IndraLab
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"In parental and EGFR -/- A549 cells bearing EGFR WT plasmid, EGF promoted the expression of nuclear EGFR target genes with a peak at 2 h and declined to baseline at 4-8 h, whereas PGE 2 mimicked the EGF effect on target genes with a peak at 4 h and declined toward the baseline at 8-12 h."
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"Therefore, WDR81 patient cells display reduced EGFR levels, leading to a reduced activation of the MAPK signaling pathway upon EGF stimulation.The levels of EGFR are known to be tightly regulated, through complex feedback loops and the balance between recycling and degradation of the internalized receptor ."
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"This way, targeting of nanocarriers to integrin alphavbeta3 in tumor vasculature by cyclic RGD (arginine-glycine-aspartic acid) peptide [XREF_BIBR], to prostate specific membrane antigen on prostate cancer cells by specific primary antibody [XREF_BIBR], to epidermal growth factor receptor (EGFR) of EGFR overexpressing tumors by epidermal growth factor (EGF) [XREF_BIBR, XREF_BIBR], to liver by hyaluronic acid derivatives [XREF_BIBR], and to the brain by wheat germ agglutinin [XREF_BIBR] has been demonstrated."
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"This study demonstrated that the secretory overexpression of pEGF in C. butyricum could upregulate the expression level of EGFR, consequently improving the intestinal protective functions of C. butyricum partly following STAT3 signal activation in IPECs and making it a positive loop."
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"As shown in Figure XREF_FIG, XREF_SUPPLEMENTARY, both CrkY251 and AblY245 were immediately phosphorylated after 1min of EGF stimulation in multiple GBM lines that include U138, HS168, T98G and U118MG, suggesting CrkY251 phosphorylation is a routine post-receptor event following EGF stimulation in EGFR expressing GBM."
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"Apart from the proangiogenic effects of BMDCs recruited by tumors as described above, bone marrow derived tumor associated macrophages (TAMs) have been shown to enhance breast cancer invasion in a paracrine loop in which EGF produced by TAMs stimulates the migration and invasion of neighboring EGF receptor expressing tumor cells."
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"To determine whether dynein also regulates the nuclear trafficking of EGFR, we treated cells with its inhibitors, vanadate and EHNA, and found that disruption of dynein ATPase activity decreased EGF induced nuclear localization of EGFR and protein level of EGFR in the nucleus (XREF_SUPPLEMENTARY)."
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"However, it has also been demonstrated that EGF stimulates cell proliferation in a dose dependent manner (1, 3, and 30 ng/ml; i.e. approximately 0.16, 0.5, and 5 nM) in accordance with EGF stimulated phosphorylation amounts of EGFR in A431 cells, which are more sensitive to a EGFR tyrosine kinase inhibitor, Gefitinib (Iressa) [XREF_BIBR]."
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"Similarly, EGF treatment significantly increased the blastocyst formation rate, the total number of cells per blastocyst, the cell ratio of the inner cell mass and the trophectoderm, and EGFR protein expression in cloned mouse embryos, and these effects were enhanced when EGF and TGF-alpha were combined [XREF_BIBR]."