38 kinase activation."
9763607
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"Compound 3C also prevented LPS stimulated JNK activation and enhanced PGC-1alpha activation in microglia, which was attenuated by AMPK inhibition."
28803158
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"Xanthoangelol is a phytochemical that attenuates LPS induced c-Jun N-terminal kinase (JNK) phosphorlyation in macrophages, lowers macrophage infiltration into subcutaneous white adipose tissue, improves glucose tolerance, and increases UCP-1 expression in diet induced obesity (DIO) mice 55 but has not advanced to clinical trials in humans to date."
28641779
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"Dietary curcumin supplementation reduced these elevated levels of ROS/oxidative stress and p-JNK.Many studies have reported that LPS induces JNK activation which mediates neuroinflammatory responses and LPS has been extensively used in models studying neuroinflammation."
31827700
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"Our group recently reported that LPS activates JNK, p38, and NFkappaB in rat derived (L6) muscle cells XREF_BIBR."
23704966
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"Our data show that an apoE mimetic peptide, EP, attenuated LPS induced inflammatory responses by modulating JNK activation."
18803301
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"LPS induced p38 and ERK1/2 activation found in glial cultures was not detected in neuronal cultures, while LPS induced strong activation of JNK in glial but also in neuronal cultures."
23034047
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"The p38, ERK1/2 and JNK pathways were activated by LPS; however, the p38 and ERK1/2 pathways were blocked in AQP-1-overexpressing cells."
29731819
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"Activation of the Drosophila JNK and p38 mitogen activated protein kinases by bacterial lipopolysaccharide would support this theory."
11286695
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"We found that low-dose LPS upregulated JNK activation in the white matter without causing tissue damage."
22805152
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"LPS stimulation also resulted in almost normal activation of NF-jB and JNK in TRIF-deficient lung fibroblasts [38] ."
26579632
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"Specifically, LPS induced JNK p46 and NF-kappaB p65 phosphorylation states and IL-1beta and TNFalpha mRNAs in cGAMP treated WT primary mouse hepatocytes were significantly lower than their respective levels in control treated hepatocytes."
28743914
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"We showed that LPS activated ERK, P38, and JNK in mouse bone marrow stromal cells after 15min incubation."
26000311
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"However, aromadendrin selectively attenuated LPS induced JNK activation in a concentration dependent manner."
24265867
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"Interestingly, inflammatory stimulation with LPS activates JNK signalling resulting in phosphorylation of Ser63 [54]."
29432917
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"Mechanistically, Exendin-4 suppresses the LPS induced activation of the JNK and AP-1 pathway."
31685436
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"Kinase assay data showed that LPS injection induced JNK activity at 1h post-injection in both the maternal myometrium and the neonatal brain."
26183892
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"Pretreatment with NJ-1, NJ-3, or NJ-4 significantly inhibited the LPS induced activation of JNK and p38, but not ERK 1/2."
24795771
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"MAPK- (p38, ERK 1/2 and JNK) and NF-kappaB-mediated signaling pathways are differentially activated by LPS in human chorioamniotic cells (Jung et al., 2005; Shoji et al., 2007)."
19969371
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"GSH-OEt augmented p38 MAP kinase activation, but suppressed the JNK activation induced by LPS."
12847227
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"But JNK and phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway were only activated at 240min, but not at 120min, and wogonin inhibited LPS induced activation of JNK, AKT and PI3K (XREF_FIG)."
24901054
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"Our data show that LPS induces JNK activation and ROS production in BV-2 cells as in previous reports (XREF_FIG, XREF_FIG)."
25309797
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"Paroxetine blocks LPS induced JNK activation and attenuates baseline ERK1/2 activity in BV2 cells."
24618100
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"Activation of JNK and NF-kappaB Signaling by LPS in Peritoneal Macrophages from Middle Aged Mice."
24808968
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"SAPK and JNK was not activated by LPS."
10455914
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"Results showed that either palmitate or LPS quickly activated ERK, JNK and NFkappaB signaling."
30273577
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"Lipopolysaccharide (LPS) from different bacteria can be used to independently or mutually activate Jun N-terminal kinase (JNK)/AP1- or NF-kappaB-driven inflammatory pathways that lead to PTL."
26183892
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"Importantly, we observed that the direct induction of cell death and activation of JNK signaling by LPS on hepatocytes were rather minor, raising the possibility that the severe in vivo liver cell death caused by LPS was triggered by additional factors such as TNF-alpha that is known to be produced mainly by macrophages which was much enriched in the livers in sepsis (XREF_FIG)."
32457606
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"Interestingly, we found that venom prolonged LPS induced JNK activation in Raw264.7 macrophages."
24821138
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"However, CT selectively attenuated LPS induced JNK and c-Jun activation in a concentration dependent manner with concurrent significant attenuation of LPS induced pro inflammatory responses."
25009700
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"LPS caused down-regulation of I-kappaBalpha and activation of JNK, p38, and Erk MAPKs with distinct kinetics (XREF_FIG, right), similarly to previous reports."
18195069
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"Maximal activation of JNK by lipopolysaccharide requires the MAP3K TAK1."
12351623
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"Taken together, these data suggested that LPS promoted NF-kappaB and JNK signaling pathways by regulation of miR-127."
29451405
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"However, PMA and LPS induced SAPK and JNK activity was not affected by radicicol."
11562079
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"In neuronal cultures, LPS failed to induce activation of p38 or ERK1/2, but induced significant activation of JNK, 30 min after LPS treatment (level of activation detected was similar to that detected in glial cultures)."
23034047
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"Another study demonstrated that intervention in the LPS induced JNK signaling pathway restored PPAR-alpha expression in the heart and prevented LPS induced heart dysfunction (Drosatos etal, 2011)."
29976786
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"After LPS treatment for 30 min, the MAPK signaling pathway in LPS-induced RAW 264.7 cells was activated, as evidenced by significantly increased protein phosphorylation levels of p38, ERK1/2 and JNK."
| PMC
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"As we all know, LPS could activate JNK pathway and the ATF2 and c-Jun are regulated by JNK."
31829413
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"Silencing cANRIL alleviated LPS-induced inflammatory injuries and oxidative stress in HK-2 cells by blocking NF-κB and c-Jun N-terminal kinase (JNK)/p38 pathways via increasing miR-9 expression."
34604256
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"LPS treatment for 0.5 hours significantly activated JNK as measured by phospho and total JNK ratio, while after 2 and 24 hours LPS stimulation did not influence JNK phosphorylation."
22685622
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"Furthermore, JNK antisense oligonucleotides attenuated cellular levels of JNK protein and LPS induced JNK activation, but augmented IL-12 p40 protein production and mRNA expression."
12847227
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"Furthermore, expression of a catalytically inactive form of MKP-M in a mouse macrophage cell line increased the intensity and duration of JNK activation and TNF-alpha secretion after LPS stimulation, suggesting that MKP-M is at least partially responsible for the desensitization of LPS mediated JNK activation and cytokine secretion in macrophages."
11564882
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"As presented in XREF_FIG, heat stress alone or LPS combined with heat stress induced activation of p38, ERK and JNK."
28656249
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"Furthermore, we demonstrate that dexamethasone, which inhibits the production of cytokines, including TNF-alpha, significantly inhibits LPS induction of JNK and SAPK activity but not that of p38, ERK1 and ERK2, or MEK3, MEK4, or MEK6."
9343388
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"In addition, LPS stimulation activated the ERK, p38, and JNK MAPK pathways."
22414830
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"These results show that phosphorylation of JNK precedes cleavage of caspase-3 in HMEC treated with LPS and CHX."
19454725
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"The differences in the role of the Tec kinases in LPS induced JNK and p38 activation seen in this study may be related to the differences in conditions necessary for their activation."
19393603
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"Interestingly, a JNK inhibitor (SP600125) and another tyrosine kinase inhibitor (genistein) significantly inhibited STAT-1 phosphorylation, suggesting that the LPS activated JNK pathway and a tyrosine kinase pathway (especially Tyk2) may link to the STAT-1 pathway, which is involved in iNOS induction."
17108235
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"We found that LPS treatment induced a time dependent activation of JNK and p38 MAPKs which is differentially affected by FTY720, lowering the activation of the later while no significant effects were observed on the JNK pathway."
25953296
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"Furthermore, LSE was able to suppress LPS induced JNK, ERK, and p38 MAPK signal pathways."
27746869
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"The JNK kinase activity in response to adherent (P + Opa -) or invasive (P - Opa +) Ngo strains, which induce a variety of proinflammatory cytokines, was observed rapidly within 15 min after infection at a MOI of 50 and further increased within 90 min, whereas the nonpathogenic strain (P - Opa -) or LPS induced weak and no JNK activity, respectively."
9763607
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"As illustrated by Western blot analyses, MAPKs showed appreciable levels of phosphorylation (p-p38 MAPK, p-ERK1/2, p-SAPK and JNK) when cells were treated with LPS from 10 to 30 min (XREF_FIG)."
21774591
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"In human monocytes, activation of JNK by LPS proceeds through the MAPK kinase kinase MEKK-1 and, subsequently, the MAPK kinases MKK4 and/or MKK7."
17693927
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"LPS and D-GalN-treated Atg7Deltahep mice had increased JNK and caspase-8 activation resulting in enhanced Bid cleavage and subsequent increased mitochondrial cytochrome c release and caspase-3/7 activation as compared to wild type controls."
23775596
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"This suggests that GSK-3beta inhibition abrogates LPS induced activation of JNK due, at least partially, to a lack of activation of MLK3."
21194439
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"All three MAPK pathways i.e. p38, JNK and SAPK and ERK are activated by LPS in monocytes XREF_BIBR."
22506067
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"2-HF also prevented LPS induced activation of protein kinases p38MAPK and SAPK and JNK."
32800949
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"The reason why LPS failed to activate JNK and p38 MAPK may be because the duration of LPS exposure in our experiments (4 h) was too long."
24349401
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"These results suggest that MCPIP1 expression significantly inhibits LPS induced JNK activation but moderately affects ERK1/2, p38, and IKK activation."
21115689
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"In macrophage cell line, JNK could be activated by LPS and then regulated the TNF-alpha expression [10]."
29751034
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"In contrast, LPS did not significantly induce activation of JNK and p38 in CMT93 cells, p38 in T84 cells and MAPK and JNK in HT29 cells."
10623846
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"The results in Fig. 4A demonstrate that LPS, IL-1 and poly (I : C) activated the NF-kappaB, p38 and SAPK and JNK pathways to virtually the same extent (lanes 1-4)."
12062447
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"Because JNK has been shown to be required for IDO expression in CD11c+ dendritic cells following LPS stimulation, we tested the possibility that LPS induced JNK promotes expression of IDO in primary microglia."
19577630
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"In macrophages, lipopolysaccharide activates ERK, JNK and SAPK, and p38, and all are required for the translation of tumor necrosis factor (J Swantek, M Cobb, T Geppert, unpublished data)."
9069255
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"JNK inhibition suppresses death in neutrophils treated with LPS."
28611461
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"Previous studies showed that LPS-induced JNK activation can regulate Nur77 and then promote inflammation (Hongling Zhou et al., 2019)."
35370650
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"As discussed above, LPS/IFNγ-induced NO generation depends on TRPM2-mediated Ca signaling and activation of downstream PYK2 and MAPK p38 and JNK signaling pathways (Figure 2C)."
30914955
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"On the other hand, the Tpl2 gene deficiency has no effect on LPS mediated activation of JNKs and p38 or the activation of MEK and ERK by other inducers, such as mitogens."
12667451
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"Therefore, LPS, but not PMA, activates JNK in neutrophils in a dose dependent manner; consistent and substantial levels of JNK activation are detected only at higher LPS concentrations (10-25mug/ml)."
28611461
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"Activation of TAK1 by this important parasite signaling factor, together with LPS specific activation of JNK in our studies, suggests that JNK may function specifically in pathogen detection in An."
22111877
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"CWE blocked the LPS induced degradation of IkappaBalpha as well as the activation of JNK, p38 and ERK1/2."
23190501
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"These data indicated that EP attenuates LPS induced JNK activation via LRP1."
19586665
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"Meanwhile, LIPUS treatment effectively suppressed the LPS induced production of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, inducible nitric oxide synthase, and cyclooxygenase-2 in the microglial cells, in addition to inhibiting the LPS induced expressions of toll like receptor 4 and myeloid differentiation factor 88, as well as the LPS induced activation of c-Jun N-terminal kinase and nuclear factor kappa B. Furthermore, LIPUS significantly decreased the Bax and Bcl -2 ratio in the microglia following LPS treatment."
32248223
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"Knockdown of MLK4 enhanced LPS induced activation of JNK and ERK (XREF_FIG), while overexpression only reduced LPS induced ERK activation (XREF_FIG), suggesting that the effect of MLK4 on JNK and ERK activation is not all the same."
21602844
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"On the other hand, we observed sustained JNK activation in HMEC treated with LPS and CHX, and neither Erk1/2 nor AKT were activated."
19454725
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"CDK11 (p58) promotes rat astrocyte inflammatory response via activating p38 and JNK pathways induced by lipopolysaccharide."
22120654
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"Recently, several investigations [21-25] have suggested that especially c-Jun N-terminal kinase (JNK), one of the mitogen activated protein (MAP) kinases, plays a predominant role in lipopolysaccharid[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10462047
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"Lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), and thrombin preparations induced a rapid and lasting activation of JNKs in the cytoplasm."
15739188
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"In contrast, it is generally considered that JNK and p38 are activated by environmental stress, bacterial lipopolysaccharide, and inflammatory cytokines."
11781339
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"LPS activated MAPK, SAPK, and p38."
10329111
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"LPS stimulation of microglia activates all three MAPK pathways : p38, ERK1/2 and JNK [XREF_BIBR, XREF_BIBR]."
21194439
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"LPS induced a TLR4 dependent stimulation of NF-kappaB and the MAPKs p38, ERK1/2, and JNK."
21937604
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"We found that selonsertib pretreatment effectively prevented LPS induced activation of JNK and DRP1 and mitochondrial dysfunction in primary hepatic macrophages and macrophagic cell line and also suppressed the release of the proinflammatory cytokines TNF-alpha and IL-1alpha, which are known as major cytokines causing liver injury and inflammation [XREF_BIBR, XREF_BIBR]."
33413667
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"Manassantin B inhibited the production of IL-1beta and attenuated the phosphorylations of ERK1/2 and p38 MAPK, but not that of JNK, in RAW 264.7 cells treated with LPS."
22379572
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"These derivatives of G-Rh2 reduce LPS induced production of TNF-alpha, IL-6, and IL-1beta as well as the activities of p38 MAPK, JNK, and NF-kappaB, showing greater anti-inflammatory effects than that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29021688
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"In addition, IL-13 potentiated LPS induced activation of JNK, and the JNK inhibitor SP600125 suppressed the enhancement of COX-2 expression and attenuated microglial death."
16818793
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"Although MAPKs can transmit environmental stimuli into the nucleus to regulate the activity of cytokines or other inflammatory mediators such as TNF-alpha, IL-6 and NO, in this study, DMY treatment did not have a discernable effect on LPS induced activation of JNK and ERK proteins, as revealed by no changes in levels of phospho-JNK and phospho-ERK protein in macrophages."
24143247
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"The evolutionary divergence between mammalian and fish species is considerable, and we do not know if LPS can induce the IKK-NF-kappaB pathway and MAPK pathways (the ERK, JNK, and p38 pathways) in fish as in mammals."
16740160
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"As JNK activation is critical for LPS induced actin assembly in neutrophils [XREF_BIBR] and we show here that the Tec kinases regulate LPS induced JNK activation (XREF_FIG), we examined the role of the Tec kinases in LPS induced actin assembly in neutrophils."
19393603
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"For instance, bacterial lipopolysaccharide (LPS), a conserved component of the outer membrane of a gram-negative bacterium, has been shown to initiate JNK activation in monocyte/macrophage cells, and other types of cells [74,75,76]."
34502556
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"In particular, EA blocked LPS induced c-Jun N-terminal kinase (JNK) activation."
24971903
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"Overall, these results suggest that LPS/IFNγ-induced TRPM2-mediated Ca signaling initiates activation of PYK2 and downstream p38/JNK MAPK signaling pathways for activation of iNOS and subsequent NO generation (Figure 2C)."
30914955
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"In addition, activation of NF-kappaB as well as JNK and p38 signaling induced by LPS was not modulated by telmisartan."
31330445
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"Furthermore, phosphorylated P38 MAPK and ERK decreased dramatically at 40min, while JNK signaling was still activated by LPS."
27514378
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"TLR4 signaling by LPS leads JNK activation through MyD88 dependent pathway, resulting in AIMP1 phosphorylation."
20510162
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"However, LPS stimulation of MyD88 null macrophages activates NFkappaB and JNK, although this activation is delayed when compared with that of wild-type cells [101]."
11937262
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"Peng et al. [XREF_BIBR] showed that LPS increases JNK activation in cultured cardiomyocytes."
22685622
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"Besides, CCL5 silence inhibited LPS induced activations of JNK and NF-kappaB pathways."
29922423
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"Three types of MAP kinases (ERK1/2, p38, and JNK) can be activated by LPS in cardiomyocytes XREF_BIBR, XREF_BIBR."
22761733
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"We recently reported that super-low-dose LPS selectively activates GSK3 and JNK while suppressing Akt and ERK."
25610440
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"PMA induced reactive oxygen species or bacterial endotoxins (LPS) also stimulate JNK or P38 kinase to enhance NF-kappaB-mediated MUC5AC expression."
33510050
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"However LPS induced activation of JNK and p38as well as NF-kB in cells with combined SREC-I and TLR4 expression (XREF_FIG, lanes 3-6) was blocked by many of the inhibitors (XREF_FIG)."
25836976
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"These findings indicated that MSCs can support T-cell functions by regulating MAPK-ERK/JNK signaling.The lipopolysaccharide (LPS)-induced acute lung injury model demonstrates a severe immune response characterized by diffuse interstitial and alveolar edema, inflammatory cell infiltration, and the release of proinflammatory factors, which are similar to the symptoms of COVID-19 caused by the rapid replication of SARS-CoV-2 in the lungs.30,31 We next investigated the effect of MSCs on lung injury repair."
34702946
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"LPS induced p38MAPK activation followed pro nerve growth factor (proNGF) production was inhibited by TTX, whereas LPS induced JNK activation was not."
24038428
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"LPS caused a transient activation of JNK which was followed by increased COX-2 expression."
16644485
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"The data in Figure 3 demonstrated that LPS priming induced the activation of c-Jun and MAPKs including ERK, c-Jun N-terminal kinase (JNK) and p38 MAPK in differentiated THP-1 cells."
31191313
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"Cycloheximide at 0,05-0,1 mug/ml concentrations increased LPS induced JNK activity."
16504051
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"Since paroxetine inhibited LPS induced JNK activation as well as baseline ERK1/2 activity, we then asked whether the inhibitory effect of paroxetine on microglial activation is via JNK and (or) ERK pathways."
24618100
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"Having determined that LPS was able to promote NF-kappaB and JNK signaling pathways by regulating miR-127, we further studied whether APS exerted its relieving effects on LPS induced inflammation injury through inhibiting these ways."
29451405
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"These results suggest that in RBA-1 cells, LPS activates a TLR4/c-Src/Pyk2/PDGFR/PI3K/Akt/p38 MAPK and JNK1/2 pathway, which in turn triggers activator protein 1 (AP-1) activation and ultimately induces MMP-9 expression and cell migration."
31905967
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"PI3K p110beta siRNA inhibited JNK activation, but not p38 MAPK or ERK activation, stimulated by LPS, while PI3K p110alpha siRNA did not affect LPS induced JNK, p38 MAPK, or ERK activation in both cell types."
19380768
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"Data reported in this paper demonstrated that LPS stimulation activates both p38 MAPK and JNK."
22685622
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"These results demonstrate that TGF-beta1 inhibits LPS stimulated JNK activity in mouse macrophages."
10462047
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"We conclude that macrophages from aged mice exhibited suppressed proinflammatory cytokine production, which correlated with diminished total levels and LPS stimulated activation of p38 and JNK."
14634059
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"Compound 4 was able to dramatically inhibit LPS induced activation of JNK1/2 and ERK1/2 and remarkably disrupted the TLR4 dimerization in LPS induced RAW264.7 macrophages."
27666387
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"LPS stimulation activates two main pathways, MAPK (ERK, JNK, and p38) and NFkappaB."
22308309
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"Studies have shown the major role of MKK7 in TNFα and LPS-activated JNK signaling (Tournier et al., 2001; Caliz et al., 2021)."
36340039
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"LPS, a microbial constituent with potent DC activating properties, which signals via the recently described Toll-4 receptor, also selectively induces p38 (Ardeshna et al., 2000; Rescigno et al., 1998)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12617997
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"LPS treatment induces JNK activation in human neutrophils."
28611461
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"In addition, salicortin inhibited the LPS induced activation of JNK, but not ERK or p38 MAPK."
24286322
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"LPS activated TRL4 activates the NFkappaB pathway and all three MAPK pathways (ERK, JNK and SAPK, and p38)."
30158835
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"This LPS mediated JNK activation is consistent with one previous report, but not with others XREF_BIBR, XREF_BIBR."
28611461
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"However, in the present study JNK pathway was not activated by LPS, and selective inhibition of JNK showed no effect on LPS induced coagulation."
22461999
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"Pretreatment of cells with different concentrations of IL-13 significantly abolished LPS induced JNK."
23554645
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"We like others, found that CO delayed LPS induced JNK activation."
19956541
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"In contrast, LPS stimulated JNK function correlates with MKK4 function in microglia."
18713996
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"Therefore, we propose that the improvement of septic hypotension by octyl caffeate might not merely be due to its inhibition of iNOS dependent NO generation, but also to its antioxidant scavenging act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12694879
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"As expected, LPS treatment increased the ratio P-JNK/JNK (153.7 ± 60.5%; p < 0.05 compared with control animals; Figure 6C and Supplementary Figures S5, S6), whereas metformin treatment abolished this effect (89.0 ± 33.7% of control values; p < 0.05 compared with the LPS group)."
30519161
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"The clear discrepancy of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11360925
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"The induction of phosphorylation of both JNK and p38 in BV-2 cells treated with LPS for 3 h was suppressed dose-dependently by the pretreatment of the cells with Dex."
21615929
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"In contrast, however, macrophages isolated from either XLA patients [XREF_BIBR] or Btk deficient mice [XREF_BIBR] show normal levels of JNK phosphorylation after LPS stimulation, suggesting that either other, non Btk, Tec kinases regulate LPS induced JNK activation in macrophages or that LPS induced JNK activation in macrophages is independent of the Tec kinases."
19393603
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"LPS treatment triggers inflammatory responses such as activation of IKK and NF-kappa; B and JNK and the activation of NF-kappa; B dependent genes in both quiescent and activated HSCs 58."
20665376
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"Treatment with SB220025 increased also LPS induced c-Jun N-terminal kinase (JNK) activity."
16504051
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"LPS activated C-Jun N-terminal kinase, p38MAPK, and extracellular signal regulated kinase in wt cells, but the levels were much higher in p60-/-, p80-/-, and p60-/- p80-/- cells."
12695514
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"Overall our data suggests that LPS induces JNK activation only in non suspended neutrophils, which proceeds through Syk- and PI3K dependent pathways, and that JNK activation is important for LPS induced MCP-1 expression but not for TNF-alpha or IL-8 expression."
14699155
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"One function of the protein is to interact with IL1RI, TLR2 and TLR4 after lipopolysaccharide (LPS) activation, thereby modulating the NF-kappaB and JNK signaling pathways and consequently inflammatory responses to infection XREF_BIBR."
27484700
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"LPS stimulation also resulted in almost normal activation of NF-κB and JNK in TRIF-deficient lung fibroblasts [38]."
26579632
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"Rather, MLK4 appears to be able to inhibit lipopolysaccharide (LPS)-induced activation of the JNK or ERK pathways, but does not have effect on LPS induced p38 or NF-kappaB activation."
21602844
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"In addition, only a few studies have investigated whether TLR4 mediates LPS induced myocardial dysfunction by modulating the JNK signaling pathway."
33760172
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"We show here that both Tec and Btk are activated in human neutrophils stimulated with LPS, that Tec kinases are upstream in the LPS induced pathway regulating JNK, but not p38, activity, and that actin assembly and cytokine production in LPS stimulated human neutrophils is dependent on activation of the Tec kinases."
19393603
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"These findings indicated that MSCs can support T-cell functions by regulating MAPK-ERK/ JNK signaling.The lipopolysaccharide (LPS)-induced acute lung injury model demonstrates a severe immune response characterized by diffuse interstitial and alveolar edema, inflammatory cell infiltration, and the release of proinflammatory factors, which are similar to the symptoms of COVID-19 caused by the rapid replication of SARS-CoV-2 in the lungs."
34702946
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"Many studies have shown that LPS activates ERK1/2, JNK, and p38 in macrophages XREF_BIBR and that many of the downstream targets of MAPK pathways are transcription factors, which regulate various genes encoding inflammatory mediators XREF_BIBR; XREF_BIBR; XREF_BIBR."
24265867
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"In Raw 264.7 cells treated with MNSFbeta small interfering RNA (siRNA) lipopolysaccharide (LPS)-induced ERK1/2 activation was enhanced and LPS induced JNK and p38 activation was unaffected."
16621790
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"The clear difference of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11460313
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"Regarding the TLR4 mediated NF-kappaB and ERK signaling, overexpression of ROCK1 increased the activity (phosphorylation form) of ERK1/2, JNK, and p38 which was firstly induced by LPS (XREF_FIG, XREF_SUPPLEMENTARY)."
29804125
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"It is known that LPS activates the NF-kappaB pathway and all three MAPK pathways (ERK, JNK and SAPK, and p38alpha), leading to a wide range of cellular responses, including cell differentiation, survival or apoptosis, and inflammatory responses [XREF_BIBR]."
26114754
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"Evaluation of protein expression in lung tissues showed that the increased expression of nuclear NF‑κB p65 and p‑c‑Jun N‑terminal kinase (JNK) induced by LPS were suppressed in the LPS + PHC group and the expression of TIPE2 was increased."
34468006
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"Propofol augmented the activation of JNK and p38 MAPKs induced by LPS and the synergistic activation of glial cells by propofol was prevented by pretreatment of JNK and p38 inhibitors."
23899524
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"Incubation of cells with both LPS and LPC did not counteract LPS induced activation of JNK and p38 (XREF_FIG)."
24312681
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"ERK activation was not induced by the chemicals tested, while SAPK and JNK and p38 MAPKs were strongly modulated by the sensitizers and LPS, with an increased activation at 1h post-treatment that fell over time but remained above basal values at 6h."
29477863
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"LPS has been shown to induce JNK and p38 activation [XREF_BIBR]."
23247009
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"In mice, LPS/D-galactosamine (D-GalN)-induced liver damage resulted in activation of JNK1/2."
28635648
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"However, that the action of the antiviral factors in supernatants of LPS activated cells is independent of both p38 MAPK and JNK, since MDM treated with LPS supernatants were resistant to ADA infection, despite being infected and cultured in the presence of the kinase inhibitors (XREF_FIG)."
21904615
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"ERK, JNK, and p38 MAP kinases are activated by LPS in microglia and inhibition of a respective kinase with pharmacological inhibitors : CEP11004 or CEP-1347 reduced cytokine production in LPS stimulated human and murine microglia cultures [XREF_BIBR, XREF_BIBR] or exposed to neurotoxic peptide Abeta1-40 [XREF_BIBR]."
22806180
reach
"In addition, LPS significantly increased the JNK activity in alveolar epithelial cells; Ang-(1-7) concentration-dependently inhibited LPS induced JNK activity, which was abolished by A779 and Mas shRNA."
26641856
reach
"These results suggest that LPS induces apoptosis by engaging PI3K and JNK signaling pathways through tyrosine kinase in TBBEC."
19454725
reach
"We have previously shown that JNK [XREF_BIBR] and p38 [XREF_BIBR] are activated by LPS in human neutrophils."
19393603
reach
"In agreement with these reports, in our studies we found that LPS treatment of human macrophages induced the early activation of NF-kappaB, p38, JNK and ERK."
23911403
reach
"LPS activates nuclear factor kappa B (NF-kappaB), JNK, and p38 through TLR4 to induce the expression of IL-12, IL-6, and TNF-alpha in DCs XREF_BIBR."
26030277
reach
"Furthermore, inhibition of GSK-3beta by lithium has no effect on LPS induced JNK activation in human monocytic cells [XREF_BIBR]."
21194439
reach
"We found that EP decreased JNK activation and thereby suppressed the LPS induced JNK activation."
18803301
reach
"Our data shown in XREF_FIG revealed that LPS treatment significantly enhanced activation (phosphorylation) of the stress signaling molecule JNK and p38 without affecting pan protein expression of JNK and p38."
22902401
reach
"Moreover, translational studies with human choriodecidua demonstrated that ASK1 was required for LPS-induced activation of JNK and p38 and pro-inflammatory cytokine production."
32024889
reach
"LPS induces transient activation of JNK followed by NF-kappaB activation, which regulates cellular survival."
19454725
reach
"P38, JNK, ERK and NF-kappaB subunit p65 inhibitors could significantly inhibit the secretion of IL-1beta, TNF-alpha and HMGB1 induced by LPS."
32862374
reach
"LPS induced phosphorylation of p38 kinase was maximal at 2 h and markedly diminished at 8 h : LPS activation of ERK1/2 and JNK 1/2 peaked at 30 min and persisted over the 4-h time period."
14644621
reach
"Low levels of LPS (e.g., 100ng/ml) do not activate JNK unless the cells are primed with cytokines XREF_BIBR - XREF_BIBR; however, whether LPS at higher concentrations activates JNK or regulates NETosis induced by LPS containing bacteria is unknown."
28611461
reach
"Our research shows that M2 cells treated with PI3K inhibitor LY294002 inhibits LPS induced activation of JNK, suggesting PI3K is a positive regulator of MAPKs."
26158762
reach
"The authors noted an LPS triggered activation of the JNK pathway, eventually leading to an inhibition of osteoblast differentiation and programmed cell death."
26063979
reach
"CO activated p38 MAPK, ERK1/2 and Akt and caused an early and transitory delay in LPS induced JNK activation."
19956541
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"[XREF_BIBR XREF_BIBR] In addition, JNK is activated by LPS stimulation and has been postulated to play an important role in controlling iNOS gene expression."
27867272
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"However, isorhamnetin failed to prevent LPS induced activation of either c-Jun N-terminal kinase (JNK) or p38 pathways."
26783837
reach
"Also, CPZ, LPS or LTA did not activate JNK by itself up to 4 h in either of the groups (XREF_FIG)."
23238562
reach
"In the present study, we found that ACE2 overexpression significantly blocked LPS–induced activation of the p38 and JNK pathways, which was strikingly prevented by administration of the Mas receptor blocker."
25644821
reach
"Moreover, LPS pretreatment enhanced the activation of NF-kappaB, ERK and JNK by MDP in hepatocytes."
22218461
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"The amplified inflammatory cytokines were reduced in the presence of P38 inhibitor or JNK inhibitor (Supplementary Fig. 1b,c), indicating that P38 and JNK might also be essential for RIPK1- and RIPK3-mediated inflammatory signaling pathway.To further confirm the roles of P38 and JNK in RIPK1- and RIPK3-induced inflammatory signaling pathway, we analyzed the activation of P38 and JNK and found that LPS plus zVAD induced more P38 and JNK activation compared with those induced by LPS alone (Fig. 1a)."
30442927
reach
"As shown in XREF_FIG, LPS treatment significantly increased the level of the phosphorylated form of ERK, JNK, and p38."
28989571
reach
"COX-2 expression and signaling molecules (JNK, p38MAPK and c-jun) activated by LPS were assessed."
21911040
reach
"LPS promotes epithelial-mesenchymal transition and activation of TLR4 and JNK signaling."
25053598
reach
"In addition, we showed that TGF-beta1 blocked LPS stimulated JNK activity in the cells."
10462047
reach
"LPS did not activate JNK1/2 and p38 MAP kinases in NB-1 cells until 60 min whereas LPS activated them at 30 min in U937 cells."
17156435
reach
"Although IGF-1 transgene itself did not affect the activation and phosphorylation status in these stress signaling molecules, it ablated LPS induced activation of JNK and p38 without altering the profile of ERK phosphorylation."
18948844
reach
"Indeed, both EPA and DHA were shown to impair LPS-induced JNK activation and TNF-α and IL-6 secretion by RAW 264.7 cells and 3T3-L1 adipocytes in vitro through the activation of GPR120 [171]."
30116154
reach
"Meanwhile, p38 and JNK and NF-kappaB pathways induced by LPS were repressed by gastrodin."
31769187
reach
"Moreover, TAN treatment attenuated LPS induced activation of JNK and NF-kappaB pathways in HaCaT cells."
30632205
reach
"Whereas JNK is activated by LPS [XREF_BIBR] and TNF-alpha [XREF_BIBR] only in non suspended adherent cells, likely due to the requirement for beta 2 integrin ligation [XREF_BIBR], LPS- [XREF_BIBR] and TNF-alpha-induced [XREF_BIBR] p38 activation is present in suspended neutrophils."
19393603
reach
"Furthermore, LPS induced JNK and ERK activation, and inhibition of JNK as well as ERK attenuated AP-1 activation, and AP-1-dependent CXCR6 expression."
16870145
reach
"Lipopolysaccharide (LPS) activates ERK1/2, p38 and JNK and SAPKs and all are required for the biosynthesis of tumor necrosis factor-alpha (TNF-alpha) (Geppert et al., 1994; Han et al., 1994; Lee et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10354710
reach
"Kudzu leaf extract decreased LPS induced activation of c-Jun N-terminal kinase (JNK) and TANK binding kinase 1 (TBK1) with no effects on nuclear factor-kappaB and activator protein 1 transcriptional activity."
29786649
reach
"These results suggest that LPS activation of JNK in monocyte and macrophage cells is a CD14- and protein tyrosine phosphorylation dependent event that may mediate the early activation of AP-1 in regulating LPS triggered gene induction."
8610116
reach
"Glucocorticoids also inhibit LPS stimulation of JNK and SAPK; overexpression of JNK and SAPK overcomes the TNF-alpha translational block (Swantek et al., 1997)."
10354710
reach
"It is well-known that LPS activates ERK, p38 and JNK MAPkinases."
17916230
reach
"Chang et al. reported that beta-glucogallin isolated from amla could inhibit LPS-induced oxidative stress by preventing activation of JNK and p38 in murine macrophages (Chang et al. 2013)."
36349282
reach
"LPS stimulation was shown to activate the JNK signaling pathway in addition to NF-kappaB via the TLR4 signaling pathway."
21152039
reach
"LPS treatment significantly increased phosphorylation levels ERK 1/2, p38 and JNK 1/2 in RAW264.7 macrophages (P < 0.05; XREF_FIG)."
28677786
reach
"In addition, the LPS induced up-regulations of nuclear p65, p38, p-p38, p-ERK1/2, JNK and p-JNK proteins in RAW 264.7 cells significantly decreased by PMF, and expressions of cytosolic p65 and IkappaB were obviously up-regulated after treatment with PMF."
26263166
reach
"In primary microglia, nicotine has been shown to inhibit LPS induced activation of JNK and p38 14."
28904864
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"22 In addition to ERK1/2, we showed that Tpl2 engaged the signaling kinases JNK and p38 in beta-cells, as reported in microglial cells treated with LPS."
26794660
reach
"In addition, we showed that spleen tyrosine kinase (Syk) and phosphatidylinositol 3-kinase (PI3K) were upstream in the pathway leading to LPS induced JNK activation in neutrophils [XREF_BIBR]."
19393603
reach
"Thus, we confirmed that the JNK signal transduction pathway was activated in NCI-H292 cells by PLA, LPS, or PLA+LPS."
28116315
reach
"Several studies have demonstrated that LPS triggers ROS generation/oxidative stress and activates the stress kinase JNK, subsequently mediating the pathogenesis of various neurodegenerative disorders [33, 34]."
31827700
reach
"Whereas GalN/LPS treatment-induced hepatic activation of NF-kappaB and JNK in wild-type and SphK2 -/- mice, these signaling pathways were reduced in SphK1 -/- mice."
33566377
reach
"LPS is known to activate JNK1/2 and p38 MAP kinases through TAK1, a downstream molecule of TLR4 mediated signaling pathway [XREF_BIBR]."
17156435
reach
"Moreover, MCL inhibited LPS induced the activition of c-Jun N-terminal kinase (JNK), p38 MAPK kinase, and extracellular signal regulated kinases 1/2 (ERK1/2)."
29040306
reach
"Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK, p38 mitogen-activated protein kinases (MAPK), and slightly inhibited cyclooxygenase (COX-2) in BV-2 cells but decreased p38 MAPK and COX-2 expressions in the liver of LPS-treated rats."
21721151
reach
"SAPK and JNK was not activated by LPS."
10455914
reach
"Both NF-kappaB and JNK pathways were activated by LPS, while were blocked in Hsp27 overexpressing cells."
28448995
reach
"Emodin also suppressed the LPS stimulated activation of STATs, JNK, and p38 MAPK."
27538959
reach
"The clear discrepancy of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11360925
reach
"Another study using a vasodilator cilostazol has shown the signi?cant inhibition of lipopolysaccharide mediated activation of JNK which lead to the reduction of MMP-9 levels and downregulation of MMP-9 by JNK inhibition resulted in theinhibition of macrophage uptake [XREF_BIBR]."
25009774
reach
"These observations suggest that LPS induces specific activation of the JNK signaling pathway in neuronal cells."
23034047
reach
"In addition, miR-146a-5p mimic blocked LPS-induced TRAF6 upregulation, as well as LPS-induced c-Jun N-terminal kinase (JNK) activation and chemokine CCL2 expression in astrocytes."
25957028
reach
"There are several signaling pathways such as NF-kappaB and MAPKs, including extracellular signal regulated kinase (ERK), p38, and c-Jun N-terminal kinases (JNK), that are activated by LPS stimulation."
29804558
reach
"Pre- and post-treatment with DET (10 mg/kg) inhibited the activation of JNK1/2 induced by LPS/D-GalN in ICR mice."
35408483
reach
"Although LPS induced JNK activation was unaltered in CD36KO macrophages, expression of the proinflammatory genes il6 and tnfa were markedly reduced."
21378177
reach
"By interacting with the toll like 4 receptor (TLR4), LPS activates the NF-kappaB, p38MAPK, or JNK signaling pathways, resulting in subsequent inflammatory cell damage."
33188619
reach
"To test whether PLA or LPS could activate the JNK signaling pathway in NCI-H292 cells, protein expression levels of p-JNK and JNK were measured by western blotting."
28116315
reach
"In our study, we observed that both Pam3 and LPS activate ERK1/2, p38, and JNK to a similar extent, despite the differential effect of the applied ligands on pro- and anti-inflammatory cytokine levels."
29096690
reach
"Youssef et al. showed that LPS can quickly activate p38, ERK, and JNK signaling in microglia [XREF_BIBR]."
33727946
trips
"G-CSF did not affect LPS-induced activation of ERK, p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules."
14736711
reach
"In BV2 and primary microglia cell lines, the knockdown of Parkin was found to increase LPS-induced microglial activation by elevating the activity of NF-κB and JNK, which protected neurons from zVAD-mediated necroptosis (Mouton-Liger et al., 2018; Dionisio et al., 2019)."
34336822
reach
"However, since LPS still activates NF-kappaB and JNK and p38 in MyD88 deficient macrophages, the existence of a MyD88 independent pathway (s) that leads to NF-kappaB and JNK and p38 activation in TLR4[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12433365
reach
"Moreover both forms of LPS activated NF-kappaB, p38 MAPK and ERK pathways, but not the SAPK and JNK pathway."
23554896
reach
"To examine the direct effect of LPS on the activation of ERK1/2, p38 and JNK, H9c2 cells were treated with various concentrations of LPS (0.1-10mug/ml) for 15min to assess activation."
28878808
reach
"Some studies have reported that ApoA-I can inhibit the LPS induced activation of JNK in mouse macrophage RAW264.7 cells [XREF_BIBR] and can inhibit the production of IFN-gamma and IL-6 in mouse serum [XREF_BIBR]."
29245934
reach
"However, LPS activates NF-kappaB, and JNK and p38 in MyD88 -/- macrophages, albeit with delayed kinetics."
12591910
reach
"The result was unexpected because MyD88 deficient mice are resistant to the LPS induced activation of JNK XREF_BIBR."
20824098
reach
"As shown in XREF_FIG, prolonged incubation of monocytes with super-low dose LPS for 5 days led to the activation of JNK, and addition of TUDCA ablated the JNK activation mediated by LPS."
26690561
reach
"LPS induced JNK, ERK1/2, and Akt phosphorylation was not arrested by acetylcorynoline treatment."
23472193
reach
"In the present study, liver tissues were harvested from mice pretreated for 30 min with saline, LPS or LTA followed by saline or CPZ up to 4 h. Immunoblotting studies indicated that LPS moderately activated JNK (as evidenced by phosphorylation of JNK) up to 1 h only (XREF_FIG)."
23238562
reach
"PRDX6 overexpression inhibited LPS induced macrophage, T cells and neutrophils infiltration as well as JNK and p38 MAP kinase activation."
28881633
reach
"It appeared that the LPS activation of both JNK and NF-kappaB signaling pathways was modulated by lycopene."
22648619
reach
"NJ-1, NJ-3, and NJ-4 inhibited LPS induced activation of c-jun NH2-terminal kinase (JNK) and p38 but did not affect activation of extracellular signal regulated kinase (ERK) or NF- kappa B. On the other hand, NJ-6 inhibited activation of MAPKs and NF- kappa B."
24795771
reach
"MAPK signaling was targeted because LPS stimulation activates p38, ERK, and JNK."
32707636
reach
"LPS signalling is known to be mediated via all three MAPK : JNK, p38, and ERK, and results in IL-1b expression [XREF_BIBR]."
24083466
reach
"The inhibitory effect of p38 MAPK appears to be more complex and may be due to the ability of p38 MAPK to inhibit LPS induced JNK activation [22]."
12694879
reach
"In addition, catalase enzyme alleviated LPS induced activation of JNK and p38 signaling."
22902401
reach
"Interestingly, knockdown of LRRC33 also induced the duration of LPS mediated JNK and p38 activation in DCs."
23545260
reach
"The results showed that LPS (1 mug/mL) induced marked activation of ERK1/2, p38 and JNK1/2 in a time dependent manner (XREF_FIG A)."
26861286
reach
"In summary, AKF-PD can protect against ALF caused by APAP or LPS/D-Gal, in part, via regulating MKK4/JNK pathway."
37224750
reach
"As shown in XREF_FIG, phosphorylation of ERK, JNK, and p38 MAPKs increased significantly when the cells were treated with LPS (1 mug/mL) for 1 h. Phosphorylation decreased in a dose dependent manner by the treatment with CSP32 (10-100 mug/mL)."
28493903
reach
"In addition, LPS significantly increased the JNK activity in alveolar epithelial cells; Ang-(1-7) concentration-dependently inhibited LPS-induced JNK activity, which was abolished by A779 and Mas shRNA."
26641856
reach
"Extracellular histone H3 facilitated ferroptosis of human umbilical vein endothelial cells (HUVECs) induced by LPS through activating the ROS/c-Jun N-terminal kinase (JNK) pathway."
36705411
reach
"Furthermore, studies with several cell culture systems indicate that lipopolysaccharide (LPS) can activate P38 MAPK, ERK, and JNK signaling [XREF_BIBR]."
27514378
reach
"In the present study, we found that overexpression of miR-30b promoted the activation of JNK signaling pathway induced by LPS in HK-2 cells."
29635893
reach
"LPS activates hepatic JNK."
15312234
reach
"LPS induced activation of JNK and p38 was not affected by azithromycin treatment."
24534490
reach
"bPN also inhibited the LPS stimulated activation of JNK and ERK signaling, and inhibited the LPS stimulated degradation of I (K) B in the RAW264.7 cells."
21703595
reach
"Our study showed that LPS increased the activation of p38, JNK, and Erk in BV2 cells."
25088370
reach
"d-GalN/LPS treatment resulted in a marked inflammatory cytokine release and stimulated the activation of signal transducer and activator of transcription (STAT) 3, c-Jun N-terminal kinases (JNK) and extracellular signal-regulated kinase (ERK) signaling comparably in the hepatic compartment of Bcl-3 Hep and WT mice."
35641486
reach
"In the present study, we further found that melittin and bee venom significantly reduced inflammatory stimuli (LPS and SNP)-induced activation of JNK signal, and the JNK signal specific inhibitor SP600215 suppressed the inhibitory effect of melittin and bee venom on the NF-kappaB activation, and inflammatory reaction in Raw 264.7 macrophages and synoviocytes obtained from rheumatoid arthritis patients."
18507870
reach
"Therefore, we focused our present study on the regulatory action of TGF-beta1 on LPS stimulated JNK activity in murine macrophages."
10462047
reach
"Thus, the present data demonstrate that TVE produces anti-inflammatory effects in LPS-stimulated RAW264.7 cells by inhibiting the JNK/NF-kB signaling pathway."
35159514
reach
"The clear difference of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11360925
eidos
"Specifically , LPS activated p38 , JNK , and ERK1 / 2 pathways while flagellin activated the p38 and ERK1 / 2 pathways , despite both PAMPs inducing similar levels of inflammatory cytokines IL-6 , IL-1beta , TNF-alpha , and CXCL-1 ."
33173008
reach
"Triptolide blocked MKP-1 induction in LPS stimulated macrophages, prolonged p38 and JNK activation, but had little effect on ERK activity, illustrating the critical role of MKP-1 in the deactivation of p38 and JNK in these cells."
21566680
reach
"XREF_BIBR JNK and p38 MAPK are predominantly activated by inflammatory cytokines (TNFalpha and IL1beta) and bacterial LPS."
29317816
reach
"LPS induced cleavage (activation) of caspase-3, an indicator of apoptotic change, and increased protein expression of proapoptotic molecules, Bax and Bim, and activation of c-Jun NH 2 -terminal kinase (JNK and SAPK) in the liver and spleen were attenuated by both simvastatin and FTI-277."
20034462
reach
"We show here that exposure to LPS activates JNK in non suspended neutrophils and that LPS induced MCP-1 expression, but not tumor necrosis factor-alpha (TNF-alpha) or interleukin-8 (IL-8), is dependent on JNK activation."
14699155
reach
"Melittin inhibited LPS and SNP induced activation of JNK in RAW 264.7 cells."
18507870
eidos
"Moreover , LPS can activate JNK , a member of the MAPK family ."
31486847
eidos
"LPS activates ERK1 / 2 , JNK , and p38 MAPK , which ultimately control the activity of transcription factors regulating the expression of inflammation modulators , such as induced NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) , TNF-alpha , IL-1alpha , IL-1beta , and IL-6 [ 44 ] ."
| PMC
reach
"The toxin GalN converted LPS induced JNK signaling from a transient to prolonged activation."
16979778
reach
"In addition, phosphorylated IkappaBalpha and JNK were similar to PBMCs of AOSD patients and HCs treated with LPS."
27537874
reach
"Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide induced destabilization of SIRT1 by inactivating JNK."
27771463
reach
"LPS is commonly used to stimulate immune responses in insects, and activates the JNK pathway of the innate immune system."
19014614
reach
"These results further confirmed that berberine protected the HUVECs against LPS induced injury by blocking the LPS activated JNK signaling pathway."
27478481
reach
"In primary microglia, an apoE-mimetic peptide inhibits LPS induced JNK activation through interactions with the LDL receptor family members [XREF_BIBR, XREF_BIBR]."
26438529
reach
"In macrophages and other types of cells, LPS activates three subclasses of MAPKs: extracellular signal-regulated kinase (ERK), c-Jun-terminal kinase (JNK) and p38."
21160452
reach
"Similar results are described by Kim et al. [122] for 6,6bieckol, which can reduce, depending on the dose, the expression of iNOS, COX-2, and pro-inflammatory cytokines in LPS-stimulated RAW 264.7 cells and BV2 microglial culture cells through the inhibition of the IκB-α/NF-kB and JNK pathways/ p38 MAPK/Akt, in connection with which this PTs can become the basis of a therapeutic agent for the treatment of neuroinflammatory diseases in the future [122] ."
35447916
reach
"We found that LPS triggered transient activation of three MAP kinase subfamilies, ERK, JNK, and p38, in both immortalized and primary murine alveolar macrophages."
15590669
reach
"In macrophages, LPS stimulates the simultaneous activation of all three classes of MAP kinases, ERK, c-jun N-terminal kinase, and p38, albeit with differential activation kinetics."
10586030
reach
"In this research, E. coli LPS stimulated the vitalizations of the three MAPKs of ERK, JNK, and p38 in the RAW264.7 cells."
27488844
reach
"Thus, JNK inhibition suppresses death of neutrophils even when the cells were treated with high concentrations of LPS (25mug/ml)."
28611461
reach
"Subsequent mechanistic studies revealed that ar-turmerone inhibited LPS induced JNK, p38 MAPK and NF-kappaB activation."
22766494
reach
"A time course of the activation and phosphorylation of ERK, JNK and p38 in microglia treated with LPS in the presence and absence of the Tpl2KI is shown in XREF_FIG."
24188160
reach
"QG significantly attenuated LPS induced activation of JNK and ERK in concentration dependent manners with a negligible effect on p38."
27257013
reach
"LPS regulates tumor cells mainly through binding with toll like receptor 4 (TLR4), and then activates the PKC, MAPKs, JNK and ERK1/2 signaling pathways, thereby affecting the activity of the transcription factors AP-1 and NF-kappaB XREF_BIBR."
33456361
reach
"LPS treatment induced activation of NF-kappaB and JNK and p38 [XREF_BIBR], it was possible that a low concentration of GTE might also inhibited JNK activity upon LPS treatment in macrophages."
28400856
reach
"Our data showed that C 60 significantly inhibited p38 MAPK, ERK1/2, and JNK activation induced by LPS."
26058514
reach
"After being pretreated with octyl caffeate (10 and 50 muM) for 30 min, phosphorylated ERK and JNK stimulated by LPS and IFN-gamma were markedly inhibited in a concentration dependent manner."
12694879
reach
"As shown in XREF_FIG, LPS treatment alone did not cause significant JNK activation or p38 MAPK activation as reflected by the low p-JNK and pp38 MAPK levels relative to total JNK and p38 MAPK levels."
22028977
reach
"Conclusions: These findings suggest that the activation of JNK induced by LPS is not involved in the modulation of astrocytic GS by 2-AG."
35295462
reach
"Inhibition of the Tec kinases with LFM-A13 decreased LPS induced JNK activation in a dose dependent manner (XREF_FIG), an effect that was not observed with the inactive homolog LFM-A11."
19393603
reach
"Immunoblot analysis was performed with antibodies specific to p100, p52, phosphorylated IkappaBalpha, and JNK in PBMCs from AOSD patients and HCs treated with LPS for 2 h (XREF_FIG B)."
27537874
reach
"Here we show that Escherichia coli LPS (0111 : B4; 10-25mug/ml), but not phorbol myristate acetate (PMA), activates JNK in human neutrophils in a dose dependent manner."
28611461
reach
"XREF_FIG, 10 ng/ml rPGRN significantly inhibited LPS activated JNK and p38, though PGRN moderately phosphorylate JNK and p38."
32503416
reach
"GM-CSF/IL-3/IL-5 and LPS have been also demonstrated to activate JNK, ERK and p38 [6, 40, 44, 46], and TNF- alpha only JNK and p38 [39, 51]."
9232421
reach
"The clear discrepancy of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11460313
reach
"LPS caused similar hepatic damage in control and hepatocyte specific JNK1/2 deficient mice that was detected by histological analysis of liver sections (XREF_FIG), TUNEL labeling of apoptotic cells in liver sections (XREF_FIG), and serum transaminase activity (XREF_FIG)."
19167327
reach
"Although IFN-gamma fails to induce tryptophan catabolism in NOD dermal fibroblasts, activation of an IFN-gamma-independent pathway i.e. LPS mediated JNK pathway can result in expression of active IDO enzyme."
22662207
reach
"Moreover, LPS was also found to stimulate ERK, p38 MAPK, JNK, and Akt activities in U87 cells."
18616930
reach
"Additionally, TRAF6 but not IRKA1 siRNA attenuated the JNK, Smad2 activation and alpha-SMA expression stimulated by LPS, indicating that TRAF6 is critical for LPS induced activation of JNK."
27399683
reach
"LPS has previously been shown to activate JNK and NF-kappaB signaling pathway and increase expression of pro inflammatory cytokines in activated macrophages and adipose tissues."
28630461
reach
"Furthermore, ELC-D-2 inhibited LPS induced activation of c-Jun N-terminal kinase (JNK), which was associated with suppression of inflammatory mediators and migration of LPS treated BV2 cells."
32007708
reach
"Thus, LPS triggers JNK dependent cytokine production that requires ASK1 activation, but both its effects on permeability and activation of p38 are ASK1 independent."
33857660
reach
"In macrophages, lipopolysaccharide activates ERK, JNK and SAPK, and p38, and all are required for the translation of tumor necrosis factor (J Swantek, M Cobb, T Geppert, unpublished data)."
9069255
reach
"Furthermore, studies with several cell culture systems indicate that lipopolysaccharide (LPS) can activate P38 MAPK, ERK, and JNK signaling [XREF_BIBR]."
27514378
reach
"Co-incubation with U0126, SP600125 and SB202190 significantly suppressed LPS stimulated activation of ERK 1/2, JNK, and p38 MAPK, respectively."
17433832
reach
"In cultured podocytes, AdipoRon attenuated the LPS induced activation of the central inflammatory signalling pathways NF-kappaB-p65, c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase (p38-MAPK) (30%, 36% and 22%, respectively, p < 0.001), reduced the secretion of TNFalpha (32%, p < 0.01), and protected against podocyte apoptosis and migration."
33987714
reach
"Moreover, RNA interference of JIP3 inhibited LPS mediated JNK activation."
12941697
reach
"In addition, using Dox induced Tet-On H9c2 myocardial cells and ERalpha transfected cardiomyocytes to overexpress ERalpha, we observed that activation of the PI3K-Akt signalling pathway is required for E 2, BSA-E 2 and/or ERalpha to significantly abolish the LPS induced JNK1/2 activation, IkappaB degradation, NFkappaB activation and subsequent increases in pro apoptotic proteins and apoptosis in myocardial cells."
20196785
reach
"Gemigliptin also blocked LPS mediated activation of pro inflammatory transcription factors JNK and NF-kappabetavia an Akt and AMP activated protein kinase dependent pathway in vitro XREF_BIBR."
33722535
reach
"In this study, we demonstrated that administration of LPS and D-GalN initiated the activation of ERK, JNK, and p38 MAPK."
28430612
reach
"In the present study, inhibition of ROS production by NAC led to significant decrease in the levels of phosphorylated MAPKs and IkappaBalpha in LPS stimulated microglia, while DGP decreased LPS induce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29890414
reach
"Here, we showed that activation of JNK by LPS contributes to a reduction of Cx43 expression and GJIC in astrocytes via ubiquitin-proteasome pathway, suggesting that inhibition of JNK signaling cascades may provide therapeutic benefit in the development of CNS disorders."
24236122
reach
"DHA attenuated the JNK and Akt pathways activated by LPS in RAW264.7 macrophages (Li et al., 2013)."
34276398
reach
"Microglial LRP1 was also essential for EP to suppress JNK activation induced by lipopolysaccharide."
19586665
reach
"We found that LPS challenge activated JNK1/2, and then induced IkappaB degradation, NFkappaB activation, TNF-alpha up-regulation and subsequent myocardial apoptotic responses."
20196785
reach
"We have previously shown that LPS induces intracellular activation of JNK, downstream synthesis of inducible nitric oxide synthase (iNOS), and release of NO in microglia [XREF_BIBR]."
19615334
reach
"It can reduce inflammatory damage in lipopolysaccharide-caused WI-38 lung fibroblasts by inhibiting NF-κB and JNK signaling pathways, and also inhibit early-stage influenza A virus infection and viral invasion (Wu et al., 2015)."
36118001
reach
"LPS activates the NFκB pathway and all three MAPK pathways (ERK, JNK/SAPK, and p38α), leading to a wide range of cellular responses, including cell differentiation, survival or apoptosis, and inflammatory responses ."
34083739
reach
"Because UTI inhibits the increase in calcium ion influx and intracellular mobilization induced by LPS [XREF_BIBR], it is likely that UTI inhibits LPS induced JNK activation by inhibiting the increase of intracellular calcium ion."
23277816
reach
"Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide induced pulmonary neutrophil influx."
15735060
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"Kang and colleagues reported that sargaquinoic acid of Sargassum siliquastrum suppressed inflammatory response in LPS-stimulated RAW 264.7 macrophages by downregulating NF-κB and c-JNK pathways [100]."
32630301
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"LPS stimulation of peritoneal macrophages from these mice did not activate MEK1, ERK1, and ERK2 but did activate JNK, p38 MAPK, and NF-kappaB."
11163183
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"These results suggest that febuxostat suppresses LPS mediated activation of JNK."
24086554
reach
"LPS activated NF-kappaB and JNK signaling pathways via regulation of miR-127."
29451405
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"Glucocorticoids also inhibit LPS stimulation of JNK and SAPK; overexpression of JNK and SAPK overcomes the TNF-alpha translational block (Swantek et al., 1997)."
10354710
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"2-HF also prevented LPS induced activation of protein kinases p38MAPK and SAPK and JNK."
32800949
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"Alprostadil increases the viability of LPS-stimulated H9C2 cells and attenuates IL-1β, IL-6, IL-17, and TNF-α secretion by modulating Wnt5a, JNK, and NF-κB expression [29]."
35196979
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"Together, these results demonstrate a novel function of the C mannosylated TSR derived peptide motif, to promote LPS induced JNK signaling, and this leads to an enhancement of cytotoxicity via the upregulation of TNF-alpha production."
17602137
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"These results suggested that ASK1 is responsible for LPS-induced activation of the JNK and p38 pathways in human choriodecidua."
32024889
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"Moreover, translational studies with human choriodecidua demonstrated that ASK1 was required for LPS induced activation of JNK and p38 and pro inflammatory cytokine production."
32024889
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"According to our knowledge all other studies, which showed LPS mediated activation of JNK pathway, were done in (tumor) cell line models and therefore difficult to compare."
22461999
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"The current study was designed to test the hypothesis that TIPE2 attenuates LPS-induced ALI through the inhibition of lung inflammation and apoptosis, which may be associated with suppressing NF-κB and JNK activation.Reagents LPS (E. coli 0111:B4) was obtained from Sigma-Aldrich (St. Louis, MO)."
31486847
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"We showed previously that LPS mediated activation of the c-Jun N-terminal kinase (JNK) signaling pathway reduces cardiac Ppara gene expression 5."
26574507
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"An in vitro study of murine Kupffer cells showed that LPS stimulation increased the activation of p38, ERK, and JNK, with the activation of p38 and ERK being the most prominent."
20599223
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"Furthermore, LPS activated NF-kappaB and JNK signal pathways."
29665646
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"While LPS and HSC stimulated activation of JNK (associated with cell death), it also activated NFkB and ERK1/2 (associated with cell survival)."
26031389
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"gambiae RAC1-MAP4K1-MAP3K11-MAP2K7-JNK signaling cascade could provide one mechanism for LPS activation of JNK in An."
22111877
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"LPS stimulation induced a strong phoshorylation of JNK, ERK and p38 after 30 min, which was prevented in the presence of GIP, suggesting that GIP directly inhibits inflammatory activation of macrophag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29884547
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"No changes in the total ERK, JNK and p38 kinase were observed in RAW 264.7 cells when treated with LPS or LPS and RDN for 30 min."
25830385
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"Furthermore, miR-30b participated in the LPS induced activation of JNK and NF-kappaB pathways in HK-2 cells."
29635893
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"As a consequence, ConA challenged IKKbetaDeltaHep mice exhibit a more robust and prolonged JNK activation than mutants animals treated with LPS."
19642868
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"It has also been shown that LPS induced JNK activation is dependent on PKC expression, indicating that PKCs are critically involved at an early stage of LPS mediated signaling (Procyk et al., 2000)."
12818158
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"Sca-1 was induced in sorted Gr1+ Sca1- cells by LPS stimulated JNK activation that was also inhibited by alcohol."
21602669
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"All doses of galloyl-HHDP-glucose inhibited LPS-induced JNK and NF-κB activation."
31481965
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"LPS-induced activation of the JNK and p38 pathways is well known to facilitate the inflammatory response by also inducing cytokine expression as well ."
32024889
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"First, we evaluated several transcription factors, such as p100, phosphorylated IkappaBalpha, and JNK, in monocytes and macrophages treated with LPS, an exogenous TLR4 ligand."
27537874
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"LPS induced JNK activation leads to c-Jun phosphorylation and activation of AP-1 transcription factors."
18803301
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"Furthermore, we have shown that activation of JNK by LPS or IL-1beta results in modification and nuclear export of RXRalpha, leading to suppression of RXRalpha dependent hepatic genes [XREF_BIBR; XREF_BIBR]."
18940178
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"Unlike activators of TLR-2, TLR-9 or IL-1, LPS was still able to activate NF-kappaB, p38 and JNK in such cells, although these responses were delayed [19]."
12072368
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"Based on our direct data, it is clear that LPS induces JNK activation in neutrophils in a dose dependent fashion."
28611461
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"In this model, LPS stimulates alveolar macrophages via the TLR4/CD14/MD2 complex and the MyD88-dependent response, and activates nuclear factor kappa B (NF-κB) and c-Jun N-terminal kinase (JNK) that regulate the secretion of inflammatory mediators such as cytokines (e.g., IL-8, TNF-α, IL-1β, and IL-6) (3)."
31481965
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"ERK activation was not induced by the chemicals tested, while SAPK and JNK and p38 MAPKs were strongly modulated by the sensitizers and LPS, with an increased activation at 1h post-treatment that fell over time but remained above basal values at 6h."
29477863
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"Unlike in the case of NF-kappaB, pretreatment with antioxidants could not reduce LPS induced JNK activation in hepatocyte specific p38alpha knockout mice."
22666632
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"We found that CO activated p38 MAPK, ERK1/2 and Akt, but delayed LPS induced JNK activation in human monocytes."
19956541
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"Ajizian et al. (1999) suggested that activation of ERK is thought to be involved in LPS induced macrophage responses XREF_BIBR; in addition, JNK and p38 are activated by LPS stimulation and they have been postulated to play important roles in controlling iNOS gene expression XREF_BIBR."
22590514
reach
"Peroxiredoxin 1 inhibits lipopolysaccharide induced oxidative stress in lung tissue by regulating P38 and JNK signaling pathway."
28485790
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"Effect of IL-13 on LPS induced c-Jun N-terminal kinase (JNK) activation."
23554645
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"In another study, lipopolysaccharide activation of JNK caused disruption of fatty acid oxidation by a human ventricular derived cardiomyocyte cell line and caused cardiac dysfunction in C57BL/6 mice."
25628006
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"It indicated that LPS stimulate TLR4 signaling to induce the expression of IL‐6 and RANTES through activation of NF‐kB, p38 MAPK and JNK signaling pathways but not ERK, PI3K or mTOR signaling pathways."
34669271
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"LPS (100 ng/ml) led to activation of JNK and p38 which peaked at around 60 min of stimulation."
25953296
reach
"We have recently shown that LPS stimulated neutrophils express monocyte chemoattractant protein 1 (MCP-1), an AP-1-dependent gene, suggesting that LPS activates the c-Jun N-terminal kinase (JNK) pathway in neutrophils."
14699155
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"CWE blocked the LPS-induced degradation of IκBα as well as the activation of JNK, p38 and ERK1/2."
23190501
reach
"Pretreatment with paroxetine in BV2 cells markedly blocked LPS induced JNK1/2 activation, but showed little influence on the activation of p38 and p65 kinases."
24618100
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"Our experimental results demonstrate that LPS inhibits the MAPK and p38 pathway and stimulates the MAPK and Erk and MAPK and JNK pathways in vitro in Human Skin Fibroblast cells."
29643910
reach
"In addition, BGG mediated inhibition of AR prevented LPS induced activation of JNK and p38 and lowered ROS levels, which could inhibit LPS induced apoptosis."
23247009
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"These researchers reported that sesamin inhibited the activation of LPS-induced JNK but not p38 or ERK."
33514693
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"We then examined whether LPS activated the JNK and NF-kappaB signaling pathways and as shown in XREF_FIG (top panel), only low levels of NF-kappaB were found in control astrocytes, but a significant increase in NF-kappaB levels was detected at 6-18 h of LPS treatment (XREF_FIG)."
24236122
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"Although LPS activated three MAP kinases in murine macrophages, only JNK was targeted by CLEN : while LPS activated p38, ERK, and JNK, CLEN only attenuated the LPS induced rise of JNK activation."
28929026
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"In particular, LPS induced JNK p46 phosphorylation states in cGAMP treated adipocytes were markedly lower than in control treated adipocytes, and were comparable with JNK p46 phosphorylation states in cGAMP treated adipocytes in the absence of LPS induction."
28743914
reach
"Importantly, TGF-beta1 clearly inhibited LPS stimulated JNK activity in the cells."
10462047
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"Curcumin also inhibited LPS induced JNK posphorylation."
16678799
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"Mechanistically, our recent reports reveal that super-low dose LPS preferentially utilizes cell surface TLR4 receptor, (rather than endocytosed TLR4), and activates IRAK-1-mediated signaling and JNK activation [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26690561
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"Second, we examined LPS induced JNK and NF-kappaB signaling activation in BMDMs from Mcpip1 +/+ or Mcpip1 -/- mice."
21115689
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"Previously, both C5a and LPS were shown to activate NF-kappaB, p38 MAPK, Erk1/2, JNK and PI3K signaling pathways in human monocytes XREF_BIBR XREF_BIBR."
27624143
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"CT significantly attenuated LPS induced activation of JNK and c-Jun, but not ERK and p38, in a concentration dependent manner."
25009700
reach
"Further studies showed that LPS could directly activate JNK and MAPK signaling through TLR4 in HCC cells."
25053598
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"Our data demonstrated that melittin and bee venom reduces LPS and SNP induced activation of JNK signals."
18507870
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"It is, however, also possible that LPS induced activation of JNK and p38 MAPK may not be mediated via TLR4 in hepatocytes."
21743791
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"The inhibition of these two genes may be induced by transforming growth factor beta (TGF-beta), the expression of which is significantly increased in MA treated macrophages [14], and which inhibits LP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15135318
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"It also inhibits the LPS mediated JNK 1/2 activation and significantly blocks the LPS induced AP-1 activation [XREF_BIBR]."
28904554
reach
"Western blotting indicated that LPS upregulated the phosphorylated forms of extracellular-signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) but that this was suppressed by 30 muM TS treatment."
29258263
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"LPS challenge activated SAPK and JNK activity and enhanced phagocytosis of AMs without altering phosphatase activity in these cells."
10638667
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"While CO activated p38 MAPK, ERK1/2 and Akt and perhaps more importantly delayed LPS induced JNK activation, inhibitors of these kinase pathways failed to substantially block CO suppression as measured by effects on IL-1beta."
19956541
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"JNK and p38 MAPKs are predominantly activated not only by stress such as osmotic changes and heat shock but also by inflammatory cytokines TNF-alpha and IL-1beta and bacterial lipopolysaccharide (LPS) [XREF_BIBR - XREF_BIBR]."
20396387
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"Activation of JNK by LPS results in modification of RXRalpha, leading to suppression of PXR and RXRalpha hepatic target genes 69."
22609277
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"Pretreatment with Apo (30muM) for 24h inhibited LPS induced activation of JNK and the nuclear accumulation of ATF4."
27939990
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"In addition, blank Lipo did not modify the activation of p38, JNK, or ERK induced by LPS, as shown in XREF_FIG."
29317816
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"On the other hand, baseline ERK1/2 activity and LPS induced JNK1/2 activation were blunted by paroxetine pre-administration, suggesting paroxetine mediated anti-microglia activation is potentially via inhibition of JNK1/2 and (or) ERK1/2 activities."
24618100
reach
"Pg LPS also induced ERK, p38, and JNK activation, and Pg LPS induced PAI-1 expression was inhibited by ERK/p38/JNK inhibitor pretreatment."
24500480
reach
"In addition to these pathways, LPS also mediates the activation of p38, JNK, and Akt signaling pathways."
20717897
eidos
"Moreover , LPS stimulation inhibited miR-15a , and increased the expression of JNK , NLRP3 , caspase1 , RIPK1 , RIPK3 , MLKL ."
34329475
reach
"LPS activates the JNK activator protein-1 (AP-1) signaling pathway and leads to the upregulation of A-FABP and the release of proinflammatory cytokines in macrophages."
29850615
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"Thus, in an animal model, LPS administration activates JNK signaling in the liver as early as 1 hour, with evidence for prolonged JNK activity lasting at least 6 hours."
15312234
reach
"The results indicated that DHT had no effect on LPS mediated JNK1/2, ERK1/2 as well as p38 signaling."
24417898
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"In addition, alpha-cubebenoate inhibited the LPS induced activation of JNK, but not those of ERK and p38 MAPK in mouse peritoneal macrophages."
24561384
reach
"However, from 6 to 24hours the phospho-JNK-2 and JNK-2 ratio remained low, whereas the phospho-JNK-1 and JNK-1 ratio was significantly increased, suggesting that LPS induced neuroinflammation might affect differentially both JNK isoforms."
28808322
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"The GJ extract dose-dependently inhibited LPS induced JNK, and p38 MAPK, and partially inhibited COX-2 in BV-2 cells."
26221479
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"We found that LPS induced IL-12 p40 protein and mRNA in a time- and concentration dependent manner in PMA treated THP-1 macrophages, and that LPS activated JNK and p38 mitogen activated protein (MAP) kinase, but not extracellular signal regulated kinase, in PMA treated THP-1 cells."
12847227
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"LPS can interact with TLR2, a major member of the TLR family, to activate the downstream protein nuclear factor-κB (NF-κB), P38 mitogen-activated protein kinase (MAPK) and C-Jun N-terminal kinase (JNK) of TLR2 and regulate the production of LPS-induced pro-inflammatory cytokines such as IL656."
35581339
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"In fact, the first evidence for this crosstalk was the observation that chemical inhibition of p38alpha and p38beta strongly increased the activation of JNK, which was induced by IL-1 and sorbitol in epithelial cells and by LPS in macrophages [XREF_BIBR]."
23497067
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"These results suggest that enhancement of LPS induced JNK activation by IFN-gamma associated with inhibition of MAPK phosphatase-1 may be one of the mechanisms of additive effects between IFN-gamma and LPS in fibroblasts."
18950753
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"Enhancement of lipopolysaccharide stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirus mediated inhibition of inhibitory kappa B kinase signalling."
12839879
reach
"Since recent studies showed that c-Jun N-terminal kinase (JNK), one of the mitogen activated protein kinases, plays an important role in LPS signalling, we focused here on the inhibitory action of TGF-beta1 on LPS stimulated JNK activity in mouse macrophages."
10462047
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"However, JNK and p38 activation by LPS was completely blocked after H 2 O 2 pretreatment for 18 h, although H 2 O 2 per se has been known to cause the activation of JNK and p38 (Cano and Mahadevan, 19[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10936514
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"Confocal microscopy images of the neutrophils stained for DNA (DAPI, blue) and immunostained for p-JNK (red) confirm the activation of JNK in neutrophils treated with LPS."
28611461
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"Herein, we show that the Tec kinases are activated in LPS stimulated human neutrophils and that inhibition of the Tec kinases, with leflunomide metabolite analog (LFM-A13), decreased LPS induced JNK, but not p38, activity."
19393603
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"We explored the protein expression of Wnt5a, JNK, p-JNK, and NF-kappaB in H9c2 cells treated with LPS by Western blotting."
31312872
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"All three MAPK pathways i.e. p38, JNK and SAPK and ERK are activated by LPS in monocytes XREF_BIBR."
22506067
reach
"XREF_BIBR, LPS induced JNK activation was also found to be reduced in a mouse monocytic cell line that was transiently transfected with siRNAs against TAK1."
22348103
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"SCM-198 inhibited activation of JNK and NF-kB pathways induced by LPS in BV-2 cells."
25134526
reach
"Aromadendrin significantly attenuated LPS induced activation of JNK, but not ERK and p38, in a concentration dependent manner."
24265867
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"Here, our results demonstrated that L-4F could not inhibited the IFN-gamma producing cells in tumor tissues and L-4F inhibited phosphorylation of LPS induced JNK in mouse RAW264.7 macrophages, but not inhibit p38MAPK."
29245934
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"However, further studies are necessary to clearly elucidate the exact mechanism by which aromadendrin inhibits LPS induced activation of JNK signaling pathway and the possible crosstalk between NF-kappaB activation and JNK signaling pathway."
24265867
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"Since LPS has been shown to activate the ERK, JNK, and p38 MAP kinases in murine macrophages, we investigated whether LPS activated MAP kinases in the D1 cells."
9841930
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"Meanwhile, shizukaol B concentration- and time-dependently inhibited LPS mediated c-Jun N-terminal kinase 1/2 (JNK) activation, but had little effect on extracellular signal regulated kinase 1/2 or p38 phosphorylation."
28178617
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"The clear difference of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11460313
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"To further confirm the effect of MCPIP1 on LPS stimulated JNK and NF-kappaB signaling activation, we transfected MCPIP1 and control vectors into Raw264.7 cells."
21115689
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"To confirm that the observed effect was due to Lipo and GOT, blank Lipo was used as control, and the experiments showed that Lipo without encapsulated GOT did not modify the activation of p38 or JNK induced by LPS, as shown in XREF_FIG."
29317816
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"Moreover, LPS could induce the activation of p38 mitogen activated protein kinase (MAPK) and c-jun N-terminal kinase but not extracellular signal regulated kinase."
12473078
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"In addition, MEKK3 has the capacity to promote activation of the p38 and JNK signaling pathway induced by LPS."
33644040
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"Khan et al. [63] found that LPS induces activation of c-jun N-terminal kinase (JNK), which is upstream of NADPH oxidase, in a toll-like receptor 4 (TLR4)-dependent manner in neutrophils."
| PMC
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"While LPS stimulation induced the activation of ERK1/2, SAPK and JNK, and p38 MAPK in RAW 264.7 cells, Shinbaro3 treatment suppressed the LPS induced phosphorylation of these MAPKs in a concentration dependent manner (XREF_FIG)."
29849490
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"For the first time, we found that LPS, but not PMA, activates JNK in a dose dependent fashion, and that JNK activation is responsible for LPS-, but not PMA-, mediated ROS production and subsequent Nox dependent suicidal NETosis."
28611461
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"The clear difference of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11360925
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"However, suppression of miR-29b reduced LPS activated NF-kappaB and JNK pathways in both HUVEC and Eahy926 cells."
29665646
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"LPS mediates the inflammatory response by activating ERKs, p38 MAPK, and JNKs."
24195792
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"LPS activation of Erk1/2, SAPK/JNK, and p38 , evident as an increase in the phosphorylated form of these kinases, occurred within 30 minutes and was not affected by fibrinogen or TG2-cross-linked fibrinogen (Figure 4A–D)."
35158413
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"However, LPS induced JNK and p38 MAPK activation was inhibited by paclitaxel pretreatment), although to a lesser degree than that observed in spleen cells.In the present studies, we show that paclitax[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10988356
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"LPS treatment resulted in the activation of hepatic JNK coinciding with marked reduction in nuclear RXRalpha levels, and the rapid appearance of RXRalpha in the cytosol."
15312234
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"In contrast, LPS caused very little activation (~ 1.5-fold stimulation) of the JNK MAP kinase and only modest activation (2-2.5-fold stimulation) of MAPKAP kinase-2."
9841930
reach
"Polyozellin inhibits nitric oxide production by down-regulating LPS induced activity of NF-kappaB and SAPK and JNK in RAW 264.7 cells."
16783701
reach
"In addition, HTMC interfered LPS induced c-Jun N-terminal kinase 1/2 (JNK) phosphorylation in a time- and concentration dependent manner."
26852953
reach
"Tomatidine suppresses inflammation in LPS-stimulated murine macrophages by inhibiting the NF-κB and JNK signaling pathways [15]."
32628132
reach
"We found that TRAF2 deficiency in macrophages had no effect on LPS stimulated JNK activation and only partially inhibited IKK activation."
25565375
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"In this study, although we focused on the inhibitory action of TGF-beta1 in LPS induced JNK, it also remains of interest to explore this cytokine action toward other MAP kinases that are activated in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10462047
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"LPS stimulation of human monocytes activates several intracellular signaling pathways that include the IkappaB kinase (IKK) and nuclear factor-kappaB (NF-kappaB) pathway and three mitogen activated protein kinase (MAPK) pathways : extracellular signal regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK) and p38 [XREF_BIBR]."
22920833
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"In this work, Fuol pre-treatment markedly prevented the LPS-induced activation of JNK, p38, and ERK1/2 (Figure 6)."
32079242
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"These results suggest that SFEIO exerts its anti-inflammatory effects in LPS activated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-kappaB."
27822172
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"Decursin negatively regulates LPS induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4"
32158615
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"LPS-activated microglia express TNF-α and JNK, which together precede cell death through inflammation and apoptosis; therefore, the inhibition of TNF-α- TNF-α receptor (TNFR1) or JNK signaling exerts neuroprotective effects [37]."
28671636
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"Therefore, we propose that the improvement of septic hypotension by octyl caffeate might not merely be due to its inhibition of iNOS dependent NO generation, but also to its antioxidant scavenging act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12694879
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"The present data demonstrated that CT significantly suppresses LPS induced activation of JNK and c-jun (XREF_FIG) and Akt (XREF_FIG) signaling pathways."
25009700
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"TAN relieved LPS induced inflammatory injury of human HaCaT cells via down-regulating miR-122 and then inactivating JNK and NF-kappaB pathways."
30632205
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"The JNK inhibitor SP600125, at a concentration of 20 muM, has been reported to sufficiently inhibit LPS induced JNK activation in myeloid cells."
21602669
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"Interestingly, LPS stimulation did not elicit activation of ERK1/2 but indeed induced marked activation of JNK1/2, p38, and p65 and NF-kappaB in a time dependent manner."
24618100
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"Emodin suppresses LPS-induced JNK activation, and subsequently regulates the downstream mediators Nur77 and c-Jun, which results in the reduction of inflammatory cytokines."
35370650
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"Pretreating murine macrophages (RAW 264.7) with luteolin inhibited LPS stimulated TNFalpha and IL-6 release, which was associated with blockage of LPS induced activation of nuclear factor kappa B (NF-kappaB) and mitogen activated protein kinase (MAPK) family members ERK, p38, and JNK [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
18991571
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"Together, our data suggest that TREM2 and DAP12 complex negatively regulates LPS induced inflammatory responses by modulating the JNK signaling pathway in microglia."
28680398
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"JNK and p38 are strongly activated by IL-1, TNF-alpha, cell stress, and LPS."
9625767
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"All results imply that GLP-2 inhibits LPS induced microglia activation by collectively regulating ERK1/2, JNK1/2 and p65."
26861286
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"On the other hand, SAPK and JNK was not significantly activated by P. gingivalis LPS and E. coli LPS (XREF_FIG.3)."
23554896
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"Furthermore, regarding COX-independent mechanisms, Dx has been demonstrated to inhibit Il-12p40 expression in LPS-stimulated human monocytic cells by down-regulating the activation of JNK MAPK pathway [20]."
32751993
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"In agreement with the previous results, chloroform- and hexane-soluble fractions of A. holophylla and their active compounds significantly inhibited the LPS induced activation JNK, thereby suppressing the secretion of IL6, IL-1beta, and TNF-alpha."
33478055
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"Indeed, LPS induces p38, JNK, and ERK activation in BV2 cells [165,166]."
| PMC
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"We demonstrate that LPS stimulation may activate intracellular MAPK and JNK and NF-kappaB signaling pathways and thus induce cell apoptosis."
31205455
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"BGG reduces LPS induced activation of JNK and p38."
23247009
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"LPS induced JNK activation in WT lung cells and this response was further enhanced in ARTg lung cells (XREF_FIG)."
20007578
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"To assess further the contribution of JNK signaling to increased BNP expression, we treated human AC16 cardiomyocytes with E. coli LPS, which activates JNK signaling."
32324169
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"Moreover, we found that p38MAPK, JNK, and ERK were activated by APAP or LPS alone or in association."
19589095
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"We found that while both C2-ceramide and LPS activated c-Jun N-terminal kinase (JNK), only LPS also activated extracellular signal regulated kinases (ERKs)."
9880559
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"Because ligation of TLR4 triggers the activation of MAP kinase and NF-kappaB, leading to production of proinflammatory cytokines through the MyD88 dependent pathway, we investigated the activation of MAP kinase such as JNK, p38, and ERK1/2 in macrophages treated with LPS or 2,000 kDa gamma-PGA."
19294383
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"LPS activates ERK, p38 and JNK pathways in BMDMs."
29354064
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"Our studies indicated that ERK1/2, p38, JNK, NF-kappaB, AP-1 can be activated by LPS treatment."
27713159
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"It has been reported that LPS induced JNK, ERK, and p38 MAPK signal pathways mediate inflammatory responses in various cell types, and transcription factors positively regulate the inflammatory genes."
27746869
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"PLA and LPS Activate the JNK Signaling Pathway in NCI-H292 Cells."
28116315
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"It is known that LPS activates the NF-kappaB pathway and all three MAPK pathways (ERK, JNK and SAPK, and p38alpha), leading to a wide range of cellular responses, including cell differentiation, survival or apoptosis, and inflammatory responses [XREF_BIBR]."
26114754
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"In addition, PDTC potentiated LPS stimulated c-Jun N-terminal kinase (JNK), p38 mitogen activated protein kinase (MAP kinase) and MAP kinase activated protein kinase-2 activity (the downstream target of p38 MAP kinase)."
12839879
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"Simvastatin also inhibited LPS stimulated ERK but not p38 MAPK and JNK."
18625914
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"However, administration of ketamine significantly decreased LPS induced activation of c-Jun N-terminal kinase and translocation of c-Jun and c-Fos."
18191973
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"Taken together, these data indicated that DAP12 negatively regulates LPS induced inflammatory responses in microglia by modulating the activity of JNK signaling pathway."
28680398
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"Moreover, tan IIA significantly alleviated the phosphorylation of IkappaBalpha, nuclear factor-kappa B (NF-kappaB), p38, and JNK induced by LPS."
32860868
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"We found that Nec-1 treatment abolished P38 and JNK activation induced by LPS, poly I:C, or TNF plus zVAD in peritoneal macrophages (Fig. 1d–f)."
30442927
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"STAT signaling is critical for macrophage polarization processes, for example LPS activates JNK mediated tyrosine phosphorylation and the dimerization of STAT1 [XREF_BIBR, XREF_BIBR]."
26620549
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"The JNK and p38 MAP kinase pathway was activated by the bacterial LPS, TNF, IL-1 and FASL TGFB."
28899359
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"As concerns human evidence, we demonstrated that a specific ASK1 inhibitor, K811, suppressed the LPS-induced activation of JNK and p38 and inflammatory responses related to preterm birth in human choriodecidua."
32024889
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"From the time points of LPS’ effect, we hypothesized that activation of JNK by LPS does not directly affect USP13 ubiquitination."
33169399
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"These data strongly suggest that LPS specifically induces neuronal cells to express chemokines in a JNK dependent manner, and we showed that LPS induced KC release in neurons was completely abrogated in the presence of a specific JNK inhibitor."
23034047
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"LPS also activated JNK1/2, p38 and ERK1/2 MAP kinases."
17149706
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"Mangiferin inhibits LPS induced chronic inflammation by regulating MAPK (Mitogen Activated Protein Kinase) signalling pathway through alteration in the expressions of ERK (Extracellular signal regulat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25064341
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"Selenomethionine alleviates LPS induced JNK and NLRP3 inflammasome dependent necroptosis by modulating miR-15a and oxidative stress in chicken lungs."
34329475
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"LPS treatment of HGFs resulted in the activation of ERK1/2, p38 and JNK."
23278498
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"Our results demonstrated that LPS activated Akt and PI3K, p38, JNK, ERKK, and NF-kappaB pathways in hPDLCs."
22683003
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"Lipopolysaccharide (LPS) induced JNK activation to mediate tumor necrosis factor-alpha (TNF-alpha) production which could trigger macrophages apoptosis [12]."
29751034
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"The kinase active mutant G2019S, in particular, enhanced both basal and LPS induced levels of phosphorylated (activated) p38 and JNK, whereas the effects of other LRRK2 mutants on p38 and JNK activation were variable."
22496842
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"LPS stimulation induced a strong phoshorylation of JNK, ERK and p38after 30min, which was prevented in the presence of GIP (XREF_FIG F-H), suggesting that GIP directly inhibits inflammatory activation of macrophages invitro."
29884547
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"Confirming prior work, LPS rapidly induces activation of p38, JNK and ERK (XREF_FIG)."
31969384
eidos
"Previous studies have shown that ERK , JNK , and p38 are closely bound up with various inflammatory diseases , such as acute lung injury , and can be activated by LPS , TNF , and other irritants ."
32005962
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"We first examined the effect of quercetin on P. intermedia LPS induced activation of JNK and p38."
24040572
reach
"Furthermore, BRE pre-treatment of the cells for 1 h significantly decreased ERK and JNK activation that was induced by LPS (XREF_FIG)."
33505935
reach
"Such antioxidant activities can contribute to immunoregulatory and anti-inflammatory abilities.Furthermore, the results indicated that both hyalomin-A1 and B1 significantly suppressed the LPS-induced activation of the JNK subgroup of the MAPK signaling pathway by blocking JNK phosphorylation and, consequently, led to a reduction in MCP-1, IFN-γ, and tumor necrosis factor-α genes."
34795699
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"The pharmacologic inhibition of PKR activity by 2-AP significantly attenuated the LPS induced activation of JNK and p38 MAPK, leading to the inhibition of LPS induced ATX expression."
19027716
eidos
"From the time points of LPS ' effect , we hypothesized that activation of JNK by LPS does not directly affect USP13 ubiquitination ."
33169399
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"First, phosphorylation of MAPK, a signaling protein representative of ERK, JNK, and p38, activated by LPS, was confirmed by western blotting."
33572173
reach
"Mechanistically, we demonstrate that LPS activated JNK and PI3K signaling pathways are involved in suppressing Pdcd4 expression and resultant TNF-alpha production in macrophages (XREF_FIG and XREF_FIG)."
20607724
reach
"LPS activates JNK and MAPK via TLR4 in HCC cells, whereas inhibition of JNK/MAPK significantly reduces EMT occurrence [262] ."
33925827
reach
"To provide further evidence of CD36-dependence of LPS- and bacterium induced JNK phosphorylation, we tested the ability of amphipathic alpha-helical peptides, previously shown to be CD36 receptor agonists, to alter JNK1/2 activation induced by LPS and E. coli."
18981136
reach
"In HEK 293 cells exogenously expressing TLR4, MD2 and CD14, co-expression of JIP3 significantly increased the complex formation of TLR4-JNK and LPS mediated JNK activation."
12941697
reach
"These results suggested that CuEO exerted anti-inflammatory effects in LPS stimulated RAW 264.7 cells via inhibition of NF-kappaB and mitogen activated protein kinases ERK and JNK signaling; the chemical could be used as a source of anti-inflammatory agents as well as dietary complement for health promotion."
26425131
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"We show that treatment of differentiated THP-1 cells with purified Stx1 resulted in prolonged activation of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK) cascades, and lipopolysaccharides (LPS) rapidly triggered transient activation of JNK and p38 and prolonged activation of extracellular signal regulated kinase cascades."
16301326
reach
"Neither ageing nor LPS treatment activated JNK (not shown)."
23028880
reach
"These derivatives of G-Rh2 reduce LPS induced production of TNF-alpha, IL-6, and IL-1beta as well as the activities of p38 MAPK, JNK, and NF-kappaB, showing greater anti-inflammatory effects than that of G-Rh2 XREF_BIBR, XREF_BIBR, in turn suggesting that improving bioavailability and water solubility of ginsenosides could also improve their anti-inflammatory effects."
29021688
reach
"We observed that LPS activated the p42/44 MAPK and JNK and SAPK in a time dependent manner, but there was no increase in the LPS induced phosphorylation of p38-MAPK in hNPECs."
20138035
reach
"As seen in Figure XREF_FIG A-D, phosphorylation of p38, c-Jun, JNK and NF-kappaB p65 was significantly induced by LPS (all P <.05)."
31769187
reach
"This is the first study to show that LPS induces JNK dependent hepatocyte apoptosis in vitro in the virtual absence of Kupffer and stellate cells, and that LPS 's effect is additive to the apoptosis caused by bile acids or Fas ligand."
21743791
reach
"To confirm the nuclear translocation results, phosphorylation level of JNK, p38 and NF-kappaB p65 were detected by Western blotting, which showed that JNK and c-Jun, p38, and NF-kappaB signalings were remarkably activated by 10mug/mL LPS and 100mug/mL ox-LDL, but not by 100mug/mL CHC except a slight up-regulation of p-JNK."
29133791
reach
"Infection of RASMCs with an adenovirus encoding either inhibitory kappa Balpha or a dominant negative IKKbeta potentiated LPS stimulated JNK activity."
12839879
eidos
"For example , LPS does not initiate the transcription of Ifnb or activate JNK or NFkappaB in neurons ; raising doubts whether these cells can signal through the MyD88 or TRIF pathway ( Okun et al ., 2011 ) ."
28947376
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"Meanwhile, p38 and JNK and NF-kappaB pathways induced by LPS were repressed by gastrodin."
31769187
reach
"These pathways overlap with those initiated by FcRs, but are distinct from the IkappaBalpha and NF-kappaB and p38 and SAPK dependent pathways triggered by LPS."
11602640
reach
"On the other hand, SAPK and JNK was not significantly activated by P. gingivalis LPS and E. coli LPS (XREF_FIG.3)."
23554896
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR The mechanism by which LPS activates JNK and p38 MAPK in hepatocytes is unclear at this time."
21743791
reach
"DOE inhibits LPS triggered activation of JNK to suppress HMGB1 release in RAW 264.7 cells."
28403838
reach
"LPS stimulation markedly increases the degradation of IkB-alpha and (JNK) along with activation of the NF-kB pathway resulting in the secretion of pro inflammatory factors."
33113418
reach
"SS2-and PMA-induced p38 MAPK and ERK1/2 activation and LPS-induced JNK/SAPK activation were downstream of ROS generation, and the subsequent activation of these kinases regulate NETs release (27)."
30581435
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"For example, berberine suppressed the activation/phosphorylation of p38, JNK, and ERK and suppressed the expression of IL‑1β, IL‐6 in LPS‐stimulated macrophages.29, 30 Hesperidin inhibited LPS‑induced activation of JNK and p38 MAPK pathways and prevented LPS‐induced endotoxicity in rats."
34061465
reach
"Moreover, LPS can activate JNK, a member of the MAPK family."
31486847
reach
"We first confirmed that JNK is activated by LPS by performing time course experiments on LPS induced JNK activation."
19577630
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"The results suggest that inhibition of p38 MAPK increases LPS induced JNK activity, which leads to stabilisation of iNOS mRNA and increased production of NO in activated macrophages."
16504051
eidos
"In the present study , ERK , JNK and p38 were notably activated by LPS in renal tissues and HBZY-1 cells ."
| PMC
reach
"Pretreatment with TAK-242 inhibited the activation of JNK induced by LPS, indicating that JNK is located downstream of TLR4 signaling."
33760172
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"The phosphorylation of JNK, p38 MAPK, and ERK1/2 increased in cells treated with LPS alone."
25810745
reach
"As shown in XREF_FIG, ERK1/2, p38, and JNK phosphorylation expression levels markedly increased in the cells treated with LPS alone."
24465855
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"These results indicate that EGS selectively inhibits the excessive production of inflammatory mediators in LPS‑stimulated murine macrophages by reducing the activation of JNK, suggesting that EGS is a candidate for modulating severe inflammation."
26781201
reach
"At 1 h, LPS induced JNK activation in the presence of CO reached the same intensity as the maximum effect of LPS alone (seen at 30 min), even as the LPS-only response began to wane."
19956541
reach
"As shown in XREF_FIG, BGG treatment attenuated the LPS induced activation of JNK and p38."
23247009
reach
"Moreover, PGN and LPS induce differential activation of MAP kinases, with LPS strongly inducing all three families of kinases (ERK, JNK, and p38), whereas PGN only induces ERK and JNK without affecting p38."
23264652
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"Of note, treatment of adipocytes with metformin at a relatively low dose, e.g., 5 muM, or for a relatively short time, e.g., 6 h, appeared to not suppress or even increase LPS induced JNK p46 phosphorylation states (XREF_FIG)."
28559290
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"One of the targets of the Tpl2 and ERK transduced LPS signals is the 3 ' ARE of the TNF-alpha mRNA, which may also be the target of the LPS activated JNK and p38 MAPK pathways (Kontoyiannis et al. 199[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11163183
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"We have previously shown that inducible inflammatory mediator production is inhibited by a post-transcriptional mechanism, since mycolactone does not modulate the LPS dependent activation of ERK, JNK, p38 MAPK or NFkappaB and induced levels of mRNA are maintained or even enhanced XREF_BIBR."
24699819
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"To address the question of whether epithelial cells can sense bacterial products once the products are intracellular, we found that LPS -- presented to the cytosol either through infection with an inv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11498296
reach
"Additionally, MKP-1 deficiency enhanced LPS stimulated JNK and p38 activities but had little effect on ERK activity in primary macrophage cell culture (Zhao et al., 2006)."
24842488
reach
"Fig. 2A shows that LPS stimulation of JNK activity in the cells was dose dependent."
10462047
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"These results were similar to those obtained by Baranova et al., who were interested in human CD36 in LPS induced JNK mediated signaling XREF_BIBR."
26976286
reach
"LPS sensitized hypoxic-ischemia induced JNK activation in microglia, microvascular endothelial cells, neurons, and oligodendrocyte progenitors."
25540015
reach
"Chiu et al. reported that tomatidine inhibits the inflammatory response in LPS-stimulated mouse macrophages by suppressing the NF-κB and JNK signaling pathways [15]."
32628132
reach
"In this mechanism, TNF (and LPS) specifically activate NF-kappaB and JNK dependent c-Fos (a subunit of AP-1) contributing to OC formation [XREF_BIBR]."
25261746
reach
"It has been reported that LPS activates the MEK and JNK pathways, which is associated with the production of TNF-alpha and IL-6 XREF_BIBR, XREF_BIBR."
26722218
reach
"Specifically, LPS activation of the p38, JNK1/2 and ERK1/2 MAPK signaling pathways that regulate proinflammatory gene expression in macrophages were significantly reduced in PTEN -/- macrophages, which have enhanced Akt activation."
19447494
reach
"MAP3K21 can suppress LPS induced activation of the JNK or ERK pathways, but does not have an effect on LPS induced p38 or NF-kappaB activation."
32547963
reach
"In the present study, LPS treatment was shown to induce JNK activation and NF-kappaB upregulation in primary rat astrocytes."
24236122
reach
"In this study S. abortus LPS was used to activate both uterine NF-kappaB and JNK activation and cause preterm birth."
26183892
reach
"Polyozellin inhibits nitric oxide production by down-regulating LPS induced activity of NF-kappaB and SAPK and JNK in RAW 264.7 cells."
16783701
reach
"At concentrations of 0.5, 0.75, and 1mg/mL, treatment with BPTS inhibited levels of expression of LPS induced NF-kappaB and MAPKs (ERK, JNK, and p38) as well as production of proinflammatory mediators, such as nitric oxide (NO), prostaglandin E 2 (PGE 2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) by LPS."
22899961
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"In the present study, AUDA attenuated phosphorylation of P38 but not JNK or ERK induced by LPS or IFN-gamma, indicating that the P38-MAPK pathway could represent a molecular target for sEH inhibition and thus mediate its anti-inflammatory properties in activated microglia."
29262558
reach
"CPT-2-Me-cAMP also prevented LPS induced activation of JNK and inhibition of AKT."
21743791
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"LPS-Induced Alteration of the JNK/Akt and AMPK/mTOR Signaling Pathways."
| PMC
reach
"The amounts of non phosphorylated p38 ERK 1/2 and JNK were treated with or without LPS and EPCP1-2."
29194423
reach
"LPS was shown to induce JNK activation in normal microglia, which led to increased production of inflammatory cytokines [XREF_BIBR]."
29050210
reach
"For instance, bacterial lipopolysaccharide (LPS), a conserved component of the outer membrane of a gram-negative bacterium, has been shown to initiate JNK activation in monocyte/macrophage cells, and other types of cells [74,75,76]."
34502556
reach
"In addition, ambuic acid suppressed the phosphorylation of extracellular signal regulated kinase 1/2 (ERK 1/2) and c-Jun N-terminal kinase (JNK) induced by LPS."
30116402
reach
"We previously have shown that the mitogen activated protein kinases (MAPK) p38 [XREF_BIBR] and JNK [XREF_BIBR] are activated by LPS in human neutrophils, with each regulating specific effector functions."
19393603
reach
"The anti-inflammatory effects of CO have also been associated with an early delay in LPS induced JNK activation and subsequent impairment of AP-1 signaling XREF_BIBR."
19956541
reach
"It is also well established that JNK and IKK are activated by LPS or the proinflammatory cytokines."
10626894
reach
"SB220025 increases LPS induced JNK activity."
16504051
reach
"LPS induced phosphorylation of JNK, ERK 1/2 and IKKbeta was higher in MCPIP -/- indicating that MCPIP is essential for down regulation of LPS induced JNK and NFkappaB activation."
22223213
reach
"LPS also activates c-Jun N-terminal kinase (JNK), as assessed by in vitro kinase assays."
12717385
reach
"Rather, MLK4 appears to be able to inhibit lipopolysaccharides (LPS)-induced activation of the JNK or ERK pathways, but does not have effect on LPS induced p38 or NF-kappaB activation."
21602844
reach
"In macrophages and other types of cells, LPS activates three subclasses of MAPKs: extracellular signal-regulated kinase (ERK), c-Jun-terminal kinase (JNK) and p38."
21160452
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"Immunobloting data revealed the abilities of TAKI to inhibit TAK1, IKK, ERK, p38 and JNK activation induced by LPS."
26381601
reach
"Overall, our studies show that an indazole derivative, Cyy-272, is effective in suppressing LPS induced JNK activation and inflammatory signaling."
34280409
reach
"MAPK signaling, including JNK, ERK1/2 and p38 MAPK, which can be activated by LPS and TNF-alpha, is reported to play an important role in LPS induced inflammation [XREF_BIBR]."
27191745
reach
"D-JNKI supresses LPS induced JNK activation in mouse myometrium and fetal brain."
26183892
reach
"Although these inhibitory effects are coherent with the NO pro apoptotic role, LPS and IFN-gamma can also induce astrocyte death by activating a broad range of alternative pathways such as p38 MAPK and JNK XREF_BIBR - XREF_BIBR, in spite of its effects on Akt and p65-c-Rel."
21779400
reach
"Upon stimulation by LPS via toll like receptor 4 (TLR4), JNK is activated, leading to the induction of c-Jun phosphorylation and its recruitment to a highly conserved AP-1 consensus binding motif located within the AFABP gene promoter."
33815359
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"In addition to the effect on LPS induced JNK activation and actin assembly, our results suggest that the Tec kinases regulate the expression of TNF-alpha, IL-6, MCP-1, and IL-1beta in human neutrophils after exposure to LPS (XREF_FIG)."
19393603
reach
"Moreover both forms of LPS activated NF-kappaB, p38 MAPK and ERK pathways, but not the SAPK and JNK pathway."
23554896
reach
"While LPS stimulation induced the activation of ERK1/2, SAPK and JNK, and p38 MAPK in RAW 264.7 cells, Shinbaro3 treatment suppressed the LPS induced phosphorylation of these MAPKs in a concentration dependent manner (XREF_FIG)."
29849490
reach
"Furthermore, NGR1 attenuated LPS activated NF-kappaB and JNK pathways in MRC-5 cells via up-regulation of miR-132."
30622031
reach
"RNA interference experiments indicate that GCK is required for the maximal activation of JNK by LPS, lipid A, poly (IC), and, to a lesser extent, IL-1 and engagement of CD40."
15456887
reach
"Recent studies have provided evidence that LPS activates MAPK (ERK1/2, p38, and JNK1/2) and JAK and STAT signalling pathways and thereby causes intracellular inflammation [XREF_BIBR, XREF_BIBR]."
28751937
reach
"Although catalase overexpression itself failed to affect the pan and phosphorylated protein expression of JNK and p38, it nullified or significantly attenuated LPS induced activation of JNK and p38."
22902401
reach
"It is now clear that, in macrophages activation of ERK (by LPS) but not JNK is mediated via phosphorylation of NFkappaB1 p105 by IKK (Banerjee et al., 2006; Beinke and Ley, 2004; Beinke et al., 2004; [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17507094
reach
"In addition, Cortex Phellodendri inhibited inducible nitric oxide synthase (iNOS), activated nuclear factor-kappaB (NF-kappaB) by degradation and phosphorylation of IkappaBalpha, and attenuated phosphorylation of mitogen activated protein kinases such as ERK1/2, p38, and JNK in mice treated with lipopolysaccharide [XREF_BIBR]."
25834623
reach
"LPS treatment has been reported to induce ERK, JNK, and p38 activation in macrophages [XREF_BIBR]."
19294383
reach
"In contrast, in neuronal cultures, LPS activated JNK but not ERK1/2 or p38, and the specific JNK inhibitor SP600125 significantly blocked LPS induced KC expression and release."
23034047
reach
"CO has also been associated with the lipopolysaccharide induced JNK pathway [35] and has been demonstrated to interfere with NF-kappaB signal transduction [36,37]."
24512908
reach
"The toxin GalN converted LPS induced JNK signaling from a transient to prolonged activation."
16571730
reach
"Mechanistic studies demonstrated that FAD attenuated the LPS induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules."
29368095
reach
"Investigation of the mechanism by which GSK-3beta positively regulates LPS induced TNF-alpha demonstrated that loss of GSK-3beta activity abrogated LPS induced activation of JNK, leading to decreased c-Jun phosphorylation and AP-1 activation."
21194439
reach
"Whereas GalN and LPS treatment induced hepatic activation of NF-kappaB and JNK in wild-type and SphK2 -/- mice, these signaling pathways were reduced in SphK1 -/- mice."
33566377
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"XREF_FIG, pre-treatment OT (0.1, 1, 10muM) significantly suppressed LPS induced phosphorylation levels of ERK1/2 and p38 MAPK, while activation of JNK MAPK induced by LPS was not affected by OT."
27075756
reach
"Narciclasine inhibits LPS induced neuroinflammation by modulating the Akt/IKK/NF-kappaB and JNK signaling pathways."
33773188
reach
"Moreover, fasudil pretreatment obviously inhibited the activation of JNK and p38 MAPKs induced by LPS, whereas that of ERK1/2 was not affected by fasudil."
24406296
reach
"Our results showed that free GOT inhibited the activation of JNK induced by LPS after 24 and 48 hours, the level of phospho-JNK being compared with control cells."
29317816
reach
"Nuclear factor-kappaB (NF-kappaB), p38 mitogen activated protein kinase (MAPK), and c-Jun N-terminal kinase, which are all activated by LPS, were significantly inhibited by chrysin."
28671640
reach
"As shown in XREF_SUPPLEMENTARY, LPS activated ERK1/2 and JNK in a time dependent manner, as evidenced by the increases in phosphorylated ERK1/2 and JNK, but not p-38."
26288180
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"Furthermore, we demonstrate that dexamethasone, which inhibits the production of cytokines, including TNF-alpha, significantly inhibits LPS induction of JNK and SAPK activity but not that of p38, ERK1 and ERK2, or MEK3, MEK4, or MEK6."
9343388
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"Ex vivo studies provided evidence that human AR expression and activity augmented LPS induced JNK activation and IL-6 expression in lung cells and enhanced neutrophil shape changes induced by fMLP."
20007578
reach
"The results in Fig. 4A demonstrate that LPS, IL-1 and poly (I : C) activated the NF-kappaB, p38 and SAPK and JNK pathways to virtually the same extent (lanes 1-4)."
12062447
reach
"In glial cultures, LPS induced strong activation of ERK1/2, JNK and p38 in a time dependent manner, with maximum activation of p38 and JNK detected at 60 min, and ERK1/2 detected at 30 min (XREF_FIG a)."
23034047
reach
"LPS treatment activated the c-Jun N-terminal kinase (JNK) signaling pathway but inhibited the Wnt and beta-catenin pathway."
25337654
reach
"These findings suggested that overexpression of miR-30b promoted LPS induced JNK and NF-kappaB signaling pathways activation in HK-2 cells and suppression of miR-30b had opposite effects.To confirm th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29635893
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"LPS failed to activate JNK in IRAK-M -/- and wild-type osteoclasts."
15809356
reach
"LPS induced cleavage (activation) of caspase-3, an indicator of apoptotic change, and increased protein expression of proapoptotic molecules, Bax and Bim, and activation of c-Jun NH 2 -terminal kinase (JNK and SAPK) in the liver and spleen were attenuated by both simvastatin and FTI-277."
20034462
reach
"We found that S. abortus LPS leads to the upregulation of overall JNK activity in the brain."
26183892
reach
"All doses of galloyl-HHDP-glucose inhibited LPS induced JNK and NF-kappaB activation."
31481965
reach
"ROS from XO induces LPS induced JNK activation via inactivation of MAPK phosphatase- (MKP-) 1 [XREF_BIBR] and XO regulates cyclooxygenase-2, one of the master regulators of inflammation [XREF_BIBR]."
28070145
reach
"TLR4 signaling stimulated by LPS or L1CM results in the activation of NF-kappaB and MAPK family including ERK, JNK, and p38 MAPK, which drive the upregulation of pro inflammatory genes."
30863401
reach
"LPS does not effectively induce cytokines AP-1 and JNK in epithelial cells, which could be explained in part by lack of CD14 on epithelial cells."
9763607
reach
"Alcohol has been shown to impair LPS stimulated JNK activation by multiple mechanisms including the modification of lipid rafts and impairment of TLR4 downstream signaling."
21602669
reach
"Although CpG DNA at the higher concentration slightly enhanced LPS mediated phosphorylation of ERK, it did not alter the LPS mediated activation of c-Jun N-terminal kinase and p38."
11675371
reach
"It has been shown that activation of JNK by LPS or IL-1 results in modification and nuclear export of RXRalpha, and this may contribute to suppression of RXRalpha dependent hepatic genes [XREF_BIBR, XREF_BIBR]."
28537216
reach
"The role of JNK in induction of apoptosis in HMEC treated with LPS and CHX in HMEC."
19454725
reach
"The clear discrepancy of signal transduction pathway between angelan and LPS is that angelan does not activate SAPK and JNK, whereas LPS potently induces SAPK and JNK."
11460313
reach
"LPS induces activation of all three major classes of MAPKs : p38, JNK, and ERK."
18803301
reach
"Pretreatment with miR-146a-5p mimic or TRAF6 siRNA alleviating LPS induced JNK activation was also reported recently [XREF_BIBR]."
27399683
reach
"Rather, MLK4 appears to be able to inhibit lipopolysaccharide (LPS)-induced activation of the JNK or ERK pathways, but does not have effect on LPS induced p38 or NF-kappaB activation."
21602844
reach
"RT-qPCR was used to evaluate the effect of XBJ on the mRNA expression of TIPE2, p38 MAPK, JNK and NF-kappaB in the livers of rats treated with LPS + D-Gal and their control group in comparison with XBJ (5, 10 and 15 mg/kg BW) pre-treated groups."
27666960
reach
"CPT-2-Me-cAMP also prevented LPS induced activation of JNK and inhibition of AKT Taken together, these results suggest that LPS can induce hepatocyte apoptosis directly in vitro in a JNK dependent manner and activation of cAMP-GEF protects against the LPS induced apoptosis most likely by reversing the effect of LPS on JNK and AKT Introduction."
21743791
reach
"To demonstrate whether LPS promoted NF-kappaB and JNK signaling pathways by regulation of miR-127, the expression of miR-127 in H9c2 cells was knocked down by transfection with miR-127 inhibitor, and the efficiency of transfection was confirmed by qRT-PCR (P < 0.01, XREF_FIG)."
29451405
reach
"Overall, our results suggest for the first time that intracellular nef inhibited LPS activated JNK, which may cause inhibition of IL-12p40 expression in human monocytic cells by selectively inhibiting NFkappaB activity."
19019824
reach
"LPS added directly to endothelial cultures induced significant activation of JNK and ERK1/2."
23034047
reach
"As evidence of a broader role for the LTB4 and Ltb4r1 system in inflammatory responses, the Ltb4r1 inhibitor blocked LPS induced Jnk activation in IP-Macs from WT mice but was without effect on Ltb4r1 KO IP-Macs (XREF_FIG)."
25706874
reach
"We observed that LPS activated the p42/44 MAPK and JNK and SAPK in a time dependent manner, but there was no increase in the LPS induced phosphorylation of p38-MAPK in hNPECs."
20138035
reach
"The present study suggests that in BEAS-2B cells and U937 cells, LPS probably activates ERK1/2 pathway and JNK pathway, which in turn initiate AP-1 activity, and leading to MMP-9 expression."
30468094
reach
"Our data also indicate that SAHA reversed LPS triggered p38 and JNK pathway activation (XREF_FIG)."
25479907
reach
"Thus, TNF-alpha, UV irradiation, and lipopolysaccharide have all been shown to activate the JNK pathway."
9008162
reach
"Our results indicate that LPS activates JNK and PI3K pathways in macrophages to produce and release TNF-alpha protein, which down-regulates Pdcd4 in an autocrine manner."
20607724
reach
"Besides, the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and c-Jun N-terminal kinase (JNK) induced by LPS was also suppressed."
31564050
reach
"The inhibitory effect of p38 (mapk) appears more complex and may be due to the ability of p38 (mapk) to inhibit LPS induced JNK activation."
11171562
reach
"In S2 cells the JNK pathway is also activated in a dTAK1 dependent manner upon treatment by commercial preparation of LPS (XREF_FIG) XREF_BIBR, XREF_BIBR, XREF_BIBR."
19888449
eidos
"In this model , LPS stimulates alveolar macrophages via the TLR4 / CD14 / MD2 complex and the MyD88-dependent response , and activates nuclear factor kappa B ( NF-kappaB ) and c-Jun N-terminal kinase ( JNK ) that regulate the secretion of inflammatory mediators such as cytokines ( e.g ., IL-8 , TNF-alpha , IL-1beta , and IL-6 ) ( 3 ) ."
31481965
reach
"Recently, other studies have suggested that systemic administration of LPS activates oxidative stress and JNK which initiates downstream neuroinflammatory cascades."
31827700
reach
"One function of the protein is to interact with IL1RI, TLR2 and TLR4 after lipopolysaccharide (LPS) activation, thereby modulating the NF-kappaB and JNK signaling pathways and consequently inflammatory responses to infection XREF_BIBR."
27484700
reach
"Indeed, SREC-I expression was permissive for LPS induced JNK, p38 and ERK pathways in TLR4 expressing HEK 293 cells even when CD14 activity was deterred by CD14 neutralizing ab (CD14 inhibitor) (Fig XREF_FIG, XREF_FIG and XREF_FIG)."
25836976
reach
"Treatment with SP600125, a known JNK inhibitor, prevented the LPS induced hyper-activation of JNK and alleviated depressive like behaviors."
31901732
reach
"We have previously shown that the administration of S. abortus LPS activates TLR4 and JNK signalling in an experimental model of PTL."
26183892
reach
"Furthermore, LPS activation of cells of monocytic lineage rapidly activates the JNK pathway [XREF_BIBR]."
22461999
reach
"SRT2379 inhibited LPS-stimulated JNK and IκB kinase (IKK) inflammatory pathways in macrophages (49)."
34368195
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"In DCs co-treated with cisplatin and LPS, rapid and prolonged p38 phosphorylation and slightly activated JNK phosphorylation was observed compared to DCs treated with LPS alone."
27172902
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"In our present study, similar results were obtained, with OOA significantly inhibiting the LPS activation of ERK and JNK pathway, which suggests that OOA is at least partly responsible for the anti-inflammatory effects previously observed."
30190667
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"TRAF1 meditates lipopolysaccharide induced acute lung injury by up regulating JNK activation."
30760405
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"High dose LPS stimulation activated ERK, SAPK, and p38 kinases in both C3H and HeN and C3H and HeJ Mphi."
9921718
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"In microglia LPS activation of JNK increased NO and decreased apoE, the two inflammatory responses that we studied."
18803301
reach
"Importantly, IL-1- and LPS mediated JNK and ERK activation were substantially attenuated in Pellino 2 knock-down cells, implicating MAPK activation in TLR and IL-1R-induced mRNA stabilization."
22669975
reach
"Therefore, the septic shock patients infected with bacteria, especially G-bacteria, may activate the Notch signaling pathway via JNK dependent manner induced by LPS."
26063974
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"In this assay system, ghrelin prevented LPS-induced BV-2 p38 MAPK and JNK activation and attenuated proNGF and ROS production [260]."
28154473
reach
"One plausible interpretation of these data is that LPS induced activation of JNK leading to phosphorylation and likely further modification of RXRalpha, triggering its transport from nucleus to cytoplasm, where it may be targeted for degradation."
15312234
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"RR-ARFs inhibit the LPS and IFN-gamma-induced activation of JNK."
25167935
reach
"Febuxostat suppresses LPS induced activation of JNK."
24086554
reach
"Therefore, we examined whether TP inhibits LPS induced JNK and p38 activation."
24462677
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"Our results showed that BHD, mBHD-1, and mBHD-2 significantly reduced p38 and JNK activated by LPS but did not affect ERK1/2 phosphorylation."
32419816
reach
"Culture medium of L. rhamnosus GR-1 inhibits LPS induced JNK activation in macrophages or monocytic THP-1 cells."
30087667
reach
"Statistical analysis of the fold change of the relative density suggested that EGFR inhibition does not affect LPS activation of p38, ERK1/2, and JNK in RAW 264.7 macrophages (XREF_SUPPLEMENTARY)."
24391216
reach
"Crocin inhibits the activation of JNK induced by LPS."
26648423
reach
"The cylindromatosis tumor suppressor CYLD has been shown to inhibit both JNK and NF-kappaB signaling mediated by TNF, LPS, CD40, and IL-1 by cleaving K63 linked ubiquitin chains on TRAF2, TRAF6, and IKK-gamma."
21115689
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"[41,42] LPS activated JNK and p38 have been shown to regulate the production of TNF-alpha, IL-1b, and IL-6 in murine macrophages [26,43]."
24157331
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"The ERKs are activated by mitogens and growth factors, whereas the JNKs and SAPKs and p38/RK are activated by bacterial lipopolysaccharide (LPS), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12791252