IndraLab

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Phosphorylated AKT increases the amount of HIF1A. 8 / 8
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"Previous studies [XREF_BIBR] have confirmed that hypoxia can stimulate the PI3K and AKT pathway by phosphorylating AKT, which induces the transcription of HIF-1alpha and stabilizes HIF-1alpha protein, which subsequently increases the expression of EPO and VEGF to promote erythropoiesis and angiogenesis."

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"Significantly, ruscogenin decreased the levels of MMP-2, MMP-9, uPA, VEGF and HIF-1alpha, down-regulated the phosphorylation of Akt, mTOR."

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"Specific inhibition of phosphorylated Akt reduces HIF-1alpha expression and in turn reduces HIF-1alpha-induced survivin expression, improving therapeutic responses to cisplatin."

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"At last, we found that NETs increased the phosphorylation of PI3K and Akt (XREF_FIG), leading to the activation of PI3K and Akt signaling pathway, therefore increased the expression of HIF-1alpha, and activated the following physiological processes."

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"The hypoxic culture stimulated the phosphorylation of ERK1/2 and Akt induced HIF-1alpha expression."

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"The expression of HIF-1alpha might be activated by AKT phosphorylation, as we previously reported XREF_BIBR, whereas the over-expression of CypA might stimulate the proliferation of human pancreatic cancer cells by activating the ERK1/2 and p38 pathways XREF_BIBR - XREF_BIBR."

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"pVHL and p-AKT associatedin vitro, and knockdown of pVHL rescued HIF1alpha expression and the cells from apoptosis 36."
| PMC

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"pVHL and p-AKT associated in vitro, and knockdown of pVHL rescued HIF1alpha expression and the cells from apoptosis36."
| PMC