IndraLab

Statements

TP53 binds MDM2 and NH. 9 / 9
| 9
sparser
"As mentioned above, MDM2 bound to NH 2 -terminal transactivation domain of p53 to destabilize and also inactivate p53."
21188172
sparser
"MDM2 directly binds to the NH 2 -terminal transactivation domain of p53 to inhibit its transcriptional activity and shuttles p53 out from the nucleus."
24503238
sparser
"MDM2 binds to the NH 2 -terminal transactivation domain of p53 and catalyzes the addition of ubiquitin to a cluster of six COOH-terminal Lys residues (Lys-370, Lys-372, Lys-373, Lys-381, Lys-382 and Lys-386) in p53 [ xref , xref ]."
24212651
sparser
"The NH 2 terminus of MDM2 protein binds to p53 and represses p53-mediated transcriptional activity [ xref ], whereas its COOH terminus contains a RING finger domain that is an E3 ubiquitin ligase, thus promoting p53 ubiquitination and proteasomal degradation [ xref ]."
27004407
sparser
"As mentioned above, MDM2 binds to the NH 2 -terminal region of p53 and inhibits its transcriptional as well as pro-apoptotic function."
24212651
sparser
"MDM2, which is a RING-finger type E3 ubiquitin protein ligase, bound to NH 2 -terminal transactivation domain of p53, ubiquitylated COOH-terminal 6 Lys residues (Lys-370, Lys-372, Lys-373, Lys-381, Lys-382, and Lys-386), and thereby targeting p53 for proteasome-dependent degradation [ xref ]."
21188172
sparser
"As mentioned above, MDM2 binds to NH 2 -terminal transactivation domain of p53 and strongly blocks its transcriptional as well as pro-apoptotic ability [ xref ]."
24078903
sparser
"It has been shown that p53 interacts with the NH 2 -terminal 58 aa of hMDM2, since removal of this segment abolishes this interaction ( xref )."
10562283
sparser
"It has been shown that MDM2 tightly binds to NH 2 -terminal transactivation domain of p53 and inhibits its transcriptional as well as pro-apoptotic function [1] ."
21093410