IndraLab

Statements

Mutated TP53 increases the amount of CDKN1A. 18 / 18
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"In our models, p21 expression was induced by these agents in both p53 wild-type (THJ-11T, THJ-29T) and p53 mutant (THJ-16T, THJ-21T) cells."
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"Thus, cells expressing mutant p53 that can not induce transcription of p21 and Bax fail to undergo cell cycle arrest or apoptosis in response to DNA damage, leading to unregulated cell division, additional mutagenesis, and, potentially, tumor formation 20."
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"Unlike wild-type p53, mutant p53 protein fails to activate p21 gene expression4, and the loss of p53 func- tion confers decreased apoptotic potentiaPB."
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"It has been established that p53 mutant such as R175H failed to induce p21 expression and cell-cycle arrest."
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"One explanation of this phenomenon is the possibility that p53 mutation led to low p21 expression and changed susceptibility to cancer treatment [XREF_BIBR, XREF_BIBR]."
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"However, our qPCR analysis showed that expression of CDKN1A, PMAIP1, BBC3, and 14-3-3sigma was increased by APR-246 in the two mutant p53 expressing cell lines."
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"Most of these poorly BCL-xL-sequestered p53 mutants, however, did not activate p21 or puma transcription, despite exhibiting near wild-type-like DNA binding in vitro (XREF_FIG)."
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"This mutant p53 lacks a DNA binding motif and is unable to induce p21 expression [20,21]."
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"Furthermore, constitutively activated mutant p53 378D promoted higher p21 expression than the unphosphorylatable p53 378A mutant (XREF_FIG)."
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"Immunoblotting and flow cytometry showed that the TP53 mutation p.(P80S) was able to induce comparable levels of p21 expression as the wild-type p53."
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"Compared to the controls, gene analysis demonstrated that mutant p53 cell lines decreased the expression of p21 and p15 tumor suppressors upon TGF-β stimulation; however, the gene expression of MMPs and Slug was increased compared to the control, which was correlated with enhanced cellular migration [36]."
| PMC
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"Thus, p21 transcription is upregulated by wild type but not mutant p53 in response to DNA damage [18], and p27 was initially identified as the factor responsible for inhibiting proliferation in contac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, transfection of the p53 mutant 248Trp failed to activate WAF1 and Cip1 expression."
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"The residual repressive activity was the result of the ability of p53 to induce apoptosis as a p53 mutant that is able to induce p21 expression but unable to induce apoptosis (p53 R175P) completely lost repressive activity in the absence of p21 (XREF_FIG)."
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"Since mutant p53 depletion in Panc-1 cells further augmented SAHA induced decrease in cell viability and also increase in the amount of cell cycle related p21 WAF1, it is possible that, unlike MiaPaCa-2 cells, mutant p53 knockdown in Panc-1 cells might contribute largely to the potentiation of SAHA mediated cell cycle arrest and cell cycle retardation rather than cell death."
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"Mutant p53 did not up-regulate the expression of its direct downstream targets PUMA and p21, due to the inhibition of PUMA transcription."
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"Surprisingly, mutant p53 transcriptionally activates the expression of p21, which localizes to the cytoplasm of HGSC cells where it plays a non canonical, pro proliferative role."
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"Treatment with poly (I : C) had no impact on WT or p53 mutant mediated expression of the p53 target genes p21 and PUMA (BBC3) (XREF_SUPPLEMENTARY)."
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