IndraLab

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Phosphorylated TP53 increases the amount of CDKN1A. 11 / 11
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"XREF_BIBR Phosphorylated p53 up-regulates p21 Waf1 and Cip1 transcription via a p53 responsive element and activation of p53 leads to either cell cycle arrest and DNA repair or apoptosis."

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"Phosphorylation of p53 stabilizes the protein and leads to increased transcription and expression of p21."

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"XREF_BIBR During cell cycle stages when CDC2 and cyclin B or CDK2 and cyclin A are active, p53 is phosphorylated and upregulates p21 Waf1 and Cip1 transcription via a p53 responsive element."

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"As shown in XREF_FIG A, phosphorylation of p53 enhances the expression of p21 protein in wild-type p53 B16BL6 and B16F10 spheroids."

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"AF metabolites, presumably though the CYP and SULT driven bioactivation pathway, have been shown to be DNA damaging agents, inducing DNA protein crosslinks, cytokeratin-RNA crosslinks, phosphorylation of p53, increased expression of p21, gamma-Histone 2AX (gamma-H2AX), reactive oxygen species mediated apoptosis, and S-phase arrest in sensitive populations of cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."

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"Phosphorylation of Cdc25 family contributes to G2/M arrest, while phosphorylation of p53 enhances the transcription of p21 waf1 and cip1 and result in G1 arrest and/or G2/M arrest (Matsuoka et al., 19[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Transduction of mesothelioma cells with adenoviruses bearing the p53 gene (Ad-p53) induced phosphorylation of p53, upregulated Mdm2 and p21 expression levels and decreased phosphorylation of pRb."

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"Upregulation and phosphorylation of TP53 are in turn sufficient to activate CDKN1A gene expression."

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"This finding suggests that an earlier G1 arrest of hydroxyurea treated HCT116 DeltaPR130 cells is due to an augmented phosphorylation of p53, which activates p21 expression (Figs."

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"Increased phosphorylation of p53 may up-regulate expression of p21 leading to cell cycle arrest or the expression of cell surface receptors like Fas as well as mitochondrial pro apoptotic proteins like Bax, Bak, PUMA and NOXA XREF_BIBR, XREF_BIBR."

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"P53 is phosphorylated and upregulates p21 Waf1 and Cip1 transcription via a p53 responsive element during cell-cycle stages."