IndraLab

Statements


EGF increases the amount of EGFR. 139 / 155
2 | 134 2 1

reach
"EGF induced proliferation was observed in all EGFR expressing PC cells except PC3, indicating that EGFR expression does not unequivocally trigger proliferation following EGF stimulation."

reach
"EGF stimulation increased the expression of EGFR, iNOS, EP1, EP2, and EP4 in astrocytes."

reach
"Combination of EGF and PGE2 promotes the transcription of nuclear EGFR target genes up to 8 hours."

reach
"Repetitive injections of exogenous epidermal growth factor during the interval of rapid growth in rats increased the lung volume, weight and epidermal growth factor receptor expression as compared with untreated animals [XREF_BIBR]."

reach
"In conclusion, in ovo application of EGF increased EGFR expression but had no effect on posthatch growth performance, DM retention, and intestinal development."

reach
"This led to a delay in EGF-induced EGFR degradation in Huh7.5 cells and could, at least partly, restore the declined EGFR levels observed in GABARAP SKO cells in response to EGF stimulation shown in Figure 2A, as the total EGFR levels were only significantly reduced after 60 min."

reach
"In addition, the physical interaction between MUC15 and EGFR effectively prevented the EGF induced dimerization of EGFR and the cell surface expression of EGFR and enhanced the EGF induced endocytosis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"[XREF_BIBR] Here, we demonstrated that the amount of EGFR expression in response to EGF was reduced in the absence of Le y modification."

reach
"In parental and EGFR -/- A549 cells bearing EGFR WT plasmid, EGF promoted the expression of nuclear EGFR target genes with a peak at 2 h and declined to baseline at 4-8 h, whereas PGE 2 mimicked the EGF effect on target genes with a peak at 4 h and declined toward the baseline at 8-12 h."

reach
"Importantly, ephrinA1 seemed to reduce EGF induced cell viability in U373 cells expressing low EGFR levels."

isi
"There was no effect of EGF (P > 0.05) on EGFR expression on day 17 to 20; however, on day 21, EGF increased (P < 0.05) EGFR expression in EGF birds relative to control birds."

reach
"Therefore, WDR81 patient cells display reduced EGFR levels, leading to a reduced activation of the MAPK signaling pathway upon EGF stimulation.The levels of EGFR are known to be tightly regulated, through complex feedback loops and the balance between recycling and degradation of the internalized receptor ."

reach
"EGF Stimulation Induces Endogenous TACC3 Expression in EGFR expressing Cells."

reach
"Conversely, silencing of Hes1 inhibited EGF induced cell invasion and downregulation of MMP-7 and EGFR expression contributed to the reduced invasive ability of shHes1-CSC."

reach
"EGF can increase EGFR gene transcription in liver cells two-fold, at the same time increasing the level and stability of EGFR mRNA (37)."

reach
"EGF treatment reduced the relative kidney weight and common bile duct dilation and downregulated renal expression of clusterin and EGF receptor."

reach
"After translocating to the nucleus, the complex formed by DHT and androgen receptors (ARs) may directly bind to the androgen response element (ARE) in the promoter region of the EGF gene, which simultaneously increases the expression of the EGFR gene (53–55)."

reach
"The blockage of p38 signaling using BIRB769, a pharmacologic p38 inhibitor, restored EGFR expression downregulated by anisomycin but not by EGF stimulation (XREF_FIG)."

reach
"The expression of EGFR protein and mRNA in RPE cells was also increased by EGF."

reach
"In the Rab25 expressing cells, EGF treatment caused the cell-surface EGFR level to be lower than that in control cells between 15 and 40 min but higher after 60 min, suggesting a possible role of Rab25 in regulating EGFR trafficking."

reach
"EGF stimulation increased EGFR, Akt, Src, and IGF-1R phosphorylation in A549 and H460 cells but not in H522, a low EGFR expressing cell line [XREF_BIBR]."

reach
"These results suggest that the oncogenic function of mir-192 might be partially compensated by reduced EGF signaling activity due to reduced EGFR protein levels."

reach
"This way, targeting of nanocarriers to integrin alphavbeta3 in tumor vasculature by cyclic RGD (arginine-glycine-aspartic acid) peptide [XREF_BIBR], to prostate specific membrane antigen on prostate cancer cells by specific primary antibody [XREF_BIBR], to epidermal growth factor receptor (EGFR) of EGFR overexpressing tumors by epidermal growth factor (EGF) [XREF_BIBR, XREF_BIBR], to liver by hyaluronic acid derivatives [XREF_BIBR], and to the brain by wheat germ agglutinin [XREF_BIBR] has been demonstrated."

reach
"After observing that tethered EGF modulates EGFR protein levels and results in sustained activation under conditions that induce osteogenic differentiation, we sought to determine whether tEGF influenced MSC differentiation."

reach
"Additionally, epidermal growth factor (EGFR) aptamer was conjugated on the surface of hybrid NPs to target the EGFR overexpressed in OSA."

reach
"Our study reported, for the first time, a relationship between the effects of EGF on cell proliferation and levels of EGFR expression in one cell line expressing different levels of EGFR caused by different concentrations of EGF treatment."

reach
"EGF also stimulated EGFR messenger RNA levels, shown by Northern blot analysis."

reach
"The data presented in XREF_FIG (panel A) demonstrate that EGF increased the amount of EGFR in phosphotyrosine immunoprecipitates, and that this effect is unchanged in the presence of Jak2 inhibitor, but is completely abolished after pretreatment with AG1478."

reach
"However, in contrast to Y845, EGF stimulation increased its average phosphorylation independent of EGFR expression."

reach
"EGF increased the phosphorylation levels of EGFR, AKT and ERK, and increased the expression of MMP-2."

reach
"GABARAPL1 and GABARAPL2 SKO cells were analyzed likewise with regards to EGFR protein levels in response to EGF treatment to analyze the role of the two other GABARAP subfamily members."

reach
"However, EGF significantly enhanced the expression of ileal EGF receptor mRNA to an equal extent after both sham and SBR (approximately threefold)."

reach
"EGF Activates EGFR Expression in MG63 Cells and Promotes Cell Migration by Increasing Actin Stress Fiber Formation."

reach
"Interestingly, EGF stimulation of MB increased cellular levels of pEGF-R (XREF_FIG) by 2.8 fold (XREF_FIG), indicative of a ligand dependent EGF-R response regardless of basal EGF-R signaling."

reach
"EGF and TGFa do not regulate EGF-R mRNA turnover in A431 cells h EGF and TGFa did not significantly upregulate EGF-R expression in A431 cells, we sought to determine if there were differences in the b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"In MDA MB-468 cells, EGF increased levels of pEGFR and pErbB3 whereas EGF and HGF together increased phosphorylated MET, EGFR and ErbB3."

reach
"showed that under in vivo conditions, EGCG could reduce the autophosphorylation level of EGF-R induced by EGF."

reach
"We also found that EGF stimulates invasion in established GBM lines, or low EGFR expressing PDX cells."

reach
"As PBK and TOPK could be induced by EGF [5] and expression of EGF receptor increased in human cholangiocarcinoma [19], we explored whether EGF could induce PBK and TOPK expression in the cholangiocarc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"It is known, the upregulation of EGFR expression by EGF is considered a mechanism that promotes the development and progression of tumors [XREF_BIBR]."

reach
"Both EGF and linoleic acid strongly stimulated the expression of EGF receptor mRNA in C2BBe1 cells at 48 h compared with the control and combined groups."

reach
"Injections of epidermal growth factor (EGF) enhanced the expression of EGFR mRNA but not EGF mRNA through day 5 postnatally in the follicle."

reach
"The results showed that EGF treatment trigger EGFR and Erk signaling by increased the levels of p-EGFR and p-Erk1/2."

reach
"EGF induced expression of the STAT3 target gene HIF1alpha was abolished by cetuximab in HNSCC cells expressing wild-type EGFR under hypoxic conditions, but not in EGFRvIII expressing HNSCC cells [XREF_BIBR, XREF_BIBR]."

reach
"EGF (25 ng/mL, 24 hours) augmented the expression and phosphorylation of the EGFR."

sparser
"The results showed that EGF-induced expressions of pEGFR, TGF-β1, pSmad3, collagen I and collagen III were significantly decreased in LF cells after treatment with erlotinib (100 nmol/L) (Fig. xref )."

reach
"After translocating to the nucleus, the complex formed by DHT and androgen receptors (ARs) may directly bind to the androgen response element (ARE) in the promoter region of the EGF gene, which simultaneously increases the expression of the EGFR gene (53) (54) (55) ."

reach
"EGF induced higher EGFR expression in corneal tissues by immunofluorescent staining and Western blot analysis."

reach
"In accordance with our phenotypic observations, from a mechanistic point of view, dynasore strongly suppressed the EGF stimulated activation of EGFR, AKT, and MEK, as well as reduced the steady state [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"As shown in XREF_FIG, EGF increased the level of phosphorylated EGFR significantly in ESCC cells whether they had high or low EGFR expression."

reach
"Kirk), Carmichael J, Stratford I) and Harris AL, Selective toxicity of TGF-a-PE40 to EGFR positive cell lines : Selec- tive protection of low EGFR expressing cell lines by EGF."

reach
"Otherwise, EGFR expression was induced by either EGF (P < 0.05) or E2 (P < 0.01)."

reach
"Although EGF increased the EGF receptor levels in the early and late liver endosomal fractions of waved-2 mice, its trafficking was delayed compared to wild-type mice."

reach
"Taken together, these results demonstrate that in KB cells EGF and TGFa upregulate EGF-R expression at both transcriptional and post-transcriptional levels."

reach
"Upstream of the EGF cascade, c-Jun increases EGF receptor expression."

reach
"This study demonstrated that the secretory overexpression of pEGF in C. butyricum could upregulate the expression level of EGFR, consequently improving the intestinal protective functions of C. butyricum partly following STAT3 signal activation in IPECs and making it a positive loop."

reach
"1) CFBP interacts with CD2AP family proteins and functions as a key component in downregulation of EGF receptor protein level following EGF stimulation."

reach
"Of note, recent studies demonstrated that macrophages isolated from human breast tumors could release epithelial growth factor (EGF) [XREF_BIBR], while MUC1 has been reported to enhance EGFR expression and involving in neoplasia and cell adhesion [XREF_BIBR]."

reach
"As shown in Figure XREF_FIG, XREF_SUPPLEMENTARY, both CrkY251 and AblY245 were immediately phosphorylated after 1min of EGF stimulation in multiple GBM lines that include U138, HS168, T98G and U118MG, suggesting CrkY251 phosphorylation is a routine post-receptor event following EGF stimulation in EGFR expressing GBM."

reach
"We therefore conclude that all these cell lines show similar EGFR expression levels, which are comparable to the expression seen in HER-14 cells, thereby allowing a fair comparison between different c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Pretreatment with sulindac metabolites for 24 h blocked EGF induced phosphorylation of both EGFR and ERK1/2 and decreased total EGFR protein expression."

reach
"In the presence of exogenous uridine, A77 1726 was more effective at inhibiting the PDGF stimulated proliferation of PDGF receptor overexpressing C6 glioma than the EGF stimulated proliferation of EGF receptor overexpressing A431 cells."

reach
"Further- more, it was demonstrated that both EGF and TGFa can stimulate the expression of c-fos and c-myc in esophageal carcinoma cell lines, whereas EGF treatment can induce EGFR mRNA expression by ~[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"However, EGF treatment, but not PDGF or FGF, caused a marked down regulation of EGFR protein levels, even though at the transcriptional level the response of EGFR to the three different growth factors was consistently similar."

"Here, we show that cigarette smoke exposure not only results in aberrant phosphorylation of the receptor, similar to H2O2 exposure (Fig. 3), but we also show that the EGFR is not internalized in the same manner as it is under EGF exposure."

reach
"At 10 mpi, both TGEV and EGF increased the phosphorylation level of EGFR, but EGFR specific inhibitor AG1478 significantly impaired EGFR phosphorylation."

reach
"Overall, results showed that EGF conjugation to nanocarriers could effectively target the EGFR overexpressing lung cancers when administered by inhalation."

reach
"In this study, using breast cancer cell lines, we show that the HER receptor ligands, EGF and neuregulin (NRG-1β), as well as the phorbol ester, PMA, can increase the expression of EGFR isoform D, as well as isoform A."

reach
"At 10 mpi, both TGEV and EGF increased the phosphorylation level of EGFR, but EGFR specific inhibitor AG1478 significantly impaired EGFR phosphorylation (Figure 5A)."

reach
"Apart from the proangiogenic effects of BMDCs recruited by tumors as described above, bone marrow derived tumor associated macrophages (TAMs) have been shown to enhance breast cancer invasion in a paracrine loop in which EGF produced by TAMs stimulates the migration and invasion of neighboring EGF receptor expressing tumor cells."

reach
"In agreement with our previous studies, XREF_BIBR exogenous EGF restored functional EGFR protein levels in IECs of TPN treated mice (XREF_FIG A)."

reach
"As expected, both EGF and EC CM treatment mediated downregulation of total EGFR expression, which was rescued with the use of anti-EGF antibody (XREF_FIG)."

reach
"In order to confirm this speculation, EGF induced EGFR activation was examined in EGFR high expressed MDA-MB-468 cells."

reach
"Mechanistic studies with mitogen activated protein kinase and phosphatidylinositol 3-kinase pathway specific inhibitors revealed that biglycan and EGF distinctly modulate the expression of EGFR in chondrocytes."

reach
"EGFR mRNA level was enhanced fourfold by EGF while alpha-subunit mRNA was reduced by EGF."

reach
"XREF_BIBR - XREF_BIBR We have previously shown that epidermal growth factor stimulates EGFR expressing TNBC cells such as SUM149, MDA-MB-468, and BT-20 and induces upregulation of phosphorylation of ERK and/or Akt."

reach
"In addition, the combination of ERbeta5 and EGF increases the expression of ERbeta5, EGFR, and p-ERK1/2 in lung cancer cells."

reach
"In this study, we elucidate a novel regulatory mechanism of EGFR expression in human articular chondrocytes that is modulated by prolonged biglycan treatment and is in contrast to changes detected in the expression of EGFR following EGF stimulation."

reach
"On the other hand, EGF increased the EGF receptor levels up to two or three fold within 24 h after EGF injection."

reach
"EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques."

reach
"Interestingly, stupendous increase in the expression of FTS was evidenced after EGF treatment for 24 h.EGF induced the expression of EGFR in a time dependent manner."

reach
"EGF Stimulation Induces EGFR Expression in the Nucleus in Ovarian Cancer Cell Lines."

reach
"Enteral EGF supplementation prior to injury significantly decreased both the incidence and severity of NEC, as well as diminished EGFR expression."

reach
"We saw that the EGF treatment increased the expression of CAGE and pEGFR Y845 while decreasing the expression of HDAC3 (XREF_FIG)."

reach
"Labelling of the natural ligand, EGF, with 68 Ga 31 or 18 F 32 enabled specific imaging of EGFR expressing xenografts with tumour-to-blood ratios in the range of 2-5."

reach
"Furthermore, we demonstrate that Runx2 expression increases EGF induced phosphorylation of epidermal growth factor receptor (pEGFR) and relieves Mek and Erk mediated negative regulation of pEGFR and pAkt levels."

reach
"Ligand activation of EphA2 and EphA2 knockdown by small interfering RNA inhibit EGF induced cell motility of EGFR overexpressing human cancer cells, indicating a functional role of EphA2 in EGFR expressing cancer cells."

reach
"In the EGF stimulated condition, our results demonstrated that EGF (100ng/ml, 10min) evidently increased the expressions of p-EGFR, p-STAT3 and p-Akt in A431 cells compared with the control group (XREF_FIG B)."

reach
"Here, we show that EGF induces EGFR expressing cancer cells to undergo a transition from the epithelial to the spindle like mesenchymal morphology."

reach
"EGF stimulation of UW473 cells increased phospho protein expression of EGFR, ERK1/2, RSK1/2/3, WNK1, CREB, c-Jun, p38a, Akt (S473) and PRAS40 (XREF_FIG, XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

reach
"Having demonstrated that EGF activation of EGFR expressed by pancreatic cancer cells downregulates the cells’ HLA class I expression, we hypothesized that inhibition of EGFR by the tyrosine kinase inhibitor erlotinib would increase HLA class I expression."

reach
"K.L. Thompson, M.R. Rosner, Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor, J. Biol."

reach
"[29] Thompson, K.L. and Rosner, M.R. (1989) Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor."

reach
"* The overexpressed pEGF upregulated the expression level of EGFR and further magnified the gut protective function of recombinant strains which in turn partly depended on STAT3 signal pathway in IPECs."

reach
"This finding is contrary to that of a previous study in which EGF supplementation at 0.1 ng/ml significantly increased EGFR expression in preimplantation mouse embryos compared with the control and groups treated with higher concentrations of EGF (1, 10 and 100 ng/ml)."

reach
"These findings suggest an extra dose of EGF given above the physiological dose can stimulate the expression of intestinal EGFR, and the combination of EGF with EGFR can amplify the biological role of EGF, thereby reducing intestinal damage."

reach
"Specifically, EGF activation of EGFr expressed on glioma cells leads to enhanced secretion of VEGF by glioma cells."

reach
"Taken together, these results demonstrate that in KB cells EGF and TGF alpha upregulate EGF-R expression at both transcriptional and post-transcriptional levels."

reach
"To characterize the effects on signaling pathways in another TNBC model, we conducted immunoblotting on MDA-MB-231 cells, in which EGF treatment phosphorylated EGFR and induced EGFR expression."

reach
"EGF (Epidermal Growth Factor) is a known inducer of EMT and growth of A431 cells in the absence of oxygen led to increased expression of EGFR (EGF Receptor)."

reach
"On the other hand, a combined supplementation of EGF and HA induced the expression level of EGFR, this may suggest the potential role of HA in EGFR activation through specific receptors of HA namely, CD44 and HMMR [51, 62–65]."

reach
"Selective toxicity of TGF-alpha-PE40 to EGFR positive cell lines : selective protection of low EGFR expressing cell lines by EGF."

reach
"We also found that PTPRO suppression inhibits down-regulation of EGFR expression triggered by EGF stimulation."

reach
"In this study, an EGF conjugated anthrax toxin was used to target EGFR expressing human and canine TCC cell lines."

reach
"We found that EGF treatment was able to induce both ER-alpha36 and EGFR expression in HCC cells."

reach
"To determine whether dynein also regulates the nuclear trafficking of EGFR, we treated cells with its inhibitors, vanadate and EHNA, and found that disruption of dynein ATPase activity decreased EGF induced nuclear localization of EGFR and protein level of EGFR in the nucleus (XREF_SUPPLEMENTARY)."

reach
"However, it has also been demonstrated that EGF stimulates cell proliferation in a dose dependent manner (1, 3, and 30 ng/ml; i.e. approximately 0.16, 0.5, and 5 nM) in accordance with EGF stimulated phosphorylation amounts of EGFR in A431 cells, which are more sensitive to a EGFR tyrosine kinase inhibitor, Gefitinib (Iressa) [XREF_BIBR]."

reach
"EGF stimulation activated pEGFR expression as expected, and such activation was inhibited by GM 3."

sparser
"Moreover, the overexpression of PARK2 significantly mitigated the EGF-induced protein expression of p-EGFR, p-AKT, and p-mTOR."

reach
"EGF has been shown to induce EGFR-expressing cancer cells to convert from an epithelial to mesenchymal phenotype, termed epithelial-to-mesenchymal transition (EMT)."

reach
"It is known that the upregulation of EGFR expression by EGF is considered a mechanism that promotes the development and progression of lung tumors [XREF_BIBR, XREF_BIBR]."

reach
"70 Local secretion of EGF preferentially stimulates EGF receptor expressing breast cancer cells, inducing the pluripotency gene SOX-2 through activation of STAT3 enhancing their survival and proliferation."

reach
"However, EGF could enhance the mRNA expressions of c-myc, c-erbB2 and EGFR to various extents, but inhibit that of TGF beta 1 gene."

reach
"On the other hand, EGF significantly enhanced the transcription of EGFR."

reach
"EGFR mRNA levels were stimulated by EGF and keratinocyte growth factor treatment and inhibited by testosterone treatment in epithelial cells."

reach
"CMS2 also represents over-activation of epidermal growth factor (EGF)-related signaling pathways, with higher expression of the epidermal growth factor receptor (EGFR)[13]."

reach
"The level of nuclear EGFR and STAT3 complex was significantly enhanced by 30 min of EGF treatment."

reach
"Therefore, a 2-fold reduction of a surface EGFr expression by EGF induced intemalization may result in significant reduction in CT sensitivity."

reach
"EGF promoted the expression of EGFR protein and mRNA in RPE cells."

reach
"Through cell fractionation separating the nuclear and cytoplasmic fractions, we found that EGF treatment could induce expression of EGFR in the nucleus in all three ovarian cancer cell lines (XREF_FIG)."

reach
"Indeed, EGFR and c-Src are expressed and could be activated by EGF, suggesting that the EGFR and c-Src signaling is intact in breast cancer cell lines (Additional file 2 : Fig. 2B)."

"Confocal microscopy, as well as biochemical fractionation, indicated that the EGFR translocates to the mitochondria after EGF stimulation, where it colocalizes with CoxII. "

reach
"These findings imply a potential role of EGF- and gefitinib modulated EGFR expression in predicting gefitinib sensitivity."

reach
"The expression levels of EGF protein (Figures 6(a) and 6(b)) indicate that hADSCs promote the expression of EGFR in skin wounds."

reach
"EGF treatment caused an increase of the level of serpine-1 and pEGFR levels and then increased growth activity in HD6 overexpressing cells."

reach
"EGF and TGFcc increase expression of EGF-R protein in KB but not A431 cells."

reach
"This reduced intrinsic activity is likely to reflect the fact that EGF stimulates greater EGFR turnover and reduced steady-state EGFR expression than does TGFalpha (XREF_FIG, lower panel)."

reach
"We recently have observed that EGF increases the expression of EGF receptor mRNA and protein content in the remnant ileum after SBR."

reach
"The inhibition of EGF uptake may be due to lower cell surface levels of EGFR."

reach
"Luciferase assays with a panel of human breast cancer cell lines revealed that EGF potentiated FOXC1 promoter activity specifically in BLBC cells (XREF_SUPPLEMENTARY), consistent with the notion that EGFR is preferentially expressed in BLBC cells."

reach
"To investigate whether the transcription of nuclear EGFR target genes induced by the combination of EGF and PGE 2 could mediate and sustain NSCLC cell proliferation compared to single stimuli, the A549 EGFR-knockout cells described above were used."

reach
"Modulation of tissue cAMP and EGF receptor levels by EGF was also studied to reveal the mechanism of the growth inhibitory effects of EGF."

reach
"Similarly, EGF treatment significantly increased the blastocyst formation rate, the total number of cells per blastocyst, the cell ratio of the inner cell mass and the trophectoderm, and EGFR protein expression in cloned mouse embryos, and these effects were enhanced when EGF and TGF-alpha were combined [XREF_BIBR]."

reach
"Using two Golgi markers, syntaxin 6 and Vti1b, we found that fraction 9 isolated from density gradient ultracentrifugation was the Golgi enriched fraction (XREF_FIG) and EGF stimulation enhanced EGFR expression in this fraction (XREF_FIG)."

reach
"18 In the kidney, EGFR is expressed in PTEC, and activated by EGF and EGF like hormones."

reach
"Biotinylated epidermal growth factor (EGF) enabled specific targeting of the virus with high efficiency to EGF receptor expressing (SKOV-3) cells."

reach
"In addition, EGF treatment in GSC11 cells or Dox induced EGFRvIII expression in LN229 and EGFRvIII tet-on cells decreased the mRNA expression of LXRA and HIVEP2, whereas knockdown of YTHDF2 reversed the effects of EGF and EGFRvIII."

reach
"Because SPACE can penetrate skin and cells and EGF can target the EGFR overexpressed in cancer cells, SPACE-EGF is expected to carry siRNAs into B16 cells, which would then induce the apoptosis of B16 cells."

reach
"Here we show that intraventricular injection of EGF induces within minutes CREB and ERK phosphorylation in astrocyte like progenitor cells (type B cells) and EGF receptor expressing transit amplifying progenitor cells-both in the striatal and septal ventricular walls."